Article
Gastroenterology & Hepatology
Jean-Paul Motta, Simone Palese, Carmine Giorgio, Kevin Chapman, Alexandre Denadai-Souza, Perrine Rousset, David Sagnat, Laura Guiraud, Anissa Edir, Carine Seguy, Laurent Alric, Delphine Bonnet, Barbara Bournet, Louis Buscail, Cyrielle Gilletta, Andre G. Buret, John L. Wallace, Morley D. Hollenberg, Eric Oswald, Elisabetta Barocelli, Sylvie Le Grand, Bruno Le Grand, Celine Deraison, Nathalie Vergnolle
Summary: Elevated thrombin activity in the colon of Crohn's disease patients may lead to tissue damage and inflammation. Experimental evidence suggests that colonic thrombin and protease-activated receptor-1 could be potential mechanisms involved in mucosal damage and loss of function.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Cell Biology
Julian Friebel, Eileen Moritz, Marco Witkowski, Kai Jakobs, Elisabeth Straessler, Andrea Doerner, Daniel Steffens, Marianna Puccini, Stella Lammel, Rainer Glauben, Franziska Nowak, Nicolle Kraenkel, Arash Haghikia, Verena Moos, Heinz-Peter Schutheiss, Stephan B. Felix, Ulf Landmesser, Bernhard H. Rauch, Ursula Rauch
Summary: The study found that vorapaxar may reduce inflammation in atherosclerosis by inhibiting the PAR1 signaling pathway, potentially helping to lower the risk of thrombo-inflammatory events in patients.
Article
Cardiac & Cardiovascular Systems
Christine Joseph, Eva Maria Berghausen, Arnica Behringer, Bernhard Rauch, Henrik Ten Freyhaus, Leoni Luisa Gnatzy-Feik, Maximilian Krause, Dickson W. L. Wong, Peter Boor, Stephan Baldus, Marius Vantler, Stephan Rosenkranz
Summary: This study characterizes the effects of thrombin and Factor Xa on PASMCs and their involvement in pulmonary vascular remodeling through PAR-1 and PAR-2. Inhibition of PAR-1 and PAR-2 significantly reduces vascular muscularization and improves right ventricular function in PAH. These findings suggest that PARs, rather than their activators, could be potential targets for PAH treatment.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shoshana Sedley, Jeetendra Kumar Nag, Tatyana Rudina, Rachel Bar-Shavit
Summary: This study reveals the involvement of protease-activated receptor 4 (PAR(4)) in the maintenance of colon cancer stem cells. PAR(4) and PAR(2) drive the association between methyltransferase EZH2 and beta-catenin, resulting in beta-catenin methylation and suppression of its ubiquitination. This leads to increased stability and transcriptional activity of beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jeetendra Kumar Nag, Hodaya Malka, Priyanga Appasamy, Shoshana Sedley, Rachel Bar-Shavit
Summary: The essential role of G-protein coupled receptors (GPCRs) in tumor growth is recognized, yet GPCR based drugs in cancer are rare. Understanding the molecular path of a tumor driver gene may lead to the design and development of effective drugs. Several aspects of some cardinal GPCRs in tumor angiogenesis are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xin Zhuo, Yue Wu, Xiujuan Fu, Xiaoyu Liang, Yuxin Xiang, Jianbin Li, Canquan Mao, Yuhong Jiang
Summary: Inflammatory diseases are increasing globally, and COVID-19 also exhibits hyperinflammatory responses. Protease-activated receptors (PARs) are popular drug targets involved in regulating inflammatory responses in multiple systems. PARs activation has both anti-inflammatory and pro-inflammatory effects depending on the context of inflammation. Recent findings suggest that PARs also participate in COVID-19-related inflammatory cytokine release.
Article
Biochemistry & Molecular Biology
Michelle De Bruyn, Hannah Ceuleers, Nikita Hanning, Maya Berg, Joris G. De Man, Paco Hulpiau, Cedric Hermans, Ulf-Hakan Stenman, Hannu Koistinen, Anne-Marie Lambeir, Benedicte Y. De Winter, Ingrid De Meester
Summary: The study on protease activity in IBD and IBS explored cleavage patterns of bioactive peptides in colonic tissue, revealing potential therapeutic targets like thrombin, chymotrypsin-like proteases, and proteases with different specificities in acute colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jean-Paul Motta, Celine Deraison, Sylvie Le Grand, Bruno Le Grand, Nathalie Vergnolle
Summary: A new paradigm has been proposed for the treatment of inflammatory bowel diseases, focusing on tissue repair and mucosal healing in addition to resolving symptoms and inflammation. The PAR-1 antagonist has shown potential benefits in promoting mucosal repair in Crohn's disease patients, suggesting a new indication for IBD treatment.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Cell Biology
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton
Summary: The number of PAR4 receptors expressed on platelets does not vary across different genotypes, and therefore cannot explain the altered pharmacology of the rs773902 PAR4 sequence variant.
Article
Biochemistry & Molecular Biology
Xiaobin Fang, Mengmeng Li, Weiyi Zhang, Jingyi Li, Tao Zhu
Summary: Thrombin-induced mast cell activation results in the production of both pro- and anti-inflammatory mediators, involving the expression of PAR1 and PAR4 as well as activation of MAPK signaling pathways. Dual activation of mast cells occurs after thrombin stimulation.
MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vaddarahally N. Manjuprasanna, Amog P. Urs, Gotravalli V. Rudresha, Mallanayakanakatte D. Milan Gowda, Krishnegowda Jayachandra, Vilas Hiremath, Rajesh Rajaiah, Bannikuppe S. Vishwanath
Summary: The study systematically investigated the effect of plant latex proteases (PLPs) on platelet aggregation, and identified Ficus drupacea as a plant with potent pro-coagulant and thrombin-like activity. The thrombin-like cysteine protease Drupin from F. drupacea was found to induce platelet aggregation by activating intracellular signaling cascades, reducing bleeding time in mice tail. The involvement of protease-activated receptors in Drupin-induced platelet aggregation was also confirmed, showing that the activity was mediated by PAR1 and PAR4 receptors synergistically.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Hematology
Maria Selvadurai, Moeen Riaz, Sophia Xie, Andrew M. Tonkin, John J. McNeil, Paul Lacaze, Justin R. Hamilton
Summary: This article examines the association between the single-nucleotide polymorphism rs773902 and cardiovascular events and aspirin use. The results indicate that rs773902 is not significantly associated with thrombotic or bleeding events.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Elisa D'Alessandro, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, Frans A. van Nieuwenhoven
Summary: The study demonstrates that FXa induces overexpression of proinflammatory genes in human cardiac fibroblasts through PAR-1, which is the most abundant PAR isoform in this cell type.
Article
Neurosciences
Jianing Luo, Xun Wu, Haixiao Liu, Wenxing Cui, Wei Guo, Kang Guo, Hao Guo, Kai Tao, Fei Li, Yingwu Shi, Dayun Feng, Hao Yan, Guodong Gao, Yan Qu
Summary: This study investigated the protective effects of a novel PAR4 antagonist on TBI, showing that it can protect mice from TBI and inhibit inflammation. The study suggested that the Tab2/ERK/NF-kappa B signaling pathway plays a key role in this process.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson, Pieter Goossens, John H. McVey, Anthony Dorling
Summary: Research has shown that in chronic inflammation, the PAR-1 signal is crucial for granuloma formation, with this signal acting on macrophages through the activation of Thrombin. The results of the experiment indicate that Thrombin signaling significantly enhances macrophage sensitivity to IFN-γ, leading to enhanced cell polarization.
Article
Chemistry, Multidisciplinary
Nastaran Rezaei, Amir Avan, Mehran Pashirzad, Farzad Rahmani, Reyhaneh Moradi Marjaneh, Reihane Behnam-Rassouli, Mojtaba Shafiee, Mikhail Ryzhikov, Milad Hashemzehi, Fatemeh Ariakia, Amirhossein Bahreyni, Seyed Mahdi Hassanian, Majid Khazaei
DRUG AND CHEMICAL TOXICOLOGY
(2020)
Article
Cell Biology
Atena Soleimani, Fereshteh Asgharzadeh, Farzad Rahmani, Amir Ayan, Saeedeh Mehraban, Maryam Fakhraei, Mohammad Hassan Arjmand, Maryam Moradi Binabaj, Mohammad Reza Parizadeh, Gordon A. Ferns, Mikhail Ryzhikov, Amir Reza Afshari, Jalal Naghinezhad, Sayyed Hadi Sayyed-Hosseinian, Majid Khazaei, Seyed Mandi Hassanian
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Sima Seifi, Farzaneh Pouya, Mahsa Rahmani, Mehrane Mehramiz, Azam Rastgar-Moghadam, Masoumeh Gharib, Farzad Rahmani, Soodabeh Shahidsales, Seyed Mahdi Hassanian, Majid Khazaei, Parisa Dadjoo, Seyede Sara Parvin, Yeganeh Yazdinezhad, Seyed Mohammad Reza Parizadeh, Gordon A. Ferns, Mehdi Fathi, Amir Avan
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Cell Biology
Farzad Rahmani, Aghigh Ziaeemehr, Soodabeh Shahidsales, Masoumeh Gharib, Majid Khazaei, Gordon A. Ferns, Mikhail Ryzhikov, Amir Avan, Seyed M. Hassanian
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Genetics & Heredity
Atena Soleimani, Farzad Rahmani, Gordon A. Ferns, Mikhail Ryzhikov, Amir Avan, Seyed Mandi Hassanian
Article
Medicine, Research & Experimental
Farzad Rahmani, Fereshteh Asgharzadeh, Amir Avan, Farnaz Barneh, Mohammad Reza Parizadeh, Gordon A. Ferns, Mikhail Ryzhikov, Mohammad Reza Ahmadian, Elisa Giovannetti, Mohieddin Jafari, Majid Khazaei, Seyed Mahdi Hassanian
Review
Genetics & Heredity
Farzad Rahmani, Gordon A. Ferns, Sahar Talebian, Mahnaz Nourbakhsh, Amir Avan, Soodabeh Shahidsales
Article
Biochemistry & Molecular Biology
Hamideh Aboutalebi, Afsane Bahrami, Atena Soleimani, Nikoo Saeedi, Farzad Rahmani, Majid Khazaei, Hamid Fiuji, Mojtaba Shafiee, Gordon A. Ferns, Amir Avan, Seyed Mahdi Hassanian
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2020)
Review
Pathology
Hossein Abdeahad, Afsane Bahrami, Nikoo Saeedi, Mohammad Shabani, Milad Pezeshki, Majid Khazaei, Mojtaba Shafiee, Elnaz Ghorbani, Gordon A. Ferns, Saman Soleimanpour, Farzad Rahmani, Atena Soleimani, Hamid Fiuji, Mikhail Ryzhikov, Amir Avan, Seyed Mahdi Hassanian
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Pathology
Farzad Rahmani, Malihe Hasanzadeh, Seyed Mahdi Hassanian, Majid Khazaei, Habibollah Esmaily, Seyed Ami Asef-Agah, Alireza Naghipour, Gordon A. Ferns, Amir Avan
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Review
Genetics & Heredity
Farzad Rahmani, Ayda Tadayyon Tabrizi, Pedram Hashemian, Sajede Alijannejad, Hossein Ali Rahdar, Gordon A. Ferns, Seyed Mahdi Hassanian, Soodabeh Shahidsales, Amir Avan
