Toxoplasma gondii manipulates host cell signaling pathways via its secreted effector molecules

Toxoplasma GRA 15 limits parasite growth in IFN γ‐activated fibroblasts through TRAF ubiquitin ligases

(2020) Debanjan Mukhopadhyay et al.   EMBO JOURNAL

Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11

(2020) Debanjan Mukhopadhyay et al.   PLoS Pathogens

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

(2020) Yifan Wang et al.   Annual Review of Microbiology

Toxoplasma gondii Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway

(2020) Fumiaki Ihara et al.   Frontiers in Immunology

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

(2019) Mateo Murillo-León et al.   Nature Communications

Defining host–pathogen interactions employing an artificial intelligence workflow

(2019) Daniel Fisch et al.   eLife

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors

(2019) Lamba Omar Sangaré et al.   mBio

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase

(2019) Michael W. Panas et al.   mSphere

The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING

(2019) Peiyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii Intravacuolar-Network-Associated Dense Granule Proteins Regulate Maturation of the Cyst Matrix and Cyst Wall

(2019) Rebekah B. Guevara et al.   mSphere

Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection

(2019) Miwa Sasai et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

(2018) Hironori Bando et al.   Frontiers in Immunology

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

(2018) Hironori Bando et al.   mBio

Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα

(2017) Hyun-Jung Koh et al.   PLoS Pathogens

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

(2016) Elisabeth Kravets et al.   eLife

TheToxoplasma gondiirhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7

(2015) Thomas Hermanns et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity

(2015) Chul-Su Yang et al.   INFECTION AND IMMUNITY

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

(2015) Arun K. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men

(2014) Ricardo T. Gazzinelli et al.   Cell Host & Microbe

TheToxoplasmaPseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPases

(2014) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondiiVirulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation

(2014) Jian Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Development of an Immunochromatographic Assay Based on Dense Granule Protein 7 for Serological Detection of Toxoplasma gondii Infection

(2013) Mohamad Alaa Terkawi et al.   Clinical and Vaccine Immunology

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

(2013) Kirk D. C. Jensen et al.   INFECTION AND IMMUNITY

Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication

(2013) Wendy Niedelman et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

(2013) Jingtao Lilue et al.   eLife

Induction of Protective Immune Responses by a Multiantigenic DNA Vaccine Encoding GRA7 and ROP1 of Toxoplasma gondii

(2012) Juan-Hua Quan et al.   Clinical and Vaccine Immunology

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

(2012) Michael S. Behnke et al.   PLoS Pathogens

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

(2011) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma gondii effectors are master regulators of the inflammatory response

(2011) Mariane B. Melo et al.   TRENDS IN PARASITOLOGY

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virulent Toxoplasma gondii Evade Immunity-Related GTPase-Mediated Parasite Vacuole Disruption within Primed Macrophages

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL

Intervacuolar Transport and Unique Topology of GRA14, a Novel Dense Granule Protein in Toxoplasma gondii

(2008) M. E. Rome et al.   INFECTION AND IMMUNITY

The Toxoplasma gondii Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4

(2008) J. D. Dunn et al.   INFECTION AND IMMUNITY

The History ofToxoplasma gondii—The First 100 Years

(2008) JITENDER P. DUBEY   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Apicomplexa in Mammalian Cells: Trafficking to the Parasitophorous Vacuole

(2008) Marie-France Cesbron-Delauw et al.   TRAFFIC