Metabolism, Transport and Drug–Drug Interactions of Silymarin

Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review

(2019) Vahid Soleimani et al.   PHYTOTHERAPY RESEARCH

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat

(2018) Wei-Lun Hung et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies

(2018) Zhong-Wen Yuan et al.   PHARMACOLOGICAL RESEARCH

Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2

(2018) Xiaoli Bi et al.   PHYTOMEDICINE

Milk thistle (Silybum marianum ): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

(2018) Ludovico Abenavoli et al.   PHYTOTHERAPY RESEARCH

Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator

(2018) Zohreh Jahanafrooz et al.   LIFE SCIENCES

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

(2018) Peng Xu et al.   Frontiers in Pharmacology

Piperine-mediated drug interactions and formulation strategy for piperine: recent advances and future perspectives

(2017) Sang Hoon Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

Role of UDP-Glucuronosyltransferase 1A1 in the Metabolism and Pharmacokinetics of Silymarin Flavonolignans in Patients with HCV and NAFLD

(2017) Ying Xie et al.   MOLECULES

Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years

(2017) Alessandro Federico et al.   MOLECULES

Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism

(2017) Michal Bijak   MOLECULES

Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo

(2015) Mrinmay Chakrabarti et al.   APOPTOSIS

Biotransformation of Silybin and its Congeners

(2013) Vladimír Kren et al.   CURRENT DRUG METABOLISM

Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits

(2013) Swathi Voruganti et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Effect of Addition of Silymarin to Renin-Angiotensin System Inhibitors on Proteinuria in Type 2 Diabetic Patients With Overt Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Mohammad Kazem Fallahzadeh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Milk Thistle on the Pharmacokinetics of Darunavir-Ritonavir in HIV-Infected Patients

(2012) José Moltó et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Study on the Influence of Silymarin Pretreatment on Metabolism and Disposition of Metronidazole

(2012) Kandhagatla Rajnarayana et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Effect of Silymarin (Milk Thistle) on Liver Disease in Patients With Chronic Hepatitis C Unsuccessfully Treated With Interferon Therapy

(2012) Michael W. Fried   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacokinetic Herb-Drug Interactions (Part 2): Drug Interactions Involving Popular Botanical Dietary Supplements and Their Clinical Relevance

(2012) Bill Gurley et al.   PLANTA MEDICA

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases

(2011) Petra Jančová et al.   XENOBIOTICA

Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers

(2009) Yang Han et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Two Flavonolignans from Milk Thistle (Silybum marianum) Inhibit CYP2C9-Mediated Warfarin Metabolism at Clinically Achievable Concentrations

(2009) S. J. Brantley et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers

(2009) Y. Han et al.   XENOBIOTICA

Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model

(2008) K. Raina et al.   CANCER RESEARCH

The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity

(2008) S. J. Schrieber et al.   DRUG METABOLISM AND DISPOSITION

Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)

(2008) S. R. Miranda et al.   DRUG METABOLISM AND DISPOSITION

Drug–drug interactions of silymarin on the perspective of pharmacokinetics

(2008) Jhy-Wen Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, andEchinacea

(2008) Bill J. Gurley et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effect of Silymarin Supplement on the Pharmacokinetics of Rosuvastatin

(2008) Jian Wei Deng et al.   PHARMACEUTICAL RESEARCH