Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Transient Receptor Potential A1 Channels

(2011) Maria G. Belvisi et al.   CHEST

The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

(2011) Wouter Everaerts et al.   CURRENT BIOLOGY

Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy

(2011) M. M. Jack et al.   DIABETOLOGIA

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve

(2011) Magdalena Bremer et al.   GLIA

Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy

(2011) Teresa L. Cvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification ofin VivoDisulfide Conformation of TRPA1 Ion Channel

(2011) Liwen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TRPA1-dependent mechanism for the pungent sensation of weak acids

(2011) Yuanyuan Y. Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors

(2011) Rui Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

TRPV1, TRPA1, and CB1 in the isolated vagus nerve – Axonal chemosensitivity and control of neuropeptide release

(2011) K. Weller et al.   NEUROPEPTIDES

Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat

(2011) Hong Wei et al.   PAIN

Endothelin-1 and diabetic complications: Focus on the vasculature

(2011) Adviye Ergul   PHARMACOLOGICAL RESEARCH

Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy

(2010) Sébastien Talbot et al.   Journal of Neuroinflammation

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Is a Component of the Nociceptive Response to CO2

(2010) Y. Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat

(2010) Hong Wei et al.   NEUROSCIENCE LETTERS

Sensitized peripheral nociception in experimental diabetes of the rat

(2010) D. Fuchs et al.   PAIN

Gas-phase water-mediated equilibrium between methylglyoxal and its geminal diol

(2010) J. L. Axson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

(2009) K. Y. Kwan et al.   JOURNAL OF NEUROSCIENCE

Thermodynamics and Kinetics of Methylglyoxal Dimer Formation: A Computational Study

(2009) Hadley E. Krizner et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Neuropathic pain is associated with increased nodal persistent Na+ currents in human diabetic neuropathy

(2009) Sonoko Misawa et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Phenotyping sensory nerve endings in vitro in the mouse

(2009) Katharina Zimmermann et al.   Nature Protocols

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

(2009) Manuela Schmidt et al.   NEURON

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

(2009) Richard B. Messinger et al.   PAIN

Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients

(2008) Keisuke Nakayama et al.   AMERICAN JOURNAL OF NEPHROLOGY

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

(2008) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

(2008) T. E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Influence of TRPV1 on Diabetes-Induced Alterations in Thermal Pain Sensitivity

(2008) Reddy M Pabbidi et al.   Molecular Pain

Intact Aδ-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats

(2008) G. Ji et al.   NEUROSCIENCE

Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges

(2007) Roberto De Col et al.   JOURNAL OF PHYSIOLOGY-LONDON

Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors

(2007) Nikita B. Ruparel et al.   PAIN

Endothelin1 activates and sensitizes human C-nociceptors

(2007) Barbara Namer et al.   PAIN