TRPA1 deficiency is protective in cuprizone-induced demyelination-A new target against oligodendrocyte apoptosis

Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia

(2016) Nicola B. Hamilton et al.   NATURE

STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury

(2016) Amber R. Hackett et al.   NEUROBIOLOGY OF DISEASE

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

(2015) Dmitry Petrov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury

(2015) Jae Young Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons

(2015) Masaya Watanabe et al.   PLoS One

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

(2014) O. Delgado et al.   CLINICAL CANCER RESEARCH

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

(2014) Gabriela Trevisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators

(2014) Yangfan P. Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis

(2014) Jennifer J. DeBerry et al.   PAIN

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Transient receptor potential (TRP) channels in the airway: role in airway disease

(2013) M S Grace et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model

(2013) P. Acs et al.   JOURNAL OF NEUROIMMUNOLOGY

TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release

(2013) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Cuprizone [Bis(Cyclohexylidenehydrazide)] is Selectively Toxic for Mature Oligodendrocytes

(2013) Karelle Bénardais et al.   NEUROTOXICITY RESEARCH

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus

(2012) Sang Man Lee et al.   JOURNAL OF CHEMICAL NEUROANATOMY

5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals

(2012) M. Sisignano et al.   JOURNAL OF NEUROSCIENCE

IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

(2012) Z. Kang et al.   JOURNAL OF NEUROSCIENCE

Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain

(2012) Takashi Kondo et al.   NEUROREPORT

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals

(2012) Arianne L. Motter et al.   PLoS One

Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

(2011) O Gomez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ghrelin Inhibits Hydrogen Peroxide-Induced Apoptotic Cell Death of Oligodendrocytes Via ERK and p38MAPK Signaling

(2011) Jee Y. Lee et al.   ENDOCRINOLOGY

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Dual-specific Phosphatase-6 (Dusp6) and ERK Mediate AMPA Receptor-induced Oligodendrocyte Death

(2011) Maria Domercq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

(2011) Elke Verena Voß et al.   NEUROBIOLOGY OF DISEASE

Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

(2011) Viktoria Gudi et al.   PLoS One

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death

(2010) S. Veto et al.   BRAIN

Role of Transient Receptor Potential A1 in Gastric Nociception

(2010) Takashi Kondo et al.   DIGESTION

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Regional differences between grey and white matter in cuprizone induced demyelination

(2009) Viktoria Gudi et al.   BRAIN RESEARCH

Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats

(2009) T Kondo et al.   GUT

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

TRPA1: A potential target for anti-tussive therapy

(2009) Thomas E. Taylor-Clark et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The cuprizone model for demyelination

(2008) Ø. Torkildsen et al.   ACTA NEUROLOGICA SCANDINAVICA

17β-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice

(2008) Peter Acs et al.   GLIA

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Inhibition of p53 Transcriptional Activity: A Potential Target for Future Development of Therapeutic Strategies for Primary Demyelination

(2008) J. Li et al.   JOURNAL OF NEUROSCIENCE

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

(2008) T. E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

(2008) Lillian Cruz-Orengo et al.   Molecular Pain

Olig2-expressing progenitor cells preferentially differentiate into oligodendrocytes in cuprizone-induced demyelinated lesions

(2008) Mohammad Shyful Islam et al.   NEUROCHEMISTRY INTERNATIONAL