Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

(2018) Yuqing Liu et al.   Oxidative Medicine and Cellular Longevity

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

(2018) Anna Picca et al.   REJUVENATION RESEARCH

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

(2017) Guoying Yu et al.   NATURE MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

(2017) Lucy A. Murtha et al.   Frontiers in Physiology

Toll-Interacting Protein in Resolving and Non-Resolving Inflammation

(2017) Elizabeth J. A. Kowalski et al.   Frontiers in Immunology

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

(2017) Viktor I. Korolchuk et al.   EBioMedicine

The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

(2017) Michael Schuliga et al.   Scientific Reports

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

(2016) Yair Romero et al.   AGING CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria and senescence: new actors for an old play

(2016) Nicolás Herranz et al.   EMBO JOURNAL

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

(2016) Vicente Martínez-Redondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander?

(2016) David J. Rowlands   PHARMACOLOGY & THERAPEUTICS

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

(2016) Paul F Mercer et al.   THORAX

Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

(2016) Aleksandra Borodkina et al.   Aging-US

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis

(2016) Supparerk Disayabutr et al.   PLoS One

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

Mitochondrial-Targeted Antioxidant Therapy Decreases Transforming Growth Factor-β–Mediated Collagen Production in a Murine Asthma Model

(2015) Omar A. Jaffer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The hitchhiker’s guide to PGC-1α isoform structure and biological functions

(2015) Vicente Martínez-Redondo et al.   DIABETOLOGIA

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

(2015) Seok-Jo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases

(2014) Richard Seonghun Nho et al.   PLoS One

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Airway smooth muscle remodels pericellular collagen fibrils: implications for proliferation

(2010) Michael Schuliga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Fibrillar Collagen Clamps Lung Mesenchymal Cells in a Nonproliferative and Noncontractile Phenotype

(2009) Michael J. Schuliga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Use of Senescence-Accelerated Mouse Model in Bleomycin-Induced Lung Injury Suggests That Bone Marrow-Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice

(2009) J. Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES