Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes duringToxoplasma gondiiInfection

(2017) Lanny Gov et al.   JOURNAL OF IMMUNOLOGY

The human immune response to Toxoplasma: Autophagy versus cell death

(2017) Shruthi Krishnamurthy et al.   PLoS Pathogens

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Mouse and Human Autophagy Proteins in IFN- -Induced Cell-Autonomous Responses against Toxoplasma gondii

(2014) J. Ohshima et al.   JOURNAL OF IMMUNOLOGY

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Development of an Immunochromatographic Assay Based on Dense Granule Protein 7 for Serological Detection of Toxoplasma gondii Infection

(2013) Mohamad Alaa Terkawi et al.   Clinical and Vaccine Immunology

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

(2013) Emily E. Rosowski et al.   INFECTION AND IMMUNITY

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

(2013) Kirk D. C. Jensen et al.   INFECTION AND IMMUNITY

Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication

(2013) Wendy Niedelman et al.   INFECTION AND IMMUNITY

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15

(2013) L. Gov et al.   mBio

Inhibition of increased indoleamine 2,3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection

(2012) Yuki Murakami et al.   CYTOKINE

Ranking the Disease Burden of 14 Pathogens in Food Sources in the United States Using Attribution Data from Outbreak Investigations and Expert Elicitation

(2012) MICHAEL B. BATZ et al.   JOURNAL OF FOOD PROTECTION

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

Toxoplasma gondii Clonal Strains All Inhibit STAT1 Transcriptional Activity but Polymorphic Effectors Differentially Modulate IFNγ Induced Gene Expression and STAT1 Phosphorylation

(2012) Emily E. Rosowski et al.   PLoS One

Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling

(2011) Timothy B. Chaston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection

(2011) Senad Divanovic et al.   JOURNAL OF INFECTIOUS DISEASES

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

Toxoplasma gondii: 25 years and 25 major advances for the field

(2009) John C. Boothroyd   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Virulent Toxoplasma gondii Evade Immunity-Related GTPase-Mediated Parasite Vacuole Disruption within Primed Macrophages

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Genotype of 88Toxoplasma gondiiIsolates Associated with Toxoplasmosis in Immunocompromised Patients and Correlation with Clinical Findings

(2009) Daniel Ajzenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical Practice: Management ofToxoplasma gondiiInfection during Pregnancy

(2008) Jose G. Montoya et al.   CLINICAL INFECTIOUS DISEASES