Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase IIb randomized trial

A novel, topical, nonsteroidal, TRPV1 antagonist, PAC-14028 cream improves skin barrier function and exerts anti-inflammatory action through modulating epidermal differentiation markers and suppressing Th2 cytokines in atopic dermatitis

(2018) Ji-Hae Lee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Emerging therapies for atopic dermatitis: TRPV1 antagonists

(2018) Jonathan G. Bonchak et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Emerging therapies for atopic dermatitis: JAK inhibitors

(2018) David G. Cotter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Therapeutic pipeline for atopic dermatitis: End of the drought?

(2017) Amy S. Paller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atopic Dermatitis in Adults: A Diagnostic Challenge

(2017) JF Silvestre Salvador et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults

(2016) Amy S. Paller et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Self-maintenance of neurogenic inflammation contributes to a vicious cycle in skin

(2015) Olivier Gouin et al.   EXPERIMENTAL DERMATOLOGY

A comparison of radio-frequency biomotion sensors and actigraphy versus polysomnography for the assessment of sleep in normal subjects

(2014) Emer O’Hare et al.   Sleep and Breathing

Itch and Pain in Adolescents are Associated with Suicidal Ideation: A Population-based Cross-sectional Study

(2013) J Halvorsen et al.   ACTA DERMATO-VENEREOLOGICA

Mast cell activation contributes to sickle cell pathobiology and pain in mice

(2013) L. Vincent et al.   BLOOD

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases

(2012) Kyung-Min Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Antipruritic Effects of TRPV1 Antagonist in Murine Atopic Dermatitis and Itching Models

(2011) Jun-Won Yun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Management of Itch in Atopic Dermatitis

(2011) Judith Hong et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE