Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP

Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years

(2017) Alessandro Federico et al.   MOLECULES

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

(2017) Joachim Bischof et al.   TUMOR BIOLOGY

Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway

(2016) NAN FENG et al.   Molecular Medicine Reports

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009–2013

(2016) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’

(2016) Soha Jawhari et al.   Cell Death & Disease

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells

(2016) Francesca Angeletti et al.   Frontiers in Molecular Neuroscience

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells

(2016) Eun Jung Park et al.   Scientific Reports

Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo

(2015) Mrinmay Chakrabarti et al.   APOPTOSIS

Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells

(2015) Mrinmay Chakrabarti et al.   BRAIN RESEARCH

Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma

(2015) Feng Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma

(2015) ZHENKUN MA et al.   ONCOLOGY REPORTS

Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals

(2015) Sushil Kumar et al.   Oncotarget

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis

(2014) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy as a pro-death pathway

(2014) Donna Denton et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

(2014) Ning Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis

(2013) Weiwei Liu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Chemopreventive and Anti-Cancer Efficacy of Silibinin Against Growth and Progression of Lung Cancer

(2013) Samiha Mateen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway

(2012) Dalin He   ONCOLOGY REPORTS

Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells

(2011) Yuan-yuan Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silibinin mode(s) of action against hepatitis C virus: A controversy yet to be resolved

(2011) Harel Dahari et al.   HEPATOLOGY

Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria

(2011) J. Zeng et al.   MOLECULAR CANCER THERAPEUTICS

Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel

(2011) Horng-Rong Chang et al.   MOLECULAR CARCINOGENESIS

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9

(2010) Majid Momeny et al.   ANTI-CANCER DRUGS

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells

(2010) Hong-Jun Wang et al.   FREE RADICAL RESEARCH

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression

(2009) Kai-jie Wu et al.   ACTA PHARMACOLOGICA SINICA

Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy

(2009) Lester M. Davids et al.   CELL BIOLOGY INTERNATIONAL

The Protective Effect of Silibinin Against Mitomycin C–Induced Intrinsic Apoptosis in Human Melanoma A375-S2 Cells

(2009) Yuan-yuan Jiang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR–ERK activation in renal cell carcinoma

(2008) Lei Li et al.   CANCER LETTERS