Article
Hematology
Margot Cornette, Tinne Monteyne, Pieter M. De Kesel, Katrien M. J. Devreese
Summary: The study found that a certain percentage of patients undiagnosed with traditional laboratory testing showed abnormal parameters through thrombin generation testing. However, a considerable proportion of previously diagnosed patients also exhibited abnormal parameters. No relevant lot-to-lot reagent variability was observed in the two thrombin generation testing platforms.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Dino Mehic, Georg Neubauer, Florian Janig, Alexandra Kaider, Cihan Ay, Ingrid Pabinger, Johanna Gebhart
Summary: This study aims to investigate the future bleeding risk and the need for hemostatic treatment in patients with mild-to-moderate bleeding disorders. The results show that almost all patients have a risk of recurrent bleeding and previous interventions and hemostatic challenges increase the risk of bleeding. Therefore, prophylactic hemostatic treatment is crucial for these patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Chemistry, Applied
Yuting Shi, Wenwen Yu, Xiaoqin Liang, Ju Cheng, Yufei Cao, Mingsheng Liu, Yu Fang, Zheng Yang, Hongbin Liu, Hua Wei, Guanghui Zhao
Summary: Preventing arterial hemorrhage is crucial, but current hemostatic materials are not effective in extreme conditions. Therefore, we developed an expansion sponge based on chitosan and plasma, which provides a simpler and more efficient method for treating high-pressure arterial bleeding wounds.
CARBOHYDRATE POLYMERS
(2023)
Article
Hematology
Pauline Vermeiren, Arne Vandevelde, Harlinde Peperstraete, Katrien M. J. Devreese
Summary: This study compared the effectiveness of global coagulation assays, including thrombin generation assay (TGA), with the anti-Xa assay for monitoring heparin therapy. The results showed that the TGA may not be sensitive enough for low concentrations of low molecular weight heparin (LMWH), but it could be a useful additional tool for monitoring heparin therapy in heparin-resistant patients.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Review
Critical Care Medicine
Jessica C. Cardenas
Summary: Thrombin plays a central role in coagulation, essential for normal hemostasis. The generation of thrombin in severely injured patients is closely related to the risks of bleeding and thrombotic complications, and understanding the determinants of its production is clinically important.
Article
Hematology
Julia R. Coleman, Hiroshi Deguchi, Taichi K. Deguchi, Mitchel J. Cohen, Ernest E. Moore, John H. Griffin
Summary: Lower levels of plasma full-SkM are associated with coagulopathy in acutely injured trauma patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
C. P. D. M. de Breet, S. Zwaveling, M. J. A. Vries, R. G. van Oerle, Y. M. C. Henskens, A. W. J. Van't Hof, P. E. J. van der Meijden, L. Veenstra, H. ten Cate, R. H. Olie
Summary: Thrombin generation measurement in plasma may provide additional insight into bleeding risk assessment for high clinical-risk patients using dual antiplatelet therapy. The reduced and delayed thrombin generation in platelet-poor plasma, possibly due to variation in coagulation factors, increases the bleeding risk in these patients. Monitoring thrombin generation has the potential to improve the identification of patients with increased risk of bleeding while on dual antiplatelet therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Elena Campello, Alberto Zanetto, Cristiana Bulato, Sara Maggiolo, Luca Spiezia, Francesco Paolo Russo, Sabrina Gavasso, Pierluigi Mazzeo, Daniela Tormene, Patrizia Burra, Paolo Angeli, Marco Senzolo, Paolo Simioni
Summary: This study investigated coagulation alterations in ACLF patients compared to AD patients, finding that ACLF patients had lower platelet count, longer INR and activated partial thrombin time. ROTEM results indicated a more pronounced hypocoagulable state in ACLF patients. No correlation was found between these alterations and bleeding complications.
LIVER INTERNATIONAL
(2021)
Review
Hematology
Nikolaus B. Binder, Francois Depasse, Julia Mueller, Thomas Wissel, Stephan Schwers, Matthias Germer, Bjorn Hermes, Peter L. Turecek
Summary: TGA is a global assay that allows for the dynamic and continuous recording of both thrombin generation and inactivation effects. It is widely used in clinical medicine for the diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Anesthesiology
Patricia Guilabert, Lars Asmis, Vicente Cortina, Joan P. Barret, Maria J. Colomina
Summary: Factor XIII (FXIII) is the final factor in the coagulation cascade and its deficiency can lead to surgical bleeding. Congenital FXIII deficiency is rare, while acquired FXIII deficiency is more common. This review provides guidance on the diagnosis and treatment of FXIII deficiency in preoperative consultation and surgical settings.
MINERVA ANESTESIOLOGICA
(2022)
Review
Hematology
Christine Lodberg Hvas, Julie Brogaard Larsen, Kasper Adelborg, Steffen Christensen, Anne-Mette Hvas
Summary: ICU COVID-19 patients have a high risk of thrombosis, with impaired coagulation and fibrinolysis function. Increased thrombin generation and decreased fibrinolysis may contribute to the development of thrombosis.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Health Care Sciences & Services
Liliana Vecerzan, Ariela Olteanu, Ionela Maniu, Adrian Boicean, Calin Remus Cipaian, Horatiu Dura, Sorin Radu Fleca, Romeo Gabriel Mihaila
Summary: This study analyzed thrombin generation in patients with chronic liver disease and found that it was lower compared to controls, decreasing as the disease progressed. These findings suggest that thrombin generation assays could help identify patients at high thrombotic and hemorrhagic risk and guide personalized treatment.
Article
Hematology
Bosko M. Stojanovski, Enrico Di Cera
Summary: A plasma assay has been developed that directly monitors prothrombin activation without the need for fluorogenic substrates. The availability of factor V in plasma strongly influences the rate of prothrombin activation, while deficiencies in FVIII and FIX significantly slow down the cleavage of prothrombin. The assay is sensitive enough to assess how deficiencies in coagulation factors affect thrombin formation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Orthopedics
Cheng-cheng Zhao, Li-yile Chen, Chang-jun Chen, Qiu-ru Wang, Qian-hao Li, Peng-de Kang
Summary: This study compared blood loss and indicators of coagulation and fibrinolysis between total knee arthroplasty (TKA) patients living at low or high altitudes. The results showed that total blood loss was significantly higher in the high-altitude group compared to the low-altitude group. The high-altitude group also exhibited prolonged coagulation parameters and increased levels of fibrinogen/fibrin degradation product. Ecchymosis was more frequent in the high-altitude group. However, transfusion rates and incidence of thromboembolic events and complications were similar between the two groups.
INTERNATIONAL ORTHOPAEDICS
(2023)
Review
Cardiac & Cardiovascular Systems
Lars L. F. G. Valke, Sanna Rijpma, Danielle Meijer, Saskia E. M. Schols, Waander L. van Heerde
Summary: The treatment of bleeding and thrombotic disorders can be personalized through the use of global assays such as thrombin generation assays (TGAs). These assays can help identify patients with more severe bleeding phenotypes and guide non-replacement therapy and bypassing therapy. They also have a potential role in monitoring antithrombotic therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jean H. T. Daemen, Samuel Heuts, Ashkan Rezazadah Ardabili, Jos G. Maessen, Karel W. E. Hulsewe, Yvonne L. J. Vissers, Erik R. de Loos
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Nadine A. Coorens, Jean H. T. Daemen, Cornelis H. Slump, Nicky Janssen, Yanina Jansen, Jos G. Maessen, Yvonne L. J. Vissers, Karel W. E. Hulsewe, Erik R. de Loos
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Mariani, Bas C. T. van Bussel, Justine M. Ravaux, Maaike M. Roefs, Maria Elena De Piero, Michele Di Mauro, Anne Willers, Patrique Segers, Thijs Delnoij, Iwan C. C. van der Horst, Jos Maessen, Roberto Lorusso
Summary: The in-hospital and postdischarge mortality rates after postcardiotomy ECMO in adults are high in the Netherlands. Older age and higher body mass index are associated with higher in-hospital mortality, while postoperative renal failure, respiratory failure, and re-thoracotomy are associated with 12-month postdischarge mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Letter
Cardiac & Cardiovascular Systems
E. R. Kurniawati, P. W. Weerwind, J. G. Maessen
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicky Janssen, Jean H. T. Daemen, Iris L. Michels, Aimee J. P. M. Franssen, Jos G. Maessen, Karel W. E. Hulsewe, Yvonne L. J. Vissers, Erik R. de Loos
Summary: This study aims to quantify the incidence of clinically relevant intrathoracic abnormalities found incidentally using conventional CT in pectus excavatum patients. The results showed that only 0.5% of patients had clinically relevant abnormalities requiring additional diagnostics, supporting the replacement of CT and plain radiographs by 3D-surface scanning in the preoperative work-up for pectus excavatum repair.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Orlando Parise, Gianmarco Parise, Akshayaa Vaidyanathan, Mariaelena Occhipinti, Ali Gharaviri, Cecilia Tetta, Elham Bidar, Bart Maesen, Jos G. Maessen, Mark La Meir, Sandro Gelsomino
Summary: This study aimed to develop an effective machine learning prediction model for postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG) and identify the most relevant clinical factors. Four machine learning algorithms were compared, and the Random Forest model showed the best performance. Age, preoperative creatinine values, time of aortic cross-clamping, body surface area, and Logistic Euro-Score were found to be the top predictive features for POAF.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel Heuts, Anina F. van de Koolwijk, Andrea Gabrio, Johannes F. H. Ubben, Iwan C. C. van der Horst, Thijs S. R. Delnoij, Martje M. Suverein, Jos G. Maessen, Roberto Lorusso, Marcel C. G. van de Poll
Summary: This study presents a Bayesian re-analysis of the multicentre INCEPTION trial, which compared extracorporeal cardiopulmonary resuscitation (ECPR) with conventional cardiopulmonary resuscitation (CCPR) in patients with refractory out-of-hospital cardiac arrest. The results show that ECPR had a slightly better effect on 30-day survival with a favourable neurologic outcome compared to CCPR, with a 42% probability of meeting the minimal clinically important difference.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Claudia A. J. van der Heijden, Vanessa Weberndoerfer, Mindy Vroomen, Justin G. Luermans, Sevasti-Maria Chaldoupi, Elham Bidar, Kevin Vernooy, Jos G. Maessen, Laurent Pison, Sander M. J. van Kuijk, Mark La Meir, Harry J. G. M. Crijns, Bart Maesen
Summary: This study compared the effectiveness and safety of hybrid ablation (HA) and catheter ablation (CA) in the treatment of patients with persistent atrial fibrillation (AF). After 12 months of follow-up, the HA group had a higher freedom rate from atrial tachyarrhythmias off antiarrhythmic drugs. HA is an efficacious and safe procedure that yields better outcomes than CA for patients with persistent AF.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Berta H. Ganizada, Koen D. Reesink, Shaiv Parikh, Mitch J. F. G. Ramaekers, Asim C. Akbulut, Pepijn J. M. H. Saraber, Gijs P. Debeij, Ehsan MUMC TAA Student Team, Armand M. Jaminon, Ehsan Natour, Roberto Lorusso, Joachim E. Wildberger, Barend Mees, Geert Willem Schurink, Michael J. Jacobs, Jack Cleutjens, Ingrid Krapels, Alexander Gombert, Jos G. Maessen, Ryan Accord, Tammo Delhaas, Simon Schalla, Leon J. Schurgers, Elham Bidar
Summary: Current management guidelines for ascending thoracic aortic aneurysms (aTAA) suggest intervention once the diameter reaches 5-5.5 cm or shows a growth rate of >0.5 cm/year. However, aTAA dissections (aTAAD) often occur in vessels with diameters below the surgical intervention threshold. To improve understanding of aTAA pathophysiology, the MAPEX platform focuses on the interactions between vascular smooth muscle cells and extracellular matrix, aiming to narrow knowledge gaps and improve diagnostic and prognostic possibilities.
Article
Cardiac & Cardiovascular Systems
Bart Scheenstra, Bart C. Bongers, Britney Broeders, Maike Imkamp, Lieke Van Susante, Bas Kietselaer, Jos Maessen, Arnoud Van'T Hof, Peyman Sardari Nia
Summary: Prehabilitation through a digital platform can improve the physical and mental fitness of cardiothoracic surgery patients, leading to better treatment outcomes. This study aimed to identify the reasons and predictors of non-participation in a personalized digital prehabilitation care trial. The results showed that age, socioeconomic status, smoking, and EuroSCORE II were independent predictors of non-participation.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicky Janssen, Jean H. T. Daemen, Iris L. Michels, Aimee J. P. M. Franssen, Jos G. Maessen, Karel W. E. Hulsewe, Yvonne L. J. Vissers, Erik R. de Loos
Summary: The prevalence of clinically relevant intrathoracic abnormalities in pectus excavatum patients was low, supporting the notion that CT and plain radiographs can be safely replaced by 3D-surface scanning in the preoperative work-up for pectus excavatum repair.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Michal J. Kawczynski, Peyman Sardari Nia, Jos G. Maessen, Giuseppe Biondi-Zoccai, Andrea Gabrio
Summary: This study found that TAVR may no longer be non-inferior to SAVR in terms of 5-year all-cause mortality.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Andrea Gabrio, Leo Veenstra, Bart Maesen, Suzanne Kats, Jos G. Maessen, Antony S. Walton, Shane Nanayakkara, Alexandra J. Lansky, Arnoud W. J. van 't Hof, Pieter A. Vriesendorp
Summary: A systematic review and Bayesian meta-analysis of randomised cerebral embolic protection (CEP) trials during transcatheter aortic valve implantation (TAVI) suggests a high probability of treatment effect but an unlikely clinical relevance.
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Angelique Ceulemans, Gerhardus J. A. J. M. Kuiper, Jan U. Schreiber, Bernard J. van Varik, Renske H. Olie, Hugo Ten Cate, Jos G. Maessen, Milan Milojevic, Bart Maesen
Summary: Management of patients on direct oral anticoagulants (DOACs) undergoing surgery varies depending on the urgency of the case. For elective and urgent cases, DOAC cessation should be adjusted based on renal function, with potential additional monitoring tests. In emergency cases, idarucizumab can be safely used for patients on dabigatran, while caution should be taken with the use of andexanet alfa for factor Xa inhibitors. Consideration of (activated) prothrombin complex concentrate is recommended for all DOAC patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Umar Imran Hamid, Thomas Modine, Jos Maessen, Arnoud van't Hof, Lars Sondergaard, Sabine Bleiziffer, Patrizio Lancellotti, Matthias Siepe, Peyman Sardari Nia
Summary: This survey investigates the real-world practice of heart teams in Europe and highlights significant variability in infrastructure and execution among different institutions. The results suggest a need to formulate guidelines for the composition and execution of heart teams, which could improve transparency in decision-making and outcomes reporting and comparison across institutions.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)