Article
Hematology
Marisa Ninivaggi, Romy de Laat-Kremers, Armando Tripodi, Denis Wahl, Stephane Zuily, Yesim Dargaud, Hugo ten Cate, Vera Ignjatovic, Katrien M. J. Devreese, Bas de Laat
Summary: Thrombin generation (TG) assay is a comprehensive tool for assessing hemostatic system functionality, but lack of standardization in its execution leads to poor correlation between test results. Recommendations based on survey and literature review address interlaboratory variation, aiming to harmonize methods and laboratories for supporting patient diagnosis and management with TG.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Karin P. M. van Galen, Roseline d'Oiron, Paula James, Rezan Abdul-Kadir, Peter A. Kouides, Roshni Kulkarni, Johnny N. Mahlangu, Maha Othman, Flora Peyvandi, Dawn Rotellini, Rochelle Winikoff, Robert F. Sidonio
Summary: Although female carriers (HCs) of hemophilia may be asymptomatic, they actually have a tendency to bleed. A new nomenclature has been defined based on bleeding history and baseline plasma FVIII/IX levels, distinguishing five clinically relevant categories of HCs, aiming to improve diagnosis and management.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Matthew Locke, Colin Longstaff, Peter Rigsby
Summary: The study showed that the potency estimates for the candidate replacement standard 19/188 were closer to the current standard (01/580) than those of 01/578, with low variation between and within laboratories.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Green & Sustainable Science & Technology
A. Garcia-Alaminos, E. Gilles, F. Monsalve, J. Zafrilla
Summary: The global contribution of organizations to greenhouse gas emissions is significant, and calculating, reporting, reducing, and compensating for carbon footprints are important steps towards achieving the objectives of the Paris Agreement. This paper focuses on assessing the carbon footprint of a university in Bogotá, Colombia, using a multiregional input-output framework. The results show that the majority of the institution's carbon footprint is attributed to indirect emissions in the supply chain.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The study evaluated the traditional 40/80-unit thresholds used for categorization of antiphospholipid antibodies in different analytical systems, and found that alternative thresholds can improve consistency in interpretation. By using different thresholds, the positivity levels of antiphospholipid antibodies can be more accurately assessed.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Marisol Betensky, Ketan Kulkarni, Mattia Rizzi, Sophie Jones, Leonardo R. Brandao, Edward Vincent S. Faustino, Neil A. Goldenberg, Anjali Sharathkumar
Summary: Clinically unsuspected VTE in children has limited understanding of its clinical significance due to lack of data. Further research is urgently needed to inform optimal management. This article provides guidance recommendations for standardization of definitions and identifies future research needs.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Environmental Sciences
Valeria Ibanez-Fores, Virginia Martinez-Sanchez, Karen Valls-Val, Maria D. Bovea
Summary: Sustainability reports can serve as a valuable tool in facilitating the transition towards more circular economy models for organizations. This study aims to determine the feasibility of calculating indicators that measure the level of circularity based on the information currently communicated in Corporate Sustainability Reports (CSRs). The findings suggest that a significant number of indicators can be directly measured using the information provided in CSRs.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Behavioral Sciences
Devon N. Gangi, Monique Moore Hill, Shyeena Maqbool, Gregory S. Young, Sally Ozonoff
Summary: The broader autism phenotype (BAP) includes subclinical features of autism spectrum disorder (ASD) and is more common among family members of those with ASD. School-age children with BAP characteristics exhibited lower conversational skills compared to peers, but did not show differences on standardized language measures. This suggests that naturalistic tasks may be more sensitive in identifying social-communication difficulties in children with a family history of ASD compared to standardized language tests.
Article
Hematology
Florian Puhm, Isabelle Allaeys, Emile Lacasse, Isabelle Dubuc, Yannick Galipeau, Younes Zaid, Loubna Khalki, Clemence Belleannee, Yves Durocher, Alain R. Brisson, Alisa S. Wolberg, Marc-Andre Langlois, Louis Flamand, Eric Boilard
Summary: Platelets are hyperactivated in COVID-19, but the mechanisms behind platelet activation by SARS-CoV-2 are not well understood. This study found that tissue factor (TF) produced by infected cells can activate platelets. Virions and extracellular vesicles (EVs) were also identified, and TF activity was associated with either the virus or the EVs. Blocking this pathway may interfere with platelet activation and the coagulation characteristics of COVID-19.
Article
Critical Care Medicine
Michael A. Lawson, Lori A. Holle, Nathan E. Dow, Grant Hennig, Bas de Laat, Hunter B. Moore, Ernest E. Moore, Mitchell J. Cohen, Beth A. Bouchard, Kalev Freeman, Alisa S. Wolberg
Summary: Dehydration therapy can dissolve solid substances in water and selectively absorb drug and dye substances using the suction force of colloidal particles on paper.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Review
Pharmacology & Pharmacy
Kadri Kangro, Alisa S. S. Wolberg, Matthew J. Flick
Summary: SARS-CoV-2 infection can lead to severe pathological changes including significant activation of the clotting system and thrombus formation, resulting in abnormal fibrinogen and fibrin degradation. Fibrinogen and the fibrin degradation product D-dimer may serve as biomarkers for poor prognosis in COVID-19. Emerging studies suggest that fibrinogen plays an active role in the pathogenesis of COVID-19.
CURRENT DRUG TARGETS
(2022)
Article
Hematology
Woosuk S. Hur, Katharine C. King, Yesha N. Patel, Y-Van Nguyen, Zimu Wei, Yi Yang, Lih Jiin Juang, Jerry Leung, Christian J. Kastrup, Alisa S. Wolberg, James P. Luyendyk, Matthew J. Flick
Summary: It has been found that the lack of fibrinogen with binding function to the leukocyte integrin receptor can substantially reduce obesity and associated diseases, while preventing fibrinogen polymerization or crosslinking only partially replicates this protective effect.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Anton Ilich, Terry B. Gernsheimer, Darrell J. Triulzi, Heather Herren, Siobhan P. Brown, Lori A. Holle, Andrew T. Lucas, Bas de Laat, Nahed El Kassar, Alisa S. Wolberg, Susanne May, Nigel S. Key
Summary: This study found that using TXA did not show superiority over placebo in preventing high-grade bleeding in patients with severe thrombocytopenia. The study also did not find an association between fibrinolysis assays and bleeding risk.
Article
Hematology
Steven P. Grover, Tomohiro Kawano, Jun Wan, Pansakorn Tanratana, Zsofia Polai, Young J. Shim, Omri Snir, Sigrid Braekkan, Sophia Dhrolia, Rohan R. Kasthuri, Pavan K. Bendapudi, Keith R. McCrae, Alisa S. Wolberg, John-Bjarne Hansen, Henriette Farkas, Nigel Mackman
Summary: C1INH is a serine protease inhibitor that regulates multiple biological pathways. Deficiency of C1INH is associated with hereditary angioedema (HAE) and increased risk of coagulation activation and thrombosis.
Article
Hematology
Jun Wan, Pansakorn Tanratana, Mark Roest, Andras Gruber, Rafal Pawlinski, Alisa S. Wolberg, Nigel Mackman, Steven P. Grover
Summary: This study describes a novel mouse whole blood TG assay to assess the amplifying roles of intrinsic pathway factors in mouse coagulation. The assay has enhanced sensitivity to FXI and FIX-dependent amplification of coagulation, suggesting an important role of blood cells in this process.
Article
Multidisciplinary Sciences
Emma Bouck, Marios Arvanitis, William K. Osburn, Yaqiu L. Sang, Paula J. Reventun, Homa S. Ahmadzia, Nicholas P. Smith, Charles P. Lowenstein, Alisa P. Wolberg
Summary: Oral contraceptive (OC) use increases the risk of venous thromboembolism. This study investigates the effect of OC hormones on endothelial cell (EC) procoagulant activity and the potential interaction between OC hormones and estrogen receptors and inflammation. The results show that the OC hormones ethinyl estradiol and drospirenone do not directly enhance the thrombin generation potential of primary ECs in vitro.
Article
Health Care Sciences & Services
Laurie Fraticelli, Julie Freyssenge, Emilie Prome-Combel, Eleonore Agnellet, Yesim Dargaud, Valerie Chamouard
Summary: This study aims to evaluate the impact of training programs provided to community pharmacists in the dispensing of emicizumab and assess patients' satisfaction with their treatment. The study uses the four-level Kirkpatrick evaluation model to assess the immediate reaction, knowledge acquired, professional practice, and patient satisfaction. The study includes community pharmacists and patients with severe hemophilia A, regardless of training received.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Hematology
Valerie Chamouard, Julie Freyssenge, Gaetan Duport, Fabienne Volot, Remi Varin, Nicolas Giraud, Yesim Dargaud, Laurie Fraticelli
Summary: This study evaluated the satisfaction of haemophilia A patients who chose dispensation from a community pharmacy or a hospital pharmacy. The results showed that patients were more satisfied with dispensation from a community pharmacy compared to a hospital pharmacy. Accessibility to treatment was improved, travel times were significantly reduced, and patients reported higher overall satisfaction and stronger relationships with the pharmacists.
Article
Hematology
Julie Hahn, Jan Bressler, Arce Domingo-Relloso, Ming-Huei Chen, Daniel L. McCartney, Alexander Teumer, Jenny van Dongen, Marcus E. Kleber, Dylan Aissi, Brenton R. Swenson, Jie Yao, Wei Zhao, Jian Huang, Yujing Xia, Michael R. Brown, Ricardo Costeira, Eco J. C. de Geus, Graciela E. Delgado, Dre'Von A. Dobson, Paul Elliott, Hans J. Grabe, Xiuqing Guo, Sarah E. Harris, Jennifer E. Huffman, Sharon L. R. Kardia, Yongmei Liu, Stefan Lorkowski, Riccardo E. Marioni, Matthias Nauck, Scott M. Ratliff, Maria Sabater-Lleal, Tim D. Spector, Pierre Suchon, Kent D. Taylor, Florian Thibord, David-Alexandre Tregouet, Kerri L. Wiggins, Gonneke Willemsen, Jordana T. Bell, Dorret I. Boomsma, Shelley A. Cole, Simon R. Cox, Abbas Dehghan, Andreas Greinacher, Karin Haack, Winfried Marz, Pierre-Emmanuel Morange, Jerome I. Rotter, Nona Sotoodehnia, Maria Tellez-Plaza, Ana Navas-Acien, Jennifer A. Smith, Andrew D. Johnson, Myriam Fornage, Nicholas L. Smith, Alisa S. Wolberg, Alanna C. Morrison, Paul S. de Vries
Summary: This study examined the association between DNA methylation and circulating fibrinogen levels, and identified 83 CpG sites that are associated with fibrinogen levels. These associations are partially driven by inflammatory pathways shared by both fibrinogen and CRP.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Dre'Von A. Dobson, Lori A. Holle, Feng-Chang Lin, Jennifer E. Huffman, James P. Luyendyk, Matthew J. Flick, Nicholas L. Smith, Paul S. de Vries, Alanna C. Morrison, Alisa S. Wolberg
Summary: This study aimed to understand the (patho) physiological actions of fibrinogen by characterizing the genetic contribution to its synthesis. By inducing HepG2 cells to express fibrinogen and observing the effects of small interfering RNA knockdown of different candidate genes, several genes interacting with fibrinogen production were identified. This approach can reveal cellular mechanisms of fibrinogen and fibrin(ogen)-mediated (patho) physiological mechanisms.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Stephanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H. B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Summary: This study suggests that tissue factor pathway inhibitor (TFPI) may play a role in modifying the bleeding risk in individuals with factor XI (FXI) deficiency. In vitro experiments showed that inhibition of TFPI enhanced clot formation and reduced fibrinolysis in FXI-deficient plasma, while increased TFPI had the opposite effects. Higher TFPI concentrations were observed in FXI-deficient individuals with bleeding compared to controls, and total plasma TFPI correlated with clotting and fibrinolysis parameters associated with bleeding risk. These findings indicate that TFPI may be a potential modifier of bleeding risk in FXI-deficient individuals.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Immunology
Edward M. Conway, Nigel Mackman, Ronald Q. Warren, Alisa S. Wolberg, Laurent O. Mosnier, Robert A. Campbell, Lisa E. Gralinski, Matthew T. Rondina, Frank L. van de Veerdonk, Karin M. Hoffmeister, John H. Griffin, Diane Nugent, Kyung Moon, James H. Morrissey
Summary: In this article, the authors discuss the emerging understanding of COVID-19-associated coagulopathy and the need to comprehend its cellular and molecular mechanisms. They categorize the current understanding into three main pathological mechanisms and address key questions and research gaps in order to improve diagnosis and treatment. The suitability of animal models for studying this condition is also considered.
NATURE REVIEWS IMMUNOLOGY
(2022)
Review
Hematology
Sarah Nersesian, Michelle Sholzberg, Mary Cushman, Alisa S. Wolberg
Summary: Illustrated review articles consist of capsules or panels of visuals that provide an up-to-date overview of a topic. They aim to be more accessible than traditional written reviews, facilitating effective knowledge translation and dissemination. This article summarizes the process of developing an illustrated review, emphasizes the importance of storytelling, and provides tools and resources for creating effective illustrated review articles.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
