Article
Chemistry, Multidisciplinary
Yubin Ma, Yiyang Guo, Shan Liu, Yu Hu, Cheng Yang, Gang Cheng, Changying Xue, Yi Y. Zuo, Bingbing Sun
Summary: Zwitterionic polymers with superior antifouling properties are promising trans-mucus nanocarriers. The effect of pH microenvironment on the trans-mucus fate of pH-sensitive zwitterionic polymers is unclear. This study prepared zwitterionic polydopamine-modified silica nanoparticles (SiNPs-PDA) and found that the diffusion of SiNPs-PDA in mucus with a pH value of 5.6 was 3 times faster than in mucus with pH values 3.0 or 7.0. The pH-mediated mucus penetration behavior of SiNPs-PDA was mediated by hydrophobic and electrostatic interactions and hydrogen bonding between mucin and the particles.
Article
Engineering, Environmental
Ying Liu, Junyi Shen, Jiangpei Shi, Xiaoyan Gu, Haizhen Chen, Xiaoyu Wang, Lixin Wang, Ping Wang, Xuefeng Hou, Yuanzhi He, Chunyun Zhu, Zhi Wang, Teng Guo, Shengrong Guo, Nianping Feng
Summary: Oral delivery of therapeutic agents faces challenges in nanocarrier transfer in the gastrointestinal tract, overcoming physical stability, mucus penetration, and cellular uptake. Developing functional nanocarriers coated with microbial-derived sophorolipid assemblies shows promise in improving bioavailability and inhibiting breast cancer metastasis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jianbo Li, Hong Qiang, Weijing Yang, Yaru Xu, Tiange Feng, Huijie Cai, Shuaishuai Wang, Zhilei Liu, Zhenzhong Zhang, Jinjie Zhang
Summary: This study presents a novel nanoparticle platform for oral drug delivery based on adaptation to the intestinal microenvironment, demonstrating efficient drug protection and rapid mucus penetration at the jejunal epithelial surface. The platform showed significant reductions in blood glucose levels after intrajejunal administration in both normal and diabetic rats, highlighting its potential for controlled drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yiyang Guo, Yubin Ma, Xin Chen, Min Li, Xuehu Ma, Gang Cheng, Changying Xue, Yi Y. Zuo, Bingbing Sun
Summary: The penetration behavior of nanoparticles in mucous is influenced by the physicochemical properties of the particles and the mucus microenvironment. In this study, the authors prepared a library of silica nanoparticles with different surface modifications and studied their mucus penetration behavior. They found that particle surface properties, such as PEGylation and amine/carboxyl groups, affected the immobilization and movement of the nanoparticles in mucus. The study provides insights for designing efficient transmucosal nanocarriers for pulmonary diseases.
Review
Chemistry, Multidisciplinary
Taoxing Peng, Xinyue Shao, Li Long, Han Liu, Wenqin Song, Jiazhen Hou, Haijun Zhong, Yang Ding, Yongzhuo Huang
Summary: Hypoglycemic peptides have clinical benefits for diabetics, but their oral bioavailability is poor. Nano drug delivery systems offer a promising solution. This review introduces the therapeutic application of hypoglycemic peptides and analyzes the barriers to oral NDDS delivery efficiency. A six-step delivery cascade guideline is proposed and recent strategies to overcome these barriers are summarized.
Article
Chemistry, Multidisciplinary
Yanqi Qiao, Mengfan Han, Hongli Fu, Yaying Xu, Yueping Bai, Shuo Wang, Jie Yu, Changjun Men, Yongmei Yin, Xiujie Zhao, Rimo Xi, Meng Meng
Summary: This study engineered a phototherapeutic nanomedicine that can penetrate gastric mucus and target MDR H. pylori infection. In in vivo experiments, the nanomedicine showed impressive eradication of H. pylori.
Article
Chemistry, Multidisciplinary
Yuxin Wang, Lin Zhao, Yibo Dai, Miao Xu, Ruilin Zhou, Bingxin Zhou, Kaijun Gou, Rui Zeng, Lu Xu, Heran Li
Summary: This study demonstrates the importance of chirality in the oral adsorption efficiency of nanocarriers. The l-CMSNs, modified with l-tartaric acid, outperformed other chiral and achiral counterparts in sequential processes including mucus permeation, mucosa bio-adhesion, cellular uptake, intestinal transport, and gastrointestinal tract retention. Furthermore, l-CMSN showed stable absorption into the blood, improved intestinal transport for the loaded drug, and enhanced bioavailability and antitumor effect.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yingui Cao, Shengsheng Liu, Ya Ma, Lingli Ma, Menghang Zu, Jianfeng Sun, Fangyin Dai, Lian Duan, Bo Xiao
Summary: This study developed mesoporous manganese oxide-based nanomotors driven by hydrogen peroxide/ultrasound to improve the penetration of oral nanomedicines into colon tumors and activate anti-tumor immunity. The nanomotors demonstrated enhanced locomotory activities and tumor-targeting capacities, and the excess hydrogen peroxide in the tumor microenvironment could be decomposed into oxygen and hydroxyl radicals, leading to effective treatment of colon cancer through chemodynamic therapy and sonodynamic therapy.
Article
Chemistry, Multidisciplinary
Yuansong Wei, Xudong Li, Juanhui Lin, Yang Zhou, Jiandong Yang, Mengying Hou, Fan Wu, Jing Yan, Chenglong Ge, Duanmin Hu, Lichen Yin
Summary: A small-sized fluorinated nanocapsule (F-NCs) is developed for efficient oral delivery of siRNA for anti-inflammation treatment. The F-NCs possess a stable structure with excellent mucus penetration and intestinal transport capabilities. The released siRNA can effectively silence the target gene and exhibit pronounced anti-inflammatory efficacy.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Cheng Xu, Haiting Xu, Zhenhua Zhu, Xiaoxiao Shi, Bo Xiao
Summary: Oral administration is the most common route for treating colonic diseases. However, the colonic mucus acts as a barrier that limits the effectiveness of orally administered drugs. Mucus-penetrating nanotherapeutics have been developed to overcome this barrier and improve treatment outcomes for colonic diseases.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Polymer Science
Syed Sarim Imam, Sadaf Jamal Gilani, May Nasser Bin Jumah, Md Rizwanullah, Ameeduzzafar Zafar, Mohammed Muqtader Ahmed, Sultan Alshehri
Summary: This study developed THQ-loaded lipid-polymer hybrid nanoparticles (THQ-LPHNPs) based on chitosan, which showed enhanced oral bioavailability for THQ. The optimized THQ-LPHNPs exhibited ideal properties for oral administration, including a small particle size, high entrapment efficiency, and good stability. They also demonstrated excellent mucin binding efficiency and enhanced anti-breast cancer activity. Furthermore, the optimized THQ-LPHNPs showed significantly increased permeation and bioavailability compared to conventional THQ suspension.
Article
Biochemistry & Molecular Biology
Mahboubeh Ebrahimian, Fatemeh Mahvelati, Bizhan Malaekeh-Nikouei, Ezzat Hashemi, Fatemeh Oroojalian, Maryam Hashemi
Summary: A lipopolymeric nanoparticle containing bromelain was developed to enhance its stability and oral delivery efficiency. The results showed that this nanoparticle had higher encapsulation efficiency and released more bromelain in different pH environments. It also demonstrated higher absorption through Caco-2 cells compared to other nanoparticles.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Hao, Shu Bai, Linling Yu, Yan Sun
Summary: In this study, a magnetically driven, mucus-inert Janus-type nanovehicle was fabricated, which effectively improved the diffusion and endocytosis of the nanovehicles in mucus.
Article
Pharmacology & Pharmacy
Muhammad Asghar Khan, Shahzeb Khan, Mohsin Kazi, Sultan M. Alshehri, Muhammad Shahid, Shafi Ullah Khan, Zahid Hussain, Muhammad Sohail, Muhammad Shafique, Hajra Afeera Hamid, Mahwish Kamran, Abdelbary Elhissi, Muhammad Wasim, Hnin Ei Thu
Summary: Norfloxacin-loaded Lipid-Polymer Hybrid Nanoparticles (LPHNs) were successfully prepared with optimized process conditions, demonstrating improved bioavailability and stability compared to commercial products in both in vitro and in vivo studies. This suggests that LPHNs are a promising system for the delivery of Norfloxacin and other antibiotics and hydrophobic drugs.
Article
Nanoscience & Nanotechnology
Rui Ni, Lele Huang, Zhen Li, Wenli Zhang, Yajie Wang, Yan Shen, Jianxin Wang, Weigen Lu
Summary: The study developed ROS-responsive transformable LPNs, demonstrating their enhanced tumor penetration and antitumor efficacy in 3D tumor spheroids and in vivo models.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Medicinal
Tong Wu, Chunyun Zhu, Xiang Wang, Qingyue Kong, Teng Guo, Zehui He, Yuanzhi He, Shuyao Ruan, Hang Ruan, Lixia Pei, Yongtai Zhang, Nianping Feng
Summary: Cholesterol- and phospholipid-free multilamellar niosomes (MLNs) were designed and evaluated for transdermal drug delivery. The optimized MLNs exhibited sustained drug release, improved permeation of the stratum corneum, and deep penetration into the skin through hair follicles. The study demonstrates the potential of MLNs as a promising alternative for topical and transdermal drug delivery.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Environmental
Ying Liu, Junyi Shen, Jiangpei Shi, Xiaoyan Gu, Haizhen Chen, Xiaoyu Wang, Lixin Wang, Ping Wang, Xuefeng Hou, Yuanzhi He, Chunyun Zhu, Zhi Wang, Teng Guo, Shengrong Guo, Nianping Feng
Summary: Oral delivery of therapeutic agents faces challenges in nanocarrier transfer in the gastrointestinal tract, overcoming physical stability, mucus penetration, and cellular uptake. Developing functional nanocarriers coated with microbial-derived sophorolipid assemblies shows promise in improving bioavailability and inhibiting breast cancer metastasis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Tianyuan Ci, Wentao Zhang, Yingyu Qiao, Huangjuan Li, Jing Zang, Hongjun Li, Nianping Feng, Zhen Gu
Summary: This review discusses the current state and advances in anti-leukemia drugs and therapies, with a focus on the development of drug delivery systems for leukemia treatment. These delivery systems improve the pharmacokinetics of drugs in vivo, targeting specific cells or tumor microenvironment and reversing drug resistance, leading to enhanced tumor elimination and reduced adverse effects.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Engineering, Biomedical
Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang
Summary: In this study, a metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform was designed and fabricated for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer. The nanoplatform, created through a solvothermal synthesis process, demonstrated the ability to deplete glutathione, increase reactive oxidative species oxidative stress, and exhibit remarkable anticancer properties. This research provides a new strategy for overcoming multidrug resistance.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Environmental
Hongmei Hu, Hang Ruan, Shuyao Ruan, Lixia Pei, Qian Jing, Tong Wu, Xiaolin Hou, Hao Xu, Youjie Wang, Nianping Feng, Yongtai Zhang
Summary: By designing PEGylated star-shaped PLGA nanoparticles with immune stealth and acid-responsive properties, the drug-loading ability and release efficiency of tetrandrine (Tet) were significantly improved. Furthermore, the integration of these nanoparticles into dissolving microneedles resulted in enhanced transdermal delivery and potential therapeutic efficacy for anti-inflammation treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, Research & Experimental
Yanyan Li, Shuyao Ruan, Jingwen Guo, Zehui He, Qing Xia, Tong Wu, Zhi Wang, Zhe Li, Hongmei Hu, Qian Jing, Xuefeng Hou, Yuanzhi He, Beibei Zhang, Nianping Feng, Yongtai Zhang
Summary: By constructing a composite nanocrown structure, the nanocarrier with cancer cell membrane-derived nanovesicles shows improved targeting capacity and drug delivery capability for cancer therapy. The biomimetic nanocrowns exhibit superior targeting ability and anticancer effects compared to hyaluronic acid modification.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Shuwen Ma, Jiaqi Li, Lixia Pei, Nianping Feng, Yongtai Zhang
Summary: Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and can be used as a substitute for blood in drug analysis. However, current ISF extraction techniques are bulky, time-consuming, and complicated. Microneedles have been widely used for transdermal drug delivery and can be successfully employed for ISF extraction, facilitating subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, and wearable devices with monitoring and delivery functions allow real-time dose modification. This review discusses the progress, future opportunities, and challenges of drug analysis based on microneedle-assisted ISF extraction.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Wansi Li, Yongtai Zhang, Panwen Huang, Ying Liu, Yongjia Zhang, Zhi Wang, Nianping Feng
Summary: The use of the liquisolid compression technique in preparing mini-tablets containing supercritical fluid extracts of frankincense and myrrh (SFE-FM) can improve the oral bioavailability of their active compounds. Various drug-loaded liquisolid formulations were prepared and evaluated, showing superior release of active compounds compared to traditional mini-tablets.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Xiaolin Hou, Meng Long, Nianping Feng, Yongtai Zhang
Summary: In this study, cinnamon oil was encapsulated in nanocapsules and incorporated into microneedles to create a new transdermal drug delivery system. The system showed improved transdermal flux and alleviated symptoms of primary dysmenorrhea in rats.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Xiang Wang, Xuefeng Hou, Yihan Wu, Jingwen Guo, Haichuan Tai, Yongtai Zhang, Nianping Feng
Summary: In this study, a new preparation of CHR-loaded liposomal gel (CHR-LipGel) with good physicochemical stability and efficient antiphotoaging properties was described. The CHR-loaded liposomes were hybridized with D-a-tocopherol polyethylene glycol succinate and Poloxamer 188, and dispersed in sodium hyaluronate-formed hydrogel to obtain CHR-Lip-Gel. The CHR-Lip-Gel significantly increased skin permeability and skin retention of chrysin, and showed superior cellular uptake and anti-photoaging effects compared to free CHR. The newly developed CHR-Lip-Gel is a superior anti-photoaging system. Rating: 8/10.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Xiaolin Hou, Jiaqi Li, Yongyu Hong, Hang Ruan, Meng Long, Nianping Feng, Yongtai Zhang
Summary: Transdermal drug delivery (TDD) is a key approach for treating diseases and improving patient compliance. Microneedling is a relatively simple and efficient means of drug delivery, and is often used to improve the efficiency of TDD.
Article
Pharmacology & Pharmacy
Hongyu Zhang, Jingwen Guo, Zhi Wang, Na Wang, Nianping Feng, Yongtai Zhang
Summary: This study aimed to compare the performance differences of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) in transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol((R)) 888 ATO, ethyl oleate, Cremophor((R)) EL, and Transcutol(R) P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the Millicell (TM) membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells.
ACTA PHARMACEUTICA
(2023)
Article
Biophysics
Huining Ding, Qing Xia, Jiaqi Shen, Chunyun Zhu, Yongtai Zhang, Nianping Feng
Summary: The clinical translational success of nanomedicine and immunotherapy has demonstrated the immense potential of nanotechnology and immunization. Combining immunotherapy with nanomedicine effectively overcomes the limitations of single therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Jing Zang, Jinniu Zhang, Yijun Mei, Yaoxuan Xiong, Tianyuan Ci, Nianping Feng
Summary: Immunogenic dead cells, engineered through the sequential treatment of live tumor cells with UV irradiation and cryo-shocking, can serve as a lung-targeting vehicle and tumor vaccine for chemoimmunotherapy. The drug-loaded dead cells can be trapped in the pulmonary capillaries and enhance drug accumulation in local tissues, while also eliciting antitumor immune responses. In a lung tumor-bearing mice model, this system achieved synergistic antitumor efficacy and prolonged survival.
BIOMATERIALS SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Chunyun Zhu, Yongtai Zhang, Tong Wu, Zehui He, Teng Guo, Nianping Feng
Summary: In this study, glycerosomes were used as a transdermal vehicle to enhance the delivery of triptolide. The formulation of glycerosomes was optimized and showed good stability and high entrapment efficiency. Glycerosomes significantly increased the transdermal delivery of triptolide compared to conventional liposomes. Glycerosomes have the potential to be used as an alternative to oral triptolide administration.
ACTA PHARMACEUTICA
(2022)