Article
Medicine, General & Internal
Tanvi H. Patel, Ramya Bachu, Jennifer E. Naylor, Gerry Ezell
Summary: Cerebral venous sinus thrombosis (CVT) is a rare but life-threatening condition, more common in women and associated with local infection and hypercoagulable conditions. Diagnosis often involves MRI and MRV. Typical symptoms include headache, vision impairment, and nausea. Treatment usually includes anticoagulation and drugs to lower intracranial pressure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Hematology
A. S. West, M. I. Schonsted, H. K. Iversen
Summary: The circadian rhythms impact fibrinolysis and coagulation differently in cardiovascular patients compared to healthy individuals, with cardiovascular patients showing less pronounced rhythms of fibrinolysis and higher risk of blood clotting in the morning hours. Larger studies are needed to fully establish the effects of the circadian rhythm on coagulation, and there may be a need for a chrono-pharmacological approach in treating/preventing cardiovascular diseases.
THROMBOSIS RESEARCH
(2021)
Article
Medicine, General & Internal
Cosmin Adrian Teodoru, Mihnea Munteanu, Nadina Mercea, Alina Moatar, Horia Stanca, Florina Georgeta Popescu, Horatiu Dura, Adrian Hasegan, Doina Ileana Giurgiu, Maria-Emilia Cerghedean-Florea
Summary: This article presents a rare case of Superior Ophthalmic Vein Thrombosis (SOVT) that may be associated with hypercoagulable status. A 77-year-old female patient presented with eye ptosis, chemosis, and conjunctival congestion in the right eye (RE) and was found to have hypertrophy of the right ophthalmic vein and inferior rectus muscle. Further investigations revealed positive results for Factor V Leiden (heterozygous mutation) and methyl-enetetrahydrofolate reductase (MTHFR-C677T homozygous mutations). Immediate systemic treatment with steroids and anticoagulants led to gradual resolution of symptoms and improved visual acuity at follow-up.
Article
Hematology
Beate Luxembourg, Franziska Henke, Anette Kirsch-Altena, Ulrich Sachs, Bettina Kemkes-Matthes
Summary: Double heterozygotes for Factor V Leiden and Prothrombin G20210A exhibit a higher risk of venous thromboembolism in female patients compared to other genotype groups, developing VTE at a younger age. However, there is no significant difference in spontaneous VTE and arterial thromboembolic events compared to other genotypes. Deep vein thrombosis in the lower limb is the predominant VTE location in double heterozygotes.
THROMBOSIS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
An-Sofie Vandeput, Katrien Brijs, Lisa De Kock, Elien Janssens, Hilde Peeters, Peter Verhamme, Constantinus Politis
Summary: This study analyzed patients with thrombophilia undergoing oral and/or maxillofacial surgery, finding that surgery did not increase the risk of thrombosis or complications. A guideline for preoperative antithrombotic therapy for these patients was also formulated.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Hematology
Florian Appenzeller, Joerg Schmehl, Meinrad Gawaz, Iris Mueller
Summary: This case report discusses a 21-year-old male who, previously healthy, developed extensive thromboembolism in the context of asymptomatic COVID-19 infection and heterozygous factor V Leiden mutation.
Article
Cardiac & Cardiovascular Systems
Bakhtawar K. Mahmoodi, Niclas Eriksson, Gerrit J. A. Vos, Karina Meijer, Agneta Siegbahn, Stefan James, Lars Wallentin, Jurrien M. ten Berg
Summary: In patients with acute coronary syndrome, factor V Leiden mutation does not increase the risk of ST-segment-elevation myocardial infarction (STEMI) or affect peak cardiac necrosis markers levels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Hematology
Laure Morimont, Nathalie Donis, Celine Bouvy, Francois Mullier, Jean-Michel Dogne, Jonathan Douxfils
Summary: Activated protein C (APC) resistance (APCR) is a risk factor for venous thromboembolism (VTE). The most common cause is the factor V Leiden mutation, but there are other factors involved. Two types of tests are available: clotting time-based assays and thrombin generation-based assays. Clotting time-based assays are specific for detecting FV mutations, while thrombin generation-based assays can detect any type of APCR and can be used for comprehensive screening.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Laure Morimont, Nathalie Donis, Celine Bouvy, Francois Mullier, Jean-Michel Dogne, Jonathan Douxfils
Summary: This review discusses the performance of two types of tests for the detection of APCR and the appropriate situations where one should be used over the other. Clotting time-based assays are recommended for screening FV mutations, while the ETP-based APC resistance assay can be proposed as a global screening test as it assesses the entire coagulation process.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Vahideh Takhviji, Kazem Zibara, Asma Maleki, Ebrahim Azizi, Sanaz Hommayoun, Mohammadreza Tabatabaei, Seyed Esmaeil Ahmadi, Maral Soleymani, Omid Kiani Ghalesardi, Mina Farokhian, Afshin Davari, Pouria Paridar, Anahita Kalantari, Abbas Khosravi
Summary: Activated protein C resistance (APCR) due to factor V Leiden (FVL) mutation is a major risk factor for venous thromboembolism. In this study, APCR was found to be significantly more likely in men than women, with APCR patients having a higher risk of DVT and PE compared to the control group. However, APCR was not found to be an independent risk factor for arterial thrombosis or pregnancy complications, and patients with APCR showed lower levels of protein C and S compared to controls.
THROMBOSIS JOURNAL
(2021)
Article
Multidisciplinary Sciences
Emma F. Magavern, Damian Smedley, Mark J. Caulfield
Summary: This study found that multimorbidity, estrogen use, and Factor V Leiden (FVL) are independent risk factors for venous thromboembolism (VTE). The prevalence of VTE is associated with obesity, hypertension, dyslipidemia, chronic kidney disease, estrogen use, and the presence of FVL.
Article
Health Care Sciences & Services
Petra Riedlova, Dagmar Kramna, Silvie Ostrizkova, Hana Tomaskova, Vitezslav Jirik
Summary: Screening for factor V Leiden and factor II prothrombin in young women using ddPCR may effectively prevent TED and be cost-effective in the Czech Republic. The cost-benefit analysis suggests that screening for these genetic risk factors before starting OCs could significantly reduce treatment costs associated with TED.
Review
Cardiac & Cardiovascular Systems
Daria Eppenberger, Henning Nilius, Betsy Anagnostelis, Carola A. Huber, Michael Nagler
Summary: This study aimed to summarize and evaluate the association between heterozygous FVL mutation and recurrent VTE. The study found that heterozygous FVL mutation increased the risk of recurrent VTE, but its impact was marginal in the presence of other known risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ricardo Lugo, Fawaz Alotaibi, Brett Shirley, Dongsoo David Kim, Paul Covello, Stavan Patel
Summary: Patients with hypercoagulable disorders present an increased risk of coagulation in the perioperative period, with factor V Leiden patients successfully undergoing free tissue transfer for head and neck defects needing to consider the patient's medical history and available treatment adjuncts.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2021)
Article
Surgery
Nicole E. Speck, Peter Hellstern, Jian Farhadi
Summary: Advancements in surgery and technology have made microsurgical breast reconstruction widely adopted. However, the perioperative management of patients with hemostatic disorders remains uncertain. This study combined literature review and retrospective chart review to identify various disorders associated with thrombotic and hemorrhagic complications in patients undergoing microsurgical breast reconstruction. A standardized risk assessment and management strategy was developed in cooperation with a hematologist.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Charlotte Desprez, Henri Damon, Guillaume Meurette, Diane Mege, Jean-Luc Faucheron, Charlene Brochard, Elsa Lambrescak, Guillaume Gourcerol, Francois Mion, Vincent Wyart, Igor Sielezneff, Laurent Siproudhis, Isabelle Etienney, Nadine Ajamie, Paul-Antoine Lehur, Thomas Duflot, Valerie Bridoux, Anne-Marie Leroi
Summary: The effectiveness of sacral nerve modulation (SNM) was assessed in a large cohort of patients implanted for at least 10 years. The study found that approximately half of the patients with fecal incontinence maintained long-term efficacy after SNM treatment.
Article
Medical Laboratory Technology
Guillaume Feugray, Fiston Kasonga, Pierre Chamouni, Virginie Barbay, Marielle Fresel, Marie Helene Chretien, Sabine Brunel, Eronique Le Cam Duchez, Paul Billoir
Summary: This study investigated the impact of FXII deficiency on thrombin generation and found that thrombin generation profiles were not sensitive to FXII deficiency. The results showed that TGA could distinguish bleeding and thrombotic tendencies in FXII deficiency.
CLINICAL BIOCHEMISTRY
(2022)
Article
Hematology
Gregoire Detriche, Nicolas Gendron, Aurelien Philippe, Maxime Gruest, Paul Billoir, Elisa Rossi, Coralie L. Guerin, Anna Lokajczyk, Severine Brabant, Dominique Prie, Tristan Mirault, David M. Smadja
Summary: Gonadotropins increase ECFC-related angiogenesis and may be involved in thrombin generation in cardiovascular disease. Gonadotropins may act as biomarkers; moreover, we hypothesize that gonadotropin-blocking strategies may be a novel interesting therapeutic approach in atherosclerotic cardiovascular disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Frederic Roca, Michele Iacob, Thomas Duflot, Nathalie Donnadieu, Caroline Thill, Jeremy Bellien, Robinson Joannides
Summary: Heart rate reduction may increase arterial wall energy dissipation, but this effect may be influenced by age. Older individuals have poorer arterial stiffness and cardiovascular coupling, and lower energy dissipation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Thomas Duflot, Tony Pereira, Marie-Pierre Tavolacci, Robinson Joannides, Frederic Aubrun, Fabien Lamoureux, Virginie Eve Lvovschi
Summary: This study evaluated the pharmacokinetics of nebulized morphine compared to intravenous administration, finding significantly lower morphine doses and metabolite concentrations in the NEB group compared to the i.v. group. While there is room for improvement in bioavailability, nebulized morphine administration using routine devices was deemed suitable for morphine titration. Administration route and sex were found to significantly influence morphine and metabolite pharmacokinetics.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Paul Billoir, Perrine Lepretre, Caroline Thill, Jeremy Bellien, Veronique Le Cam Duchez, Jean Selim, Fabienne Tamion, Thomas Clavier, Emmanuel Besnier
Summary: This study found that coagulation disorders are common in COVID-19 patients, and immature platelets are early predictors of severe worsening. It suggests the key role of thrombopoiesis in the adaptation to SARS-CoV-2 infection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthieu Leuillier, Thomas Duflot, Severine Menoret, Hind Messaoudi, Zoubir Djerada, Deborah Groussard, Raphael G. P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiebaut, Isabelle Schmitz-Afonso, Severine Nobis, Cynthia Campart, Tiphaine Henry, Camille Sautreuil, Serge H. Luquet, Olivia Beseme, Catherine Feliu, Helene Peyret, Lionel Nicol, Jean-Paul Henry, Sylvanie Renet, Paul Mulder, Debin Wan, Laurent Tesson, Jean-Marie Heslan, Angeline Duche, Sebastien Jacques, Frederic Ziegler, Valery Brunel, Gilles J. P. Rautureau, Christelle Monteil, Jean-Luc do Rego, Jean-Claude do Rego, Carlos Afonso, Bruce Hammock, Anne-Marie Madec, Florence Pinet, Vincent Richard, Ignacio Anegon, Christophe Guignabert, Christophe Morisseau, Jeremy Bellien
Summary: The physiological role of the N-terminal phosphatase activity (sEH-P) of soluble epoxide hydrolase (sEH-H) was investigated using CRISPR/Cas9 to generate a knock-in (KI) rat line lacking sEH-P activity. The study found that sEH-P KI rats exhibited decreased metabolism of lysophosphatidic acids, decreased weight and fat mass gain, and increased insulin sensitivity. Moreover, sEH-P KI rats showed increased lipolysis and enhanced energy expenditure, which potentiated brown adipose thermogenesis. Additionally, sEH-P KI rats fed a high-fat diet did not experience weight gain, fat mass accumulation, insulin resistance, or hepatic steatosis, and they also exhibited enhanced cardiac mitochondrial activity and protection against ischemia-reperfusion injury. Overall, the findings highlight the importance of sEH-P in energy and fat metabolism and its potential therapeutic significance in the management of obesity and cardiac complications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Guillaume Gourcerol, Celine Savoye-Collet, Valerie Bridoux, Thomas Duflot, Anne-Marie Leroi
Summary: This study investigated the relationship between anal sphincter function and faecal incontinence (FI) subtypes, finding that the anal sphincter distensibility index (DI) using the EndoFLIP(R) system displayed poor predictive performance in distinguishing among FI subtypes.
COLORECTAL DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Paul Billoir, Thomas Elie, Jerrold H. Levy, Emmanuel Besnier, Bertrand Dureuil, Benoit Veber, Veronique Le Cam-Duchez, Thomas Clavier
Summary: This study evaluated the correlation between aPTT, anti-Xa activity, and thrombin generation in UFH-treated ICU patients. The results showed that aPTT and anti-Xa activity were correlated with thrombin generation and inflammatory response, but the correlation was higher with anti-Xa activity compared to aPTT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guillaume Feugray, Tony Pereira, Michele Iacob, Lucile Moreau-Grange, Gaetan Prevost, Valery Brunel, Robinson Joannides, Jeremy Bellien, Thomas Duflot
Summary: This study found that there were no significant differences in ARA metabolite levels between T2D patients and healthy volunteers, but HTN patients showed alterations in ARA metabolite correlation patterns with increased 20-, 19-, 15-, and 8-HETE. Additionally, a decrease in 20-HETE was observed during both hyperglycemic and hyperinsulinemic clamps, suggesting a potential link to glucose tolerance and insulin signaling regulation.
Article
Pharmacology & Pharmacy
Pierre Bourgoin, Jules Lecomte, Mehdi Ouahla, Lionel Berthomieu, Tony Pereira, Emeline Davril, Fabien Lamoureux, Nicolas Joram, Alexis Chenouard, Thomas Duflot
Summary: This study aimed to investigate the pharmacokinetics (PK) of levosimendan (LVSMD) and its metabolites, and assess the effects of ECMO on PK parameters. Results showed that ECMO altered PK parameters for LVSMD and its metabolites. Therefore, in ECMO patients, extending the infusion time of LVSMD and increasing the dose slightly may promote the synthesis of the active metabolite OR-1896, thus enhancing the long-term efficacy of LVSMD.
CLINICAL PHARMACOKINETICS
(2023)
Correction
Pharmacology & Pharmacy
Pierre Bourgoin, Jules Lecomte, Mehdi Oualha, Lionel Berthomieu, Tony Pereira, Emeline Davril, Fabien Lamoureux, Nicolas Joram, Alexis Chenouard, Thomas Duflot
CLINICAL PHARMACOKINETICS
(2023)
Article
Anesthesiology
Zoe Demailly, Veronique Wurtz, Virginie Barbay, Elisabeth Surlemont, Vincent Scherrer, Paul Billoir, Thomas Clavier, Emmanuel Besnier
Summary: This study compared the performances of ROTEM sigma, TEG 6S, and Quantra, three modern viscoelastic testing devices, and found that they performed similarly for platelet count and residual circulating heparin detection, but TEG 6S had weaker correlation with fibrinogen assay.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Cell Biology
Matthieu Leuillier, Valentin Platel, Ly Tu, Guillaume Feugray, Raphael Thuillet, Deborah Groussard, Hind Messaoudi, Mina Ottaviani, Mustapha Chelgham, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Christophe Morisseau, Valery Brunel, Thomas Duflot, Christophe Guignabert, Jeremy Bellien
Summary: Inhibitors of soluble epoxide hydrolase (sEH) present an opportunity for developing oral drugs for cardiovascular and inflammatory diseases. However, the administration of sEH inhibitors may lead to the development of pulmonary hypertension (PH). This study evaluated the impact of chronic oral administration of the sEH inhibitor TPPU on hemodynamics and pulmonary vascular remodeling in rats. The results showed that TPPU did not induce or aggravate PH and RV dysfunction, and may have a potential beneficial effect against pulmonary artery remodeling in humans.
Article
Medical Laboratory Technology
Marc Michel Noel, Guillaume Feugray, Fiston Kasonga, Gerard Buchonnet, Sylvie Daliphard, Virginie Barbay, Elsa Bera, Veronique Le Cam Duchez, Paul Billoir
Summary: This study compared the variability of immature platelets (IP) in EDTA and citrate samples, and evaluated their stability over time. The results showed that IP measurements in EDTA samples remained relatively stable within 24 hours, and IPF measurements in citrate samples remained relatively stable within 6 hours.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)