Article
Biochemistry & Molecular Biology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs and SMCs interact through the CXCL12-CXCR4 axis to establish an amplifying feedback loop, promoting regenerative processes and mediating SMC phenotype control to potentially maintain vascular homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Joo-Hui Han, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study revealed that CIAPIN1 is overexpressed in the neointimal region, and its deficiency inhibits intimal hyperplasia and VSMC proliferation and migration while overexpression promotes these processes. CIAPIN1 negatively regulates Tp53 transcription, promoting cell cycle progression and migration, and increases JAK2 expression to enhance phenotypic switching in response to vascular injury. These findings suggest CIAPIN1 as a potential therapeutic target for vascular proliferative diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Review
Biochemistry & Molecular Biology
Yu Jiang, Hai-Yan Qian
Summary: Atherosclerosis (AS) is the accumulation of lipids and inflammatory debris in the arterial wall, leading to gradual occlusion of the arterial lumen. Despite therapeutic advances, AS remains the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, with remarkable plasticity and involvement in various processes such as phenotypic transformation, proliferation, migration, calcification, and apoptosis. Transcription factors and complex interactions of conserved cis-regulatory elements are key in the transcriptional regulation of VSMC genes, and manipulating transcription factors can regulate the development of atherosclerotic lesions.
MOLECULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cell Biology
Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong
Summary: Vascular smooth muscle cells (VSMCs) are highly plastic and can switch into synthetic VSMCs to repair vascular injury. Multiple phenotypes of VSMCs have been discovered in vascular aging, atherosclerosis, and aortic aneurysm. The transformation of VSMCs is regulated by various factors such as transcription factors, growth factors, and non-coding RNAs.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Hematology
Ashish Misra, Rajan Rehan, Alexander Lin, Sanjay Patel, Edward A. Fisher
Summary: Clonal expansion plays a crucial role in atherosclerosis, particularly in smooth muscle cells and macrophages. Recent studies have revealed the contribution of clonal expansion to disease pathology and provided innovative directions for future therapies of atherosclerosis and associated cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Floriana Maria Farina, Simone Serio, Ignacio Fernando Hall, Stefania Zani, Giada Andrea Cassanmagnago, Montserrat Climent, Efrem Civilini, Gianluigi Condorelli, Manuela Quintavalle, Leonardo Elia
Summary: DOT1L inhibition in VSMCs significantly reduces atherosclerosis progression by directly modulating Nf-kappa B1 and Nf-kappa B2 transcription, which are master regulators of inflammation inducing expression of CCL5 and CXCL10 cytokines, key in atherosclerosis development. DOT1L could be a promising therapeutic target for vascular diseases as its inhibition reduces plaque progression.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Karim J. Brandt, Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Summary: The study revealed the crucial role of GDF10 in the phenotypic switch of VSMCs, which may have a detrimental impact on the stability of atherosclerotic plaques and increase the risk of carotid artery disease (CAD) events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Alessandro L. Gallina, Urszula Rykaczewska, Robert C. Wirka, April S. Caravaca, Vladimir S. Shavva, Mohamad Youness, Glykeria Karadimou, Mariette Lengquist, Anton Razuvaev, Gabrielle Paulsson-Berne, Thomas Quertermous, Anton Gistera, Stephen G. Malin, Laura Tarnawski, Ljubica Matic, Peder S. Olofsson
Summary: Glutamate receptors and related enzymes were identified in VSMCs from human atherosclerotic lesions, with AMPA-type glutamate receptors playing a role in VSMC phenotypic modulation. Lower mRNA levels of GRIA1 and GRIA2 in atherosclerotic lesions were associated with adverse clinical events, suggesting the importance of further exploring neurotransmitter signaling in the pathogenesis of human atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Lingfeng Luo, Changhao Fu, Caitlin F. Bell, Ying Wang, Nicholas J. Leeper
Summary: Atherosclerotic cardiovascular disease is the leading cause of death worldwide, and vascular smooth muscle cell (SMC) clonality plays a significant role in its development. Currently, there are unanswered questions regarding SMC clonality, such as the existence of stem-like progenitor cells and how cells within a clone determine their phenotype. Understanding these aspects is important for the development of novel approaches to treating atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Nikolaos T. Skenteris, Till Seime, Anna Witasp, Eva Karlof, Grzegorz B. Wasilewski, Marina A. Heuschkel, Armand M. G. Jaminon, Loureen Oduor, Robert Dzhanaev, Malin Kronqvist, Mariette Lengquist, Frederique E. C. M. Peeters, Magnus Soderberg, Rebecka Hultgren, Joy Roy, Lars Maegdefessel, Hildur Arnardottir, Eva Bengtsson, Isabel Goncalves, Thomas Quertermous, Claudia Goettsch, Peter Stenvinkel, Leon J. Schurgers, Ljubica Matic
Summary: Recent studies have found a correlation between plasma and tissue levels of osteomodulin (OMD) and cardiovascular calcification, suggesting the potential of OMD as a clinical biomarker. OMD was found to be present in calcified cardiovascular tissues and was induced by pro-inflammatory and pro-osteogenic stimuli. Furthermore, the presence of OMD in the extracellular environment attenuated smooth muscle cell (SMC) calcification.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Tianbin Chen, Qingyang Liang, Jialin Xu, Yanan Zhang, Yi Zhang, Liping Mo, Li Zhang
Summary: The study found that by regulating SDC1, miR-665 inhibits the effect of the lncRNA GAS5 on VSMCs. This could provide a new treatment strategy for aging-related cardiovascular diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)