Toxoplasma GRA 15 limits parasite growth in IFN γ‐activated fibroblasts through TRAF ubiquitin ligases

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

(2019) Yifan Wang et al.   mBio

Defining host–pathogen interactions employing an artificial intelligence workflow

(2019) Daniel Fisch et al.   eLife

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors

(2019) Lamba Omar Sangaré et al.   mBio

The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING

(2019) Peiyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell’s Early Response to Toxoplasma , Including Counteracting MYR1-Independent Effects

(2018) Adit Naor et al.   mBio

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

(2018) Hironori Bando et al.   Frontiers in Immunology

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells againstToxoplasma gondii

(2017) Aiping Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human immune response to Toxoplasma: Autophagy versus cell death

(2017) Shruthi Krishnamurthy et al.   PLoS Pathogens

TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles

(2017) Clémence Foltz et al.   Scientific Reports

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Human GBP1 does not localize to pathogen vacuoles but restrictsToxoplasma gondii

(2016) Ashleigh C. Johnston et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells

(2016) Barbara Clough et al.   PLoS Pathogens

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

(2016) Elisabeth Kravets et al.   eLife

Unveiling the pathogen behind the vacuole

(2015) Peter Liehl et al.   NATURE REVIEWS MICROBIOLOGY

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

(2015) Arun K. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

(2015) Youngae Lee et al.   Cell Reports

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii

(2015) Michael S. Behnke et al.   PLoS Genetics

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications

(2014) Uwe Pleyer et al.   OPHTHALMIC RESEARCH

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

(2013) Sam Strickson et al.   BIOCHEMICAL JOURNAL

Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains

(2013) Ninghan Yang et al.   BMC GENOMICS

Cell Death of Gamma Interferon-Stimulated Human Fibroblasts upon Toxoplasma gondii Infection Induces Early Parasite Egress and Limits Parasite Replication

(2013) Wendy Niedelman et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

(2011) Jonathan C Howard et al.   CURRENT OPINION IN MICROBIOLOGY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It

(2011) Sebastian Virreira Winter et al.   PLoS One

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Identification of a consensus site for TRAF6/p62 polyubiquitination

(2008) Trafina Jadhav et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL