Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage

(2010) Benjamin Gauter-Fleckenstein et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents againstHelicobacter pyloriInfection

(2009) Nunilo Cremades et al.   ACS Chemical Biology

Manganese Corroles Prevent Intracellular Nitration and Subsequent Death of Insulin-Producing Cells

(2009) Zoya Okun et al.   ACS Chemical Biology

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Protonated Nanoparticle Surface Governing Ligand Tethering and Cellular Targeting

(2009) Abhilash Vincent et al.   ACS Nano

NADPH oxidases and reactive oxygen species at different stages of chronic hypoxia-induced pulmonary hypertension in newborn piglets

(2009) Kathleen E. Dennis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Superoxide Anion Regulates the Mitochondrial Free Ca2+ Through Uncoupling Proteins

(2009) Zhaofei Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

(2009) Martin D. Rees et al.   BIOCHEMICAL JOURNAL

Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

(2009) Noriyuki Matsukawa et al.   BMC NEUROSCIENCE

Radioprotective Effect of a Metalloporphyrin Compound in Rat Eye Model

(2009) X. W. Mao et al.   CURRENT EYE RESEARCH

Superoxide dismutase activity of corrole metal complexes

(2009) Meital Eckshtain et al.   DALTON TRANSACTIONS

Antioxidants and Novel Therapeutics

(2009)   FREE RADICAL BIOLOGY AND MEDICINE

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells

(2009) Julianne M. Pollard et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat

(2009) Huaxin Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of potent porphyrin-based antioxidants: Comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins

(2009) Ivan Kos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo

(2009) Grigory V. Andrievsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of lipophilicity of Mn (III)ortho N-alkylpyridyl- and diortho N,N′-diethylimidazolylporphyrins in twoin-vitromodels of oxygen and glucose deprivation-induced neuronal death

(2009) Lisa Wise-Faberowski et al.   FREE RADICAL RESEARCH

Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury

(2009) Tiziana Genovese et al.   FREE RADICAL RESEARCH

Orally available Mn porphyrins with superoxide dismutase and catalase activities

(2009) Rosalind A. Rosenthal et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Brachytherapy for cervix cancer: low-dose rate or high-dose rate brachytherapy – a meta-analysis of clinical trials

(2009) Gustavo A Viani et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

High Lipophilicity of meta Mn(III)N-Alkylpyridylporphyrin-Based Superoxide Dismutase Mimics Compensates for Their Lower Antioxidant Potency and Makes Them as Effective as Ortho Analogues in Protecting Superoxide Dismutase-DeficientEscherichia coli

(2009) Ivan Kos et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Manganese Complex Effective as Superoxide Anion Scavenger and Therapeutic Agent against Cell and Tissue Oxidative Injury

(2009) Paola Failli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics

(2009) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Manganese import is a key element of the OxyR response to hydrogen peroxide inEscherichia coli

(2009) Adil Anjem et al.   MOLECULAR MICROBIOLOGY

Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

(2009) Jimmie Colon et al.   Nanomedicine-Nanotechnology Biology and Medicine

Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance

(2009) T. Doyle et al.   NEUROSCIENCE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor detection and elimination by a targeted gallium corrole

(2009) H. Agadjanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn Vivo

(2009) Michael W. Epperly et al.   RADIATION RESEARCH

Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants

(2009) Linsey Robertson et al.   TETRAHEDRON

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats

(2008) Parveen Abidi et al.   AGING CELL

Role of oxidative stress in multiparity-induced endothelial dysfunction

(2008) Huda E. Tawfik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Amphiphilic/Bipolar Metallocorroles That Catalyze the Decomposition of Reactive Oxygen and Nitrogen Species, Rescue Lipoproteins from Oxidative Damage, and Attenuate Atherosclerosis in Mice

(2008) Adi Haber et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Based Therapeutics for Lung Diseases

(2008) Yuma Hoshino et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Regulated Mechanisms in Asthma

(2008) Tomoaki Hoshino et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

(2008) Wei Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications

(2008) Cecilia Hidalgo et al.   ANTIOXIDANTS & REDOX SIGNALING

Catalytic Antioxidants and Neurodegeneration

(2008) Tamara R. Golden et al.   ANTIOXIDANTS & REDOX SIGNALING

SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

(2008) Gilson DeFreitas-Silva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

(2008) Barry Halliwell   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Antioxidative effects of statins

(2008) Oliver Adam et al.   ARCHIVES OF TOXICOLOGY

Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity

(2008) Dirk M. Maybauer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Honokiol is a potent scavenger of superoxide and peroxyl radicals

(2008) Sergey Dikalov et al.   BIOCHEMICAL PHARMACOLOGY

Catalase and glutathione peroxidase mimics

(2008) Brian J. Day   BIOCHEMICAL PHARMACOLOGY

Targeting lipophilic cations to mitochondria

(2008) Michael P. Murphy   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Protein and lipid nitration: Role in redox signaling and injury

(2008) Homero Rubbo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of cerium redox state in the SOD mimetic activity of nanoceria

(2008) Eric G. Heckert et al.   BIOMATERIALS

The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials

(2008) Jun-Jie Yin et al.   BIOMATERIALS

Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes

(2008) Wonchoul Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nitric Oxide and Nitroxides Can Act as Efficient Scavengers of Protein-Derived Free Radicals

(2008) Magdalena A. Lam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

(2008) Zoltan Ungvari et al.   CIRCULATION RESEARCH

Efficacy of Superoxide Dismutase Mimetic M40403 in Attenuating Radiation-Induced Oral Mucositis in Hamsters

(2008) C. K. Murphy et al.   CLINICAL CANCER RESEARCH

Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results

(2008) Robert J. Amato et al.   Clinical Genitourinary Cancer

Inflammation and immunity in diabetic vascular complications

(2008) Jan Nilsson et al.   CURRENT OPINION IN LIPIDOLOGY

Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: The effect of charge distribution

(2008) Júlio S. Rebouças et al.   DALTON TRANSACTIONS

Fenton-Like Reaction Catalyzed by the Rare Earth Inner Transition Metal Cerium

(2008) Eric G. Heckert et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy

(2008) Manish Arora et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells

(2008) Filip Matthijssens et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: Protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier

(2008) Júlio S. Rebouças et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells

(2008) Elvis Pirev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative and nitrative stress markers in glaucoma

(2008) Mutay Aslan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-κB, and JNK pathways

(2008) Claudia Fiorillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease

(2008) Marcus W. Brazier et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP5+, in plasma and major organs of B6C3F1 mice

(2008) Ivan Spasojević et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nitrones as therapeutics

(2008) Robert A. Floyd et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein tyrosine nitration—Functional alteration or just a biomarker?

(2008) José M. Souza et al.   FREE RADICAL BIOLOGY AND MEDICINE

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in diseases of the human cornea

(2008) Akiva Shoham et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection

(2008) Amit R. Reddi et al.   FREE RADICAL BIOLOGY AND MEDICINE

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation

(2008) Ines Batinic-Haberle et al.   FREE RADICAL RESEARCH

Antioxidant properties of MitoTEMPOL and its hydroxylamine

(2008) Jan Trnka et al.   FREE RADICAL RESEARCH

Oxidative Inactivation of Key Mitochondrial Proteins Leads to Dysfunction and Injury in Hepatic Ischemia Reperfusion

(2008) Kwan–Hoon Moon et al.   GASTROENTEROLOGY

Postnatal Intermittent Hypoxia and Developmental Programming of Hypertension in Spontaneously Hypertensive Rats

(2008) Galia K. Soukhova-O'Hare et al.   HYPERTENSION

Evaluation of EUK-189, a Synthetic Superoxide Dismutase/Catalase Mimetic as a Radiation Countermeasure

(2008) Venkataraman Srinivasan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Solvent, Anion, and Structural Effects on the Redox Potentials and UV−visible Spectral Properties of Mononuclear Manganese Corroles

(2008) Jing Shen et al.   INORGANIC CHEMISTRY

Motexafin Gadolinium Combined With Prompt Whole Brain Radiotherapy Prolongs Time to Neurologic Progression in Non–Small-Cell Lung Cancer Patients With Brain Metastases: Results of a Phase III Trial

(2008) Minesh P. Mehta et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Brain mitochondrial dysfunction in aging

(2008) Alberto Boveris et al.   IUBMB LIFE

Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics

(2008) Shinya Toyokuni   IUBMB LIFE

Inflammation and endothelial dysfunction during aging: role of NF-κB

(2008) Anna Csiszar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes

(2008) Júlio S. Rebouças et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart

(2008) Y. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging

(2008) Fuminori Hyodo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pulse Radiolysis Investigation on the Mechanism of the Catalytic Action of Mn(II)−Pentaazamacrocycle Compounds as Superoxide Dismutase Mimetics

(2008) Andrej Maroz et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Kinetics of the Reaction between Nitroxide and Thiyl Radicals: Nitroxides as Antioxidants in the Presence of Thiols

(2008) Sara Goldstein et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Manganous Phosphate Acts as a Superoxide Dismutase

(2008) Kevin Barnese et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans

(2008) Juewon Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Suppression of Cancer Invasiveness by Dietary Compounds

(2008) Daniel Sliva   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice

(2008) Aaron Clausen et al.   NEUROBIOLOGY OF AGING

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

(2008) P. Sompol et al.   NEUROSCIENCE

Chemistry and Antihypertensive Effects of Tempol and Other Nitroxides

(2008) C. S. Wilcox et al.   PHARMACOLOGICAL REVIEWS

Mechanisms of disease: The oxidative stress theory of diabetic neuropathy

(2008) Claudia Figueroa-Romero et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Facile synthesis of ortho-pyridyl-substituted corroles and molecular structures of analogous porphyrins

(2008) Irena Saltsman et al.   TETRAHEDRON LETTERS

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES

Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials

(2007) Alexios S. Strimpakos et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants as Potential Therapeutics for Lung Fibrosis

(2007) Brian J. Day   ANTIOXIDANTS & REDOX SIGNALING

Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

(2007) Benjamin Gauter-Fleckenstein et al.   FREE RADICAL BIOLOGY AND MEDICINE

A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice

(2006) Kevin L. Quick et al.   NEUROBIOLOGY OF AGING