Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance
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Title
Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance
Authors
Keywords
Silibinin, Flavonolignans, Apoptosis, Cell cycle arrest, Anti-angiogenesis, Anti-metastasis, Clinical studies
Journal
SEMINARS IN CANCER BIOLOGY
Volume 73, Issue -, Pages 196-218
Publisher
Elsevier BV
Online
2020-10-29
DOI
10.1016/j.semcancer.2020.09.014
References
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Note: Only part of the references are listed.- Inhibition of urinary bladder cancer cell proliferation by silibinin
- (2020) Tatiane M. B. Barros et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironment
- (2020) Min Jiang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation
- (2020) Meirong Huo et al. JOURNAL OF CONTROLLED RELEASE
- Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
- (2020) Dominique Delmas et al. MOLECULES
- Clinical outcome of breast cancer in carriers of BRCA1 and BRCA2 mutations according to molecular subtypes
- (2020) Solene De Talhouet et al. Scientific Reports
- Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis
- (2020) Ying Liu et al. JOURNAL OF NANOBIOTECHNOLOGY
- Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer
- (2020) Yanting You et al. Frontiers in Pharmacology
- Estrogen receptors participate in silibinin-caused nuclear translocation of apoptosis-inducing factor in human breast cancer MCF-7 cells
- (2020) Weiwei Liu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
- (2020) Uttam Sharma et al. Translational Oncology
- Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment
- (2019) Lingling Si et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells
- (2019) Silvia Zappavigna et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR‐125b/miR‐182 in human breast cancer cells
- (2019) Samaneh Hossainzadeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review
- (2019) Vahid Soleimani et al. PHYTOTHERAPY RESEARCH
- The Dark That Matters: Long Non-coding RNAs as Master Regulators of Cellular Metabolism in Non-communicable Diseases
- (2019) Alessia Mongelli et al. Frontiers in Physiology
- Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation
- (2019) Anjali Takke et al. Nanomedicine-Nanotechnology Biology and Medicine
- Silibinin inhibited autophagy and mitochondrial apoptosis in pancreatic carcinoma by activating JNK/SAPK signaling
- (2019) Xiaokai Zhang et al. PATHOLOGY RESEARCH AND PRACTICE
- Circulating microRNA‐590‐5p acts as a liquid biopsy marker in non‐small cell lung cancer
- (2019) Akanksha Khandelwal et al. CANCER SCIENCE
- SNHG12: An LncRNA as a Potential Therapeutic Target and Biomarker for Human Cancer
- (2019) Suraksha Tamang et al. Frontiers in Oncology
- Sustained release of silibinin‐loaded chitosan nanoparticle induced apoptosis in glioma cells
- (2019) Maryam Alipour et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- miR‐200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer
- (2019) Hailin Tang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion
- (2019) Lingling Si et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Metabolism, Transport and Drug–Drug Interactions of Silymarin
- (2019) Xie et al. MOLECULES
- Silibinin declines blue light-induced apoptosis and inflammation through MEK/ERK/CREB of retinal ganglion cells
- (2019) Ying Shen et al. Artificial Cells Nanomedicine and Biotechnology
- Role of silibinin in the management of diabetes mellitus and its complications
- (2018) Chun Chu et al. ARCHIVES OF PHARMACAL RESEARCH
- Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT
- (2018) Jie Mao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
- (2018) Daniela Catanzaro et al. FITOTERAPIA
- Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies
- (2018) Zhong-Wen Yuan et al. PHARMACOLOGICAL RESEARCH
- Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats
- (2018) W. W. Tong et al. Scientific Reports
- Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP
- (2018) Zhuan-Li Bai et al. Biomed Research International
- Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway
- (2018) Xiaoying Hou et al. Frontiers in Pharmacology
- In vivo anticlastogenic effect of silymarin from milk thistle Silybum marianum L.
- (2018) Sirajudheen Anwar et al. INDIAN JOURNAL OF PHARMACOLOGY
- The miR-15a/16 gene cluster in human cancer: A systematic review
- (2018) Ting Liu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
- (2018) Jacob O'Brien et al. Frontiers in Endocrinology
- Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy
- (2018) Akshay Malhotra et al. BIOCHIMIE
- Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator
- (2018) Zohreh Jahanafrooz et al. LIFE SCIENCES
- Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation
- (2018) Zhengzheng Shi et al. LIFE SCIENCES
- Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway
- (2018) Rongjuan Zheng et al. MEDIATORS OF INFLAMMATION
- A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties
- (2018) Valeria Romanucci et al. MOLECULES
- Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double-blind, placebo-controlled clinical trial
- (2018) Hedyieh Karbasforooshan et al. PHYTOTHERAPY RESEARCH
- Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells
- (2018) Shanaya Patel et al. Scientific Reports
- Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for Silybin Delivery: Formulation, Characterization, and In vitro Evaluation
- (2018) Vieri Piazzini et al. Current Drug Delivery
- Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional PEG-chitosan stabilized silybin nanocrystals
- (2018) Yangyang Liu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer
- (2018) Shaheen Mahira et al. BIOMEDICINE & PHARMACOTHERAPY
- A new drug nanocrystal self-stabilized Pickering emulsion for oral delivery of silybin
- (2017) Tao Yi et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling
- (2017) Je-Won Ko et al. FOOD AND CHEMICAL TOXICOLOGY
- miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer
- (2017) Michaela Strotbek et al. INTERNATIONAL JOURNAL OF CANCER
- Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells
- (2017) Jiyeon Ham et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Mechanistic insight into carnosol-mediated pharmacological effects: Recent trends and advancements
- (2017) Dharambir Kashyap et al. LIFE SCIENCES
- Matrix metallopeptidase 9 targeted by hsa-miR-494 promotes silybin-inhibited osteosarcoma
- (2017) Tianhao Sun et al. MOLECULAR CARCINOGENESIS
- Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism
- (2017) Michal Bijak MOLECULES
- Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer
- (2017) C. Miethe et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Silibinin downregulates MMP2 expression via Jak2/STAT3 pathway and inhibits the migration and invasive potential in MDA-MB-231 cells
- (2017) Hyo Joo Byun et al. ONCOLOGY REPORTS
- Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling
- (2017) Arpit Dheeraj et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Topical Silymarin Administration for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
- (2017) Sepideh Elyasi et al. PHYTOTHERAPY RESEARCH
- Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade
- (2017) Eun-Sun Choi et al. CELLULAR ONCOLOGY
- Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability
- (2017) Muhammad Umar Khayam Sahibzada et al. Drug Design Development and Therapy
- Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models
- (2017) Michal Bijak et al. Nutrients
- The regulatory roles of long non-coding RNAs in the development of chemoresistance in breast cancer
- (2017) Akshay Malhotra et al. Oncotarget
- Regorafenib in combination with silybin as a novel potential strategy for the treatment of metastatic colorectal cancer
- (2017) Valentina Belli et al. Oncotarget
- Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways
- (2017) Mitsuho Imai-Sumida et al. Oncotarget
- Silibinin: an old drug for hematological disorders
- (2017) Hai Zou et al. Oncotarget
- Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line
- (2017) Seyede Elmira Yazdi Rouholamini et al. Artificial Cells Nanomedicine and Biotechnology
- Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer
- (2017) Fatima Pashaei-Asl et al. Artificial Cells Nanomedicine and Biotechnology
- Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells
- (2017) Soumaye Amirsaadat et al. Artificial Cells Nanomedicine and Biotechnology
- HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies
- (2017) Haneen Amawi et al. Frontiers in Pharmacology
- Increased Loading, Efficacy and Sustained Release of Silibinin, a Poorly Soluble Drug Using Hydrophobically-Modified Chitosan Nanoparticles for Enhanced Delivery of Anticancer Drug Delivery Systems
- (2017) Cha Kuen et al. Nanomaterials
- Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro
- (2016) Nan Zheng et al. ACTA PHARMACOLOGICA SINICA
- ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells
- (2016) Nan Zheng et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Development of pH-sensitive self-nanoemulsifying drug delivery systems for acid-labile lipophilic drugs
- (2016) Tianjing Zhao et al. CHEMISTRY AND PHYSICS OF LIPIDS
- In vitro drug release characteristic and cytotoxic activity of silibinin-loaded single walled carbon nanotubes functionalized with biocompatible polymers
- (2016) Julia Meihua Tan et al. Chemistry Central Journal
- Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review
- (2016) Navaneethakrishnan Polachi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Silibinin derivatives as anti-prostate cancer agents: Synthesis and cell-based evaluations
- (2016) Bao Vue et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status
- (2016) Daiane Teixeira de Oliveira et al. JOURNAL OF BIOSCIENCES
- Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells
- (2016) Masoud Maleki Zadeh et al. Journal of Breast Cancer
- Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives
- (2016) Gaurav Kumar et al. LIFE SCIENCES
- PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications
- (2016) Cecilia C. Torres et al. Materials Science & Engineering C-Materials for Biological Applications
- Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- (2016) Gagan Deep et al. MOLECULAR CARCINOGENESIS
- A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma
- (2016) Ioannis Anestopoulos et al. MOLECULES
- Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy
- (2016) Ommoleila Molavi et al. PHARMACEUTICAL BIOLOGY
- Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
- (2016) Sepideh Elyasi et al. PHYTOTHERAPY RESEARCH
- Molecular targets of gambogic acid in cancer: recent trends and advancements
- (2016) Dharambir Kashyap et al. TUMOR BIOLOGY
- Inhibitory effects of silibinin on proliferation and lung metastasis of human high metastasis cell line of salivary gland adenoid cystic carcinoma via autophagy induction
- (2016) Canhua Jiang et al. OncoTargets and Therapy
- Silibinin: a potential old drug for cancer therapy
- (2016) Xing-Xing Zhu et al. Expert Review of Clinical Pharmacology
- Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo
- (2015) Mrinmay Chakrabarti et al. APOPTOSIS
- Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
- (2015) Sang-Hun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells
- (2015) Wan Feng et al. BIOMEDICINE & PHARMACOTHERAPY
- Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells
- (2015) Mrinmay Chakrabarti et al. BRAIN RESEARCH
- MicroRNA-7: a promising new target in cancer therapy
- (2015) Juanjuan Zhao et al. Cancer Cell International
- A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast Cancer
- (2015) M. Lazzeroni et al. Cancer Prevention Research
- Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma
- (2015) Jin Li et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Synthesis of New Silybin Derivatives and Evaluation of Their Antioxidant Properties
- (2015) Armando Zarrelli et al. HELVETICA CHIMICA ACTA
- Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma
- (2015) Feng Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach
- (2015) RakeshM Rawal et al. Journal of Cancer Research and Therapeutics
- ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells
- (2015) Nan Zheng et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects
- (2015) Hardeep Singh Tuli et al. LIFE SCIENCES
- Long non-coding RNA: A new paradigm for lung cancer
- (2015) Akanksha Khandelwal et al. MOLECULAR CARCINOGENESIS
- Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma
- (2015) ZHENKUN MA et al. ONCOLOGY REPORTS
- Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- (2015) KAI JIANG et al. ONCOLOGY REPORTS
- Isothiocyanates: a class of bioactive metabolites with chemopreventive potential
- (2015) Gaurav Kumar et al. TUMOR BIOLOGY
- Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas
- (2015) Yu-Chao Chang et al. Oncotarget
- Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- (2015) Surendra K. Shukla et al. Oncotarget
- Laser light triggered smart release of silibinin from a PEGylated–PLGA gold nanocomposite
- (2015) E. Fazio et al. Journal of Materials Chemistry B
- Silibinin Inhibits Proliferation, Induces Apoptosis and Causes Cell Cycle Arrest in Human Gastric Cancer MGC803 Cells Via STAT3 Pathway Inhibition
- (2014) Yi-Xin Wang et al. Asian Pacific Journal of Cancer Prevention
- Fabrication, characterization and bioevaluation of silibinin loaded chitosan nanoparticles
- (2014) Deep Pooja et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells
- (2014) L. Gándara et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Enhanced cytotoxicity and apoptosis-induced anticancer effect of silibinin-loaded nanoparticles in oral carcinoma (KB) cells
- (2014) M. Gohulkumar et al. Materials Science & Engineering C-Materials for Biological Applications
- Silibinin prevents prostate cancer cell-mediated differentiation of naïve fibroblasts into cancer-associated fibroblast phenotype by targeting TGF β2
- (2014) Harold J. Ting et al. MOLECULAR CARCINOGENESIS
- Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling
- (2014) Gagan Deep et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Chemistry of silybin
- (2014) D. Biedermann et al. NATURAL PRODUCT REPORTS
- Silibinin inhibits accumulation of myeloid-derived suppressor cells and tumor growth of murine breast cancer
- (2014) Parvin Forghani et al. Cancer Medicine
- Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer
- (2013) Harold Ting et al. AAPS Journal
- Energy deprivation by silibinin in colorectal cancer cells
- (2013) Komal Raina et al. Autophagy
- MiR-200, a new star miRNA in human cancer
- (2013) Xiangling Feng et al. CANCER LETTERS
- A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma
- (2013) Abby B. Siegel et al. INTEGRATIVE CANCER THERAPIES
- Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
- (2013) Antero Salminen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2013) José G. Napolitano et al. JOURNAL OF ORGANIC CHEMISTRY
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- (2013) Hanan S. Althagafy et al. JOURNAL OF ORGANIC CHEMISTRY
- Chemopreventive and Anti-Cancer Efficacy of Silibinin Against Growth and Progression of Lung Cancer
- (2013) Samiha Mateen et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Silybin-Mediated Inhibition of Notch Signaling Exerts Antitumor Activity in Human Hepatocellular Carcinoma Cells
- (2013) Song Zhang et al. PLoS One
- Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells
- (2013) HENRIETTE KAUNTZ et al. Oncology Letters
- Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
- (2013) Sílvia Cufí et al. Scientific Reports
- Silibinin – A Promising New Treatment for Cancer
- (2012) Catherine Wing Ying Cheung et al. Anti-Cancer Agents in Medicinal Chemistry
- The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells
- (2012) Henriette Kauntz et al. APOPTOSIS
- Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs
- (2012) Saakshi Jalali et al. Biology Direct
- THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY - A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL
- (2012) Ales Vidlar et al. BIOMEDICAL PAPERS-OLOMOUC
- In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
- (2012) Dhanya Nambiar et al. CANCER LETTERS
- Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells
- (2012) Samiha Mateen et al. Epigenetics
- P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells
- (2012) Simiao Fan et al. FREE RADICAL RESEARCH
- P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK
- (2012) Simiao Fan et al. FREE RADICAL RESEARCH
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- (2012) Chiu-Mei Lin et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- In Vivo Evaluation of Silybin Nanosuspensions Targeting Liver
- (2012) Yancai Wang et al. Journal of Biomedical Nanotechnology
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- (2012) Chandagirikoppal V. Kavitha et al. MOLECULAR CARCINOGENESIS
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- (2012) Yuanxin Zhang et al. PHYTOTHERAPY RESEARCH
- Silibinin Activated p53 and Induced Autophagic Death in Human Fibrosarcoma HT1080 Cells via Reactive Oxygen Species-p38 and c-Jun N-Terminal Kinase Pathways
- (2011) Wen-Jun Duan et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- In vitro antitumor activity of silybin nanosuspension in PC-3 cells
- (2011) Dandan Zheng et al. CANCER LETTERS
- Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells
- (2011) Y. Zhang et al. CELL BIOCHEMISTRY AND FUNCTION
- Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells
- (2011) Yuan-yuan Jiang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2011) Binbin Liu et al. FREE RADICAL RESEARCH
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- (2011) Yakun Ge et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2011) Wen-Jun Duan et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Silibinin Enhances Ultraviolet B-Induced Apoptosis in MCF-7 Human Breast Cancer Cells
- (2011) Eun-Mi Noh et al. Journal of Breast Cancer
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- (2011) J. Zeng et al. MOLECULAR CANCER THERAPEUTICS
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- (2011) Horng-Rong Chang et al. MOLECULAR CARCINOGENESIS
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- (2011) Komal Raina et al. MOLECULAR CARCINOGENESIS
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- (2011) Giuseppina Marrazzo et al. NEUROSCIENCE LETTERS
- Topical Use of a Silymarin-Based Preparation to Prevent Radiodermatitis
- (2011) Martina Becker-Schiebe et al. STRAHLENTHERAPIE UND ONKOLOGIE
- Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer
- (2010) Gagan Deep et al. CANCER AND METASTASIS REVIEWS
- Silibinin-Induced Apoptosis in MCF7 and T47D Human Breast Carcinoma Cells Involves Caspase-8 Activation and Mitochondrial Pathway
- (2010) Prabha Tiwari et al. CANCER INVESTIGATION
- Chemoprevention of Intestinal Tumorigenesis in APCmin/+ Mice by Silibinin
- (2010) S. Rajamanickam et al. CANCER RESEARCH
- Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies
- (2010) Lejiao Jia et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells
- (2010) Hong-Jun Wang et al. FREE RADICAL RESEARCH
- Silibinin Induced Autophagic and Apoptotic Cell Death in HT1080 Cells Through a Reactive Oxygen Species Pathway
- (2010) Wenjun Duan et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- In vitroandin vivoevaluation of silybin nanosuspensions for oral and intravenous delivery
- (2010) Yancai Wang et al. NANOTECHNOLOGY
- Silibinin Exerts Sustained Growth Suppressive Effect against Human Colon Carcinoma SW480 Xenograft by Targeting Multiple Signaling Molecules
- (2010) Balaiya Velmurugan et al. PHARMACEUTICAL RESEARCH
- A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL)
- (2009) Elena J. Ladas et al. CANCER
- Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C
- (2009) Roy L. Hawke et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
- (2009) Marco Trappoliere et al. JOURNAL OF HEPATOLOGY
- Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
- (2009) M. Kaur et al. MOLECULAR CANCER THERAPEUTICS
- Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model
- (2008) K. Raina et al. CANCER RESEARCH
- Silibinin Inhibits Colorectal Cancer Growth by Inhibiting Tumor Cell Proliferation and Angiogenesis
- (2008) R. P. Singh et al. CANCER RESEARCH
- Silibinin Inhibits Established Prostate Tumor Growth, Progression, Invasion, and Metastasis and Suppresses Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Transgenic Adenocarcinoma of the Mouse Prostate Model Mice
- (2008) R. P. Singh et al. CLINICAL CANCER RESEARCH
- Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity—role of individual hydroxyl groups
- (2008) Radek Gažák et al. FREE RADICAL BIOLOGY AND MEDICINE
- The potential of milk thistle (Silybum marianumL.), an Israeli native, as a source of edible sprouts rich in antioxidants
- (2008) Yiftach Vaknin et al. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
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