TRPV1: Structure, Endogenous Agonists, and Mechanisms

Structural mechanisms of transient receptor potential ion channels

(2020) Erhu Cao   JOURNAL OF GENERAL PHYSIOLOGY

Two Vanilloid Ligand Bindings Per Channel Are Required to Transduce Capsaicin-Activating Stimuli

(2020) Ting-Yi Liu et al.   Frontiers in Molecular Neuroscience

Effects of TRPV1 Activation by Capsaicin and Endogenous N-Arachidonoyl Taurine on Synaptic Transmission in the Prefrontal Cortex

(2020) Mingyue Zhang et al.   Frontiers in Neuroscience

Structural biology of thermoTRPV channels

(2019) Peng Yuan   CELL CALCIUM

The role of lysophosphatidic acid on ion channel function and disease

(2018) Ileana Hernández-Araiza et al.   JOURNAL OF NEUROPHYSIOLOGY

Different agonists induce distinct single-channel conductance states in TRPV1 channels

(2018) Jesús Aldair Canul-Sánchez et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV1 pore turret dictates distinct DkTx and capsaicin gating

(2018) Matan Geron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1

(2017) Hiroki Kittaka et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

(2017) Yelena Nersesyan et al.   Cell Reports

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

(2017) Fan Yang et al.   Protein & Cell

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

(2017) Ximena Steinberg et al.   eLife

Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical and thermal allodynia after burn injury

(2016) Dustin P Green et al.   Molecular Pain

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

An external sodium ion binding site controls allosteric gating in TRPV1 channels

(2016) Andres Jara-Oseguera et al.   eLife

The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels

(2015) Stefania Petrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test

(2015) Myrna Déciga-Campos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

(2015) Khaled Elokely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

(2015) Shilong Yang et al.   Nature Communications

Structural Determinants of the Transient Receptor Potential 1 (TRPV1) Channel Activation by Phospholipid Analogs

(2014) Sara L. Morales-Lázaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain

(2014) Yongwoo Jang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

N-Acylethanolamines: lipid metabolites with functions in plant growth and development

(2014) Elison B. Blancaflor et al.   PLANT JOURNAL

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

(2014) Siham Raboune et al.   Frontiers in Cellular Neuroscience

Discovery of a novel iota carrageenan sulfatase isolated from the marine bacterium Pseudoalteromonas carrageenovora

(2014) Sabine M. Genicot et al.   Frontiers in Chemistry

H2S modulates duodenal motility in male rats via activating TRPV1 and KATPchannels

(2013) Wen Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coarse Architecture of the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel Determined by Fluorescence Resonance Energy Transfer

(2013) Víctor De-la-Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

(2013) Fan Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)

(2013) Sara L. Morales-Lázaro et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Identification of the sensory nerve fiber responsible for lysophosphatidic acid-induced allodynia in mice

(2013) M. Ohsawa et al.   NEUROSCIENCE

Lysophosphatidic acid: Chemical signature of neuropathic pain

(2012) Hiroshi Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms

(2012) Mohammad Alsalem et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide

(2012) Paolo Ambrosino et al.   BRITISH JOURNAL OF PHARMACOLOGY

20-Hydroxyeicosatetraenoic Acid (20-HETE) Is a Novel Activator of Transient Receptor Potential Vanilloid 1 (TRPV1) Channel

(2012) Hairuo Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding

(2012) Vsevolod Telezhkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors

(2012) A. M. Gregus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The endocannabinoid system: an overview

(2012) Natalia Battista et al.   Frontiers in Behavioral Neuroscience

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

(2010) Stefania Petrosino et al.   BIOCHIMIE

N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets

(2010) Mark Connor et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

(2010) Amol M. Patwardhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual Roles for RHOA/RHO-Kinase In the Regulated Trafficking of a Voltage-sensitive Potassium Channel

(2009) Lee Stirling et al.   MOLECULAR BIOLOGY OF THE CELL

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

(2009) A. M. Patwardhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Entourage’ effects ofN-palmitoylethanolamide andN-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

(2008) W-SV Ho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo

(2008) Róbert Almási et al.   LIFE SCIENCES

Direct Activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

(2008) Dong Ho Woo et al.   Molecular Pain

Autotaxin, a Synthetic Enzyme of Lysophosphatidic Acid (LPA), Mediates the Induction of Nerve-Injured Neuropathic Pain

(2008) Makoto Inoue et al.   Molecular Pain

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

(2008) Barbara Costa et al.   PAIN

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA