Article
Biochemistry & Molecular Biology
Leonardo Pazarin-Villasenor, Yessica Garcia-Salas, Francisco Gerardo Yanowsky-Escatell, Fermin Paul Pacheco-Moises, Jorge Andrade-Sierra, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Andres Garcia-Sanchez, Alejandra Guillermina Miranda-Diaz
Summary: This study investigated the oxidative stress status in peritoneal dialysis patients with type 2 diabetes mellitus. The levels of lipoperoxides and oxidative DNA damage markers were found to be significantly increased in patients with and without diabetes, while the activity of antioxidant enzymes was also increased. Antioxidant enzymes could be a promising therapeutic strategy for the management of chronic kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Li-Ying He, Yong Li, Shu-Qi Niu, Jing Bai, Si-Jing Liu, Jin-Lin Guo
Summary: Diabetes mellitus is a metabolic disease characterized by high blood sugar levels. Oxidative stress plays a significant role in its development, especially in type 2 diabetes and metabolic syndrome. Natural polysaccharides, derived from plants, microorganisms, and marine organisms, have been found to have antioxidant activity and therapeutic effects in diabetes. This paper summarizes the natural polysaccharides with therapeutic potential for diabetes in the past 5 years, providing insights into their pharmacological mechanisms and identified structures, which can be valuable for the development of new diabetic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
George-Alexandru Maftei, Maria-Alexandra Martu, Marius-Cristian Martu, Dora Popescu, Petra Surlin, Diana Tatarciuc, Cristina Popa, Liliana-Georgeta Foia
Summary: The study showed that various oxidative status markers and proinflammatory biomarkers in the saliva of diabetic patients were altered before and after tooth extraction, correlating with HbA1c levels and potentially serving as indicators of post-extraction healing status in the oral cavity.
Review
Biochemistry & Molecular Biology
Rosaria Vincenza Giglio, Anca Pantea Stoian, Martin Haluzik, Kalliopi Pafili, Angelo Maria Patti, Ali Abbas Rizvi, Marcello Ciaccio, Nikolaos Papanas, Manfredi Rizzo
Summary: Diabetes is a major risk factor for cardiovascular disease, with high blood glucose leading to increased reactive oxygen species and affecting endothelial function and atherosclerotic plaque formation. Biomarkers play a crucial role in screening, prediction, diagnosis, and monitoring of cardiovascular risks associated with diabetes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Review
Biochemistry & Molecular Biology
Anju Singh, Ritushree Kukreti, Luciano Saso, Shrikant Kukreti
Summary: Oxidative stress is a metabolic dysfunction caused by the imbalance between reactive oxygen species production and the body's antioxidant defense system. It is closely related to the development of various noncommunicable diseases. Diabetes mellitus, especially type 2 diabetes, is significantly influenced by oxidative stress, which plays a crucial role in insulin signaling pathways.
Review
Nutrition & Dietetics
Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
Summary: Diabetes is a chronic disease with a high health burden primarily caused by mortality or morbidity from vascular complications. Prolonged hyperglycemia leads to abnormal metabolism and the formation of advanced glycation end products (AGEs). The interaction between AGEs and their receptors promotes oxidative stress and inflammation through multiple pathways.
Article
Biochemistry & Molecular Biology
Zhu Zeng, Yi Yang, Xinxin Zhong, Fangyin Dai, Shangwu Chen, Xiaoling Tong
Summary: This study investigated the beneficial effects of Lactobacillus paracasei strain L14 on type 2 diabetes mellitus (T2DM) rats. The preventive supplementation of strain L14 showed excellent anti-diabetic effects, reducing hyperglycemia, protecting pancreatic beta-cell and liver function, and improving dyslipidemia and inflammation. The strain also modulated the gut microbiota to alleviate gut dysbiosis. The whole-genome sequencing of L14 identified genes related to antioxidant systems and other beneficial microbial metabolites, highlighting its potential applications in functional food and pharmaceutical industries.
Article
Plant Sciences
Feng Zhang, Dan Chen, Liming Zhang, Qingyujing Zhao, Yage Ma, Xi Zhang, Shenglan Zhao, Chaoyin Chen
Summary: The study found that diaphragma juglandis extract could improve metabolic abnormalities in type 2 diabetic rats, including insulin resistance, abnormal lipid metabolism, liver damage, oxidative stress, and reduce inflammation. It also prevented the pathological damage of pancreas and liver, and intercepted the disorders of gut microbes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ildete L. Ferreira, Solange Costa, Bruno J. Moraes, Ana Costa, Olga Fokt, Daniela Marinho, Vera Alves, Isabel P. Baptista, A. Cristina Rego
Summary: Periodontitis (PDT) and type 2 diabetes (T2D) have a bidirectional relationship and are associated with imbalanced oxidative stress and mitochondrial dysfunction. This study investigated the mitochondrial and redox (de)regulation in peripheral blood mononuclear cells (PBMCs) of T2D-PDT, PDT, T2D patients, and control individuals. The results showed that PBMCs from T2D-PDT patients exhibited significant redox changes, while PBMCs from PDT patients showed mitochondrial deregulation and reduced expression of Nrf2-target genes.
Article
Endocrinology & Metabolism
Yao Chen, Lilin Yao, Shuheng Zhao, Mengchu Xu, Siwei Ren, Lu Xie, Lei Liu, Yin Wang
Summary: This study used machine learning to build aging and disease models, revealing a close relationship between oxidative aging and type 2 diabetes mellitus (T2DM). The results identified key factors such as nutritional metabolism, inflammation response, mitochondrial function, and protein homeostasis in the interplay between oxidative aging and T2DM. The study integrated various risk factors in T2DM and confirmed the theories of oxi-inflamm-aging and cellular senescence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sara Oliveira, Tamaeh Monteiro-Alfredo, Rita Henriques, Carlos Fontes Ribeiro, Raquel Seica, Teresa Cruz, Celia Cabral, Rosa Fernandes, Fatima Piedade, Maria Paula Robalo, Paulo Matafome, Sonia Silva
Summary: A new curcuminoid was synthesized to enhance anti-inflammatory and antioxidant potential, as well as achieve hypoglycemic and vascular protective effects in type 2 diabetic rats at lower doses compared to curcumin. Both compounds showed significant anti-inflammatory effects, with the curcuminoid exhibiting a marked hypoglycemic effect and improved vascular function in the study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)