Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

The membrane topology of vitamin K epoxide reductase is conserved between human isoforms and the bacterial enzyme

(2016) Z. Cao et al.   BIOCHEMICAL JOURNAL

Membrane topology of transmembrane proteins: determinants and experimental tools

(2014) Hunsang Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration

(2014) Jian-Ke Tie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay

(2013) Carville G. Bevans et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces

(2013) K. J. Czogalla et al.   BLOOD

A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay

(2013) A. Fregin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells

(2013) J.-K. Tie et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Phycobilisomes Supply Excitations to Both Photosystems in a Megacomplex in Cyanobacteria

(2013) H. Liu et al.   SCIENCE

Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms

(2012) Jian-Ke Tie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of bone to whole-organism physiology

(2012) Gérard Karsenty et al.   NATURE

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

(2012) Thomas Walzthoeni et al.   NATURE METHODS

Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants

(2011) Ahmed Hodroge et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human Herpesvirus 8 Viral Interleukin-6 Interacts with Splice Variant 2 of Vitamin K Epoxide Reductase Complex Subunit 1

(2011) D. Chen et al.   JOURNAL OF VIROLOGY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

Interactions of Apurinic/Apyrimidinic Endonuclease with a Redox Inhibitor: Evidence for an Alternate Conformation of the Enzyme

(2010) Dian Su et al.   BIOCHEMISTRY

Novel Insight into the Mechanism of the Vitamin K Oxidoreductase (VKOR)

(2010) Mark A. Rishavy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment

(2010) M. WATZKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of a bacterial homologue of vitamin K epoxide reductase

(2010) Weikai Li et al.   NATURE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel mutations in the VKORC1 gene of wild rats and mice - a response to 50 years of selection pressure by warfarin?

(2009) Simone Rost et al.   BMC GENETICS

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

Analysis of the Membrane Topology of Transmembrane Segments in the C-terminal Hydrophobic Domain of the Yeast Vacuolar ATPase Subunit a (Vph1p) by Chemical Modification

(2008) Yanru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-invasive topology analysis of membrane proteins in the secretory pathway

(2008) Thorsten Brach et al.   PLANT JOURNAL