TheToxoplasmaPseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPases

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors

(2013) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

(2013) Mary Christie et al.   MOLECULAR CELL

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

(2013) Jingtao Lilue et al.   eLife

Autophagy restrictsChlamydia trachomatisgrowth in human macrophages via IFNG-inducible guanylate binding proteins

(2012) Munir A. Al-Zeer et al.   Autophagy

Rab GTPase localization and Rab cascades in Golgi transport

(2012) Suzanne R. Pfeffer   BIOCHEMICAL SOCIETY TRANSACTIONS

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

The GTPase Activity of Murine Guanylate-binding Protein 2 (mGBP2) Controls the Intracellular Localization and Recruitment to the Parasitophorous Vacuole ofToxoplasma gondii

(2012) Elisabeth Kravets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

(2012) A. R. Shenoy et al.   SCIENCE

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

(2012) C. L. Gee et al.   Science Signaling

Virulence without catalysis: how can a pseudokinase affect host cell signaling?

(2012) Michael L. Reese et al.   TRENDS IN PARASITOLOGY

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

(2012) Michael S. Behnke et al.   PLoS Pathogens

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii

(2011) Nikolaus Pawlowski et al.   BMC BIOLOGY

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

(2011) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens

(2010) Julia P. Hunn et al.   MAMMALIAN GENOME

G domain dimerization controls dynamin's assembly-stimulated GTPase activity

(2010) Joshua S. Chappie et al.   NATURE

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DnaSP v5: a software for comprehensive analysis of DNA polymorphism data

(2009) P. Librado et al.   BIOINFORMATICS

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

(2009) Koichi Fukuda et al.   MOLECULAR CELL

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

ROP2 from Toxoplasma gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity

(2009) Gilles Labesse et al.   STRUCTURE

GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission

(2008) Pavel V. Bashkirov et al.   CELL

Real-Time Visualization of Dynamin-Catalyzed Membrane Fission and Vesicle Release

(2008) Thomas J. Pucadyil et al.   CELL

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL