Chemistry of silybin

cis–transIsomerization of silybins A and B

(2014) Michaela Novotná et al.   Beilstein Journal of Organic Chemistry

Flavonolignans from Aspergillus iizukae, a Fungal Endophyte of Milk Thistle (Silybum marianum)

(2014) Tamam El-Elimat et al.   JOURNAL OF NATURAL PRODUCTS

Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers

(2014) Eva Vavříková et al.   MOLECULES

Identification of 23-(S)-2-Amino-3-Phenylpropanoyl-Silybin as an Antiviral Agent for Influenza A Virus InfectionIn VitroandIn Vivo

(2013) Jian-Ping Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver

(2013) Kateřina Purchartová et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Media Effects on the Mechanism of Antioxidant Action of Silybin and 2,3-Dehydrosilybin: Role of the Enol Group

(2013) Ewelina van Wenum et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Study of the Biomimetic Synthesis of Flavonolignan Diastereoisomers in Milk Thistle

(2013) Hanan S. Althagafy et al.   JOURNAL OF ORGANIC CHEMISTRY

Anti-Cancer Efficacy of Silybin Derivatives - A Structure-Activity Relationship

(2013) Chapla Agarwal et al.   PLoS One

Microwave-assisted oxidation of silibinin: a simple and preparative method for the synthesis of improved radical scavengers

(2013) Giovanni Di Fabio et al.   TETRAHEDRON LETTERS

Enhanced bioactivity of silybin B methylation products

(2012) Arlene A. Sy-Cordero et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preparation of silybin and isosilybin sulfates by sulfotransferase from Desulfitobacterium hafniense

(2012) Petr Marhol et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The basic antioxidant structure for flavonoid derivatives

(2012) Anna P. S. Mendes et al.   JOURNAL OF MOLECULAR MODELING

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

(2012) Radek Gažák et al.   TETRAHEDRON LETTERS

New C-23 modified of silybin and 2,3-dehydrosilybin: Synthesis and preliminary evaluation of antioxidant properties

(2011) Armando Zarrelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Antiangiogenic Activity of New Silybin Galloyl Esters

(2011) Radek Gažák et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regioselective alcoholysis of silybin A and B acetates with lipases

(2011) Kateřina Purchartová et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The Thermal and Enzymatic Taxifolin–Alphitonin Rearrangement

(2011) Paul W. Elsinghorst et al.   JOURNAL OF NATURAL PRODUCTS

Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids

(2011) Eleni Theodosiou et al.   New Biotechnology

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases

(2011) Petra Jančová et al.   XENOBIOTICA

Enzymatic Kinetic Resolution of Silybin Diastereoisomers⊥

(2010) Daniela Monti et al.   JOURNAL OF NATURAL PRODUCTS

Large-scale separation of silybin diastereoisomers using lipases

(2010) Radek Gažák et al.   PROCESS BIOCHEMISTRY

Enzymatic transformation of flavonoids and terpenoids: Structural and functional diversity of the novel derivatives

(2010) Epameinondas Xanthakis et al.   PURE AND APPLIED CHEMISTRY

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

(2009) Eleni Theodosiou et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties

(2009) Feng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antioxidant and antiviral activities of silybin fatty acid conjugates

(2009) Radek Gažák et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemoenzymatic preparative separation of silybins A and B

(2009) Vladimír Křen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity—role of individual hydroxyl groups

(2008) Radek Gažák et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

(2008) Patrick Trouillas et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography–tandem mass spectrometry

(2007) Wei Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Laccase-mediated dimerization of the flavonolignan silybin

(2007) Radek Gažák et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC