Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase

(2016) René Fuertig et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

(2016) Sonya G Lehto et al.   Molecular Pain

Critical roles of Gi/oproteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels

(2016) Dhananjay P. Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

(2015) Li-Ping Yang et al.   PLoS One

Modulation of K2P2.1 and K2P10.1 K+channel sensitivity to carvedilol by alternative mRNA translation initiation

(2014) J Kisselbach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Decreased Anxiety-Like Behavior and G q/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels

(2014) A. Riccio et al.   JOURNAL OF NEUROSCIENCE

Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function

(2014) Damiano Azzinnari et al.   NEUROPHARMACOLOGY

Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?

(2014) Alexander Dietrich et al.   Cells

The Neural Correlates of Anomalous Habituation to Negative Emotional Pictures in Borderline and Avoidant Personality Disorder Patients

(2013) Harold W. Koenigsberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

Increased Amygdala Responses to Sad But Not Fearful Faces in Major Depression: Relation to Mood State and Pharmacological Treatment

(2012) Danilo Arnone et al.   AMERICAN JOURNAL OF PSYCHIATRY

On the relationship between block of the cardiac Na+channel and drug-induced prolongation of the QRS complex

(2011) AR Harmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient Receptor Potential Channel 1 (TRPC1) Reduces Calcium Permeability in Heteromeric Channel Complexes

(2011) Ursula Storch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

(2011) Melissa Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residual Symptoms in Depressed Outpatients Who Respond by 50% But Do Not Remit to Antidepressant Medication

(2011) Shawn M. McClintock et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Establishing a learned-helplessness effect paradigm in C57BL/6 mice: Behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se

(2011) Christopher R. Pryce et al.   NEUROPHARMACOLOGY

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels

(2009) Nathaniel T. Blair et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Neurocircuitry of Fear, Stress and Anxiety Disorders

(2009) Lisa M Shin et al.   NEUROPSYCHOPHARMACOLOGY

The specific activation of TRPC4 by Gi protein subtype

(2008) Jae-Pyo Jeon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS