Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

(2016) Alimuddin Zumla et al.   BMC Medicine

Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers

(2016) Robert S Wallis et al.   LANCET INFECTIOUS DISEASES

Immunodiagnosis and molecular validation of Toxoplasma gondii-recombinant dense granular (GRA) 7 protein for the detection of toxoplasmosis in patients with cancer

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PLD1 activation mediates Amb a 1-induced Th2-associated cytokine expression via the JNK/ATF-2 pathway in BEAS-2B cells

(2015) Joo-Hwa Kim et al.   CELLULAR IMMUNOLOGY

TheToxoplasma gondiirhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7

(2015) Thomas Hermanns et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity

(2015) Chul-Su Yang et al.   INFECTION AND IMMUNITY

Towards host-directed therapies for tuberculosis

(2015) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice

(2015) Angelika Wagner et al.   PLoS One

Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review

(2015) Dilara Kiran et al.   Seminars in Immunopathology

Toxoplasma gondii: Vaccination with a DNA vaccine encoding T- and B-cell epitopes of SAG1, GRA2, GRA7 and ROP16 elicits protection against acute toxoplasmosis in mice

(2015) Aiping Cao et al.   VACCINE

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

(2015) Rajshekhar Y. Gaji et al.   PLoS Pathogens

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

A Highly Conserved Toxo1 Haplotype Directs Resistance to Toxoplasmosis and Its Associated Caspase-1 Dependent Killing of Parasite and Host Macrophage

(2014) Pierre Cavailles et al.   PLoS Pathogens

A Host GPCR Signaling Network Required for the Cytolysis of Infected Cells Facilitates Release of Apicomplexan Parasites

(2013) Melanie G. Millholland et al.   Cell Host & Microbe

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

IL-1  Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation

(2013) P. Jayaraman et al.   JOURNAL OF IMMUNOLOGY

Mapping and analysis of phosphorylation sites: a quick guide for cell biologists

(2013) Noah Dephoure et al.   MOLECULAR BIOLOGY OF THE CELL

Vitamin D Induces Interleukin-1β Expression: Paracrine Macrophage Epithelial Signaling Controls M. tuberculosis Infection

(2013) Mark Verway et al.   PLoS Pathogens

Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation

(2012) Chul-Su Yang et al.   Cell Host & Microbe

Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Inhibition Induces Neurotoxicity via Dysregulation of Glutamate/Calcium Signaling and Hyperexcitability

(2012) Nicole M. Ashpole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Janus-faced liposomes enhance antimicrobial innate immune response in Mycobacterium tuberculosis infection

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Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes

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Rab7: roles in membrane trafficking and disease

(2009) Ming Zhang et al.   BIOSCIENCE REPORTS

Downregulation of protein kinase C-alpha enhances intracellular survival of Mycobacteria: role of PknG

(2009) Shivendra K Chaurasiya et al.   BMC MICROBIOLOGY

Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells

(2009) Emanuela Greco et al.   IMMUNOLOGY

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols

The Toxoplasma gondii Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4

(2008) J. D. Dunn et al.   INFECTION AND IMMUNITY

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

(2008) Benjamin E. Steinberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Toxoplasma gondii induces prostaglandin E2 synthesis in macrophages via signal pathways for calcium-dependent arachidonic acid production and PKC-dependent induction of cyclooxygenase-2

(2008) Bi-Wen Peng et al.   PARASITOLOGY RESEARCH