Advances in TRP channel drug discovery: from target validation to clinical studies
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Title
Advances in TRP channel drug discovery: from target validation to clinical studies
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-15
DOI
10.1038/s41573-021-00268-4
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- Transient receptor potential genes, smoking, occupational exposures and cough in adults
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- An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
- (2012) Kevin S. Thorneloe et al. Science Translational Medicine
- Transient receptor potential channels mediate the tussive response to prostaglandin E2and bradykinin
- (2012) Megan Grace et al. THORAX
- Therapeutic Targeting of TRP Channels - The TR(i)P to Pain Relief
- (2011) Samer R. Eid CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels
- (2011) Melissa Miller et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia
- (2011) Lucia Seminario-Vidal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth
- (2011) István Borbíró et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells
- (2011) Indranil Mukhopadhyay et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Transient receptor potential channels as therapeutic targets
- (2011) Magdalene M. Moran et al. NATURE REVIEWS DRUG DISCOVERY
- TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
- (2011) Joris Vriens et al. NEURON
- Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
- (2011) Romina Nassini et al. PAIN
- Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
- (2011) Ari Koivisto et al. PHARMACOLOGICAL RESEARCH
- Evaluation of exhaled breath condensate pH as a biomarker for COPD
- (2011) William MacNee et al. RESPIRATORY MEDICINE
- A role for sensory nerves in the late asthmatic response
- (2011) Kristof Raemdonck et al. THORAX
- TRPV4 channels augment macrophage activation and ventilator-induced lung injury
- (2010) Kazutoshi Hamanaka et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis
- (2010) Nicolas Riteau et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation
- (2010) Xiping Cheng et al. CELL
- TRPV1-lineage neurons are required for thermal sensation
- (2010) Santosh K Mishra et al. EMBO JOURNAL
- Motor impairment in Alzheimer’s disease and transgenic Alzheimer’s disease mouse models
- (2010) O. Wirths et al. GENES BRAIN AND BEHAVIOR
- Loss of Function of Transient Receptor Potential Vanilloid 1 (TRPV1) Genetic Variant Is Associated with Lower Risk of Active Childhood Asthma
- (2010) Gerard Cantero-Recasens et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
- (2010) Barbara Kremeyer et al. NEURON
- TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
- (2010) Wendy M. Knowlton et al. PAIN
- International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
- (2010) L.-J. Wu et al. PHARMACOLOGICAL REVIEWS
- Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
- (2010) W. Everaerts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers
- (2009) Mark A. Birrell et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents
- (2009) E Andrè et al. BRITISH JOURNAL OF PHARMACOLOGY
- Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior
- (2009) Antonio Riccio et al. CELL
- Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease
- (2009) G. Zhu et al. HUMAN MOLECULAR GENETICS
- Role of TRPV3 in immune response to development of dermatitis
- (2009) Kinichi Imura et al. Journal of Inflammation-London
- De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
- (2009) Volodymyr Gerzanich et al. NATURE MEDICINE
- The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not
- (2009) A. A. Romanovsky et al. PHARMACOLOGICAL REVIEWS
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
- (2009) A. I. Caceres et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transient Receptor Potential Ankyrin 1 Mediates Toluene Diisocyanate–Evoked Respiratory Irritation
- (2008) Thomas E. Taylor-Clark et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms
- (2008) Nicolas Cenac et al. GASTROENTEROLOGY
- TRPA1 is a major oxidant sensor in murine airway sensory neurons
- (2008) Bret F. Bessac et al. JOURNAL OF CLINICAL INVESTIGATION
- Impact of the Gly573Ser Substitution in TRPV3 on the Development of Allergic and Pruritic Dermatitis in Mice
- (2008) Takeshi Yoshioka et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
- (2008) K. S. Thorneloe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat
- (2008) Guangfan Zhang et al. JOURNAL OF PHYSIOLOGY-LONDON
- GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models
- (2008) Ana Charrua et al. JOURNAL OF UROLOGY
- A primer on ankyrin repeat function in TRP channels and beyond
- (2008) Rachelle Gaudet Molecular BioSystems
- Transient receptor potential channels: targeting pain at the source
- (2008) Ardem Patapoutian et al. NATURE REVIEWS DRUG DISCOVERY
- Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
- (2008) Narender R. Gavva et al. PAIN
- Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
- (2008) Bret F. Bessac et al. PHYSIOLOGY
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