Review
Biochemistry & Molecular Biology
Andrey S. Drozdov, Petr I. Nikitin, Julian M. Rozenberg
Summary: This study explores the active targeting of nanoparticles towards tumors, analyzing factors influencing efficient targeting and therapy. It reveals that increased tumor accumulation of targeted nanoparticles coincides with decreased uptake by the spleen, with no correlation between changes in nanoparticle concentration in tumors versus other organs. Moreover, the study highlights the impact of targeting molecules and nanoparticle type on splenic and tumor accumulation, showing that combinatorial targeting of nanoparticle drugs leads to higher treatment efficiencies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Jing Lu, Long Xie, Anxin Wu, Xian Wang, Youdan Liang, Xiaolin Dai, Yi Cao, Xiaofang Li
Summary: Silybin-loaded zein-pullulan nanoparticles were prepared to improve the water solubility and chemical stability of silybin, a natural flavonoid used in the treatment of cirrhosis. The optimized nanoparticles showed uniform distribution, smooth spherical shape, and high encapsulation efficiency. In vitro experiments demonstrated sustained release of silybin and enhanced antioxidant capacity using this novel delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Yueyue Fan, Yuexin Cui, Wenyan Hao, Mengyu Chen, Qianqian Liu, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Shiyong Song, Yang Yang, Chunsheng Gao
Summary: Nanosuspensions, as a drug delivery system for insoluble drugs, can significantly improve the dissolution, bioavailability, and efficacy of such drugs. This study successfully developed a nanosuspension with tumor-targeting and blood-brain barrier penetration capabilities, which showed increased uptake by tumor cells and distribution in intracranial gliomas. The biomimetic nanosuspension demonstrated promising potential for tumor therapy with enhanced targeting abilities.
BIOACTIVE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Luca Casula, Chiara Sinico, Donatella Valenti, Elena Pini, Rosa Pireddu, Michele Schlich, Francesco Lai, Anna Maria Fadda
Summary: This study confirmed the ability of electronic nicotine delivery systems (ENDS) to deliver drug nanocrystals through aerosol production, suggesting their potential alternative use as medical devices for poorly soluble drugs delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Nancy M. Elbaz, Lee M. Tatham, Andrew Owen, Steve Rannard, Tom O. McDonald
Summary: Curcumin is widely used in nutraceutical products for its various biological activities, but its low solubility and stability limit its effectiveness. By formulating curcumin as a nanosuspension, its physical and chemical properties can be improved, offering new opportunities for oral dosing with better bioavailability and stability.
FOOD HYDROCOLLOIDS
(2021)
Article
Instruments & Instrumentation
Wen He, Junfeng Zhang, Jiale Ju, Yinghua Wu, Yuxi Zhang, Lin Zhan, Chenchen Li, Yanli Wang
Summary: We developed kaempferol nanosuspensions (KAE-NSps) using D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) as a stabilizing agent, which significantly improved the solubility and antitumor effects of kaempferol. The optimized TPGS-KAE-NSps had a particle size of 186.6 +/- 2.6 nm and showed favorable stability, biocompatibility, sustained release effect, and enhanced cytotoxicity in vitro. In vivo studies demonstrated that TPGS-KAE-NSps had prolonged duration of action, improved bioavailability, stronger inhibition of tumor growth, and no obvious toxicity. Overall, TPGS-KAE-NSps are a promising nanodrug delivery system for kaempferol with potential clinical applications as an antitumor drug.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Jun Wang, Jing Liu, Zhongxing Yang
Summary: The article discusses the potential of hypoxia as a therapeutic target and the use of peptides for targeting hypoxic diseases. It highlights three main strategies for targeting hypoxia using peptide-based nanomaterials and emphasizes the advantages of peptides in treatment and diagnosis processes.
NANOSCALE ADVANCES
(2021)
Article
Materials Science, Biomaterials
Adam Leach, Marie Finnegan, Mariana S. Machado, Laura Ferguson, John Steven, Peter Smyth, Andrew Porter, Caroline Barelle, Efrosyni Themistou, Christopher J. Scott
Summary: This study focuses on the development of actively targeted drug loaded nanoparticles for cancer and other diseases. A new polymer was synthesized and modified to allow the attachment of targeting ligands. The resulting nanoparticles showed specific affinity to their target antigen and have potential for therapeutic development.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Mukaddes Izci, Christy Maksoudian, Filipa Goncalves, Irati Perez Gilabert, Carla Rios Luci, Eduardo Bolea-Fernandez, Frank Vanhaecke, Bella B. Manshian, Stefaan J. Soenen
Summary: The authors investigated the ability to improve nanoparticle delivery to solid tumors through an in-depth mechanistic study on the use of ciRGD peptide co-administration. The results showed that ciRGD can improve nanoparticle delivery to the tumor itself, as well as to tumor cells specifically, better than vessel normalization strategies. The effectiveness of ciRGD co-administration depends on tumor perfusion, hypoxia, neutrophil levels, and vessel permeability.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Mukaddes Izci, Christy Maksoudian, Filipa Goncalves, Lucia Aversa, Robbe Salembier, Ara Sargsian, Irati Perez Gilabert, Tianjiao Chu, Carla Rios Luci, Eduardo Bolea-Fernandez, David Nittner, Frank Vanhaecke, Bella B. Manshian, Stefaan J. Soenen
Summary: In this study, the delivery of nanoparticles to solid tumors was investigated using gold nanoparticles of different sizes as model systems. The results showed that multiple parameters, including size, influenced the delivery of nanoparticles, with most nanoparticles being sequestered by tumor-associated cells rather than reaching tumor cells. It was also found that the maturity level of tumor-associated blood vessels and the presence of specialized endothelial cells played important roles in nanoparticle delivery. This study identified parameters that can be used to determine the suitability of nanoparticle delivery and provided insights for personalized nanoparticle delivery approaches.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Plant Sciences
Xiao-lu Wang, Fo-lan Lin, Wei Xu, Chen Wang, Qi-qi Wang, Ren-Wang Jiang
Summary: Silybin, a component of Silybum marianum, has been found to have a therapeutic effect on many diseases. This study aimed to investigate the protective effect of silybin on cisplatin-induced neurotoxicity and compare the difference between the two stereoisomers, silybin A and silybin B.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yueyue Fan, Wenyan Hao, Yuexin Cui, Mengyu Chen, Xiaoyang Chu, Yang Yang, Yuli Wang, Chunsheng Gao
Summary: A biomimetic nanosuspension has been developed to effectively cross the blood-brain barrier and target tumors by camouflaging the cancer cell membrane on the drug nanosuspension without any ligand modification, leading to stable and efficient results.
Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
