A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
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Title
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 4, Pages -
Publisher
Rockefeller University Press
Online
2021-02-23
DOI
10.1084/jem.20201637
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Note: Only part of the references are listed.- Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma
- (2020) Rebecca M. Reese et al. Scientific Reports
- Development of AITC‐induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin
- (2020) Victory Joseph et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Irritant-evoked activation and calcium modulation of the TRPA1 receptor
- (2020) Jianhua Zhao et al. NATURE
- Allergen challenge increases capsaicin evoked cough responses in allergic asthma
- (2019) Imran Satia et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain
- (2019) Dustin P. Green et al. NEURON
- A human TRPA1-specific pain model
- (2019) Stefan Heber et al. JOURNAL OF NEUROSCIENCE
- Structural identification of a hotspot on CFTR for potentiation
- (2019) Fangyu Liu et al. SCIENCE
- Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel
- (2019) Yang Suo et al. NEURON
- Validation of antibodies for the specific detection of human TRPA1
- (2019) H. S. Virk et al. Scientific Reports
- TRP Channels as Potential Drug Targets
- (2018) Magdalene M. Moran Annual Review of Pharmacology and Toxicology
- Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
- (2018) Huifen Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
- (2018) Pankaj Baral et al. NATURE MEDICINE
- Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma
- (2018) Klaus F. Rabe et al. NEW ENGLAND JOURNAL OF MEDICINE
- An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts
- (2018) Daniel D. Bravo et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- cisTEM, user-friendly software for single-particle image processing
- (2018) Timothy Grant et al. eLife
- ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
- (2018) Tristan Ian Croll Acta Crystallographica Section D-Structural Biology
- Eosinophils increase airway sensory nerve density in mice and in human asthma
- (2018) Matthew G. Drake et al. Science Translational Medicine
- The emerging role of transient receptor potential channels in chronic lung disease
- (2017) Maria G. Belvisi et al. EUROPEAN RESPIRATORY JOURNAL
- Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction
- (2017) Imran Satia et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Human vs. Mouse Nociceptors – Similarities and Differences
- (2017) Charlotte Rostock et al. NEUROSCIENCE
- Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects
- (2017) Thuy Vu et al. PHARMACEUTICAL RESEARCH
- Whole-brain 3D mapping of human neural transplant innervation
- (2017) Jonas Doerr et al. Nature Communications
- Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies
- (2016) Maria G. Belvisi et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Biomarkers in the clinical development of asthma therapies
- (2016) Tracy L Staton et al. Biomarkers in Medicine
- TRPA1 activation leads to neurogenic vasodilatation: involvement of reactive oxygen nitrogen species in addition to CGRP and NO
- (2016) Aisah A Aubdool et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neuro-immune interactions in chemical-induced airway hyperreactivity
- (2016) Fien C. Devos et al. EUROPEAN RESPIRATORY JOURNAL
- Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
- (2016) Laurie B. Schenkel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Animal models of chronic pain: Advances and challenges for clinical translation
- (2016) Nicole E. Burma et al. JOURNAL OF NEUROSCIENCE RESEARCH
- TRPA1 channels: molecular sentinels of cellular stress and tissue damage
- (2016) Félix Viana JOURNAL OF PHYSIOLOGY-LONDON
- TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
- (2016) Yuan Gao et al. NATURE
- TRPA1gene polymorphisms and childhood asthma
- (2016) Valentina Gallo et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Vagal Afferent Innervation of the Airways in Health and Disease
- (2016) Stuart B. Mazzone et al. PHYSIOLOGICAL REVIEWS
- Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies
- (2016) Hector G Ortega et al. Lancet Respiratory Medicine
- Vagal Sensory Neuron Subtypes that Differentially Control Breathing
- (2015) Rui B. Chang et al. CELL
- Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms
- (2015) Candice E. Paulsen et al. NATURE
- TRPA1 as a drug target—promise and challenges
- (2015) Jun Chen et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
- (2015) Sébastien Talbot et al. NEURON
- Efficient conditional knockout targeting vector construction using co-selection BAC recombineering (CoSBR)
- (2015) Robert J. Newman et al. NUCLEIC ACIDS RESEARCH
- The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease
- (2015) Jose Ordovas-Montanes et al. TRENDS IN IMMUNOLOGY
- Fluorescent-Protein Stabilization and High-Resolution Imaging of Cleared, Intact Mouse Brains
- (2015) Martin K. Schwarz et al. PLoS One
- iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging
- (2014) Nicolas Renier et al. CELL
- Anatomy and Neurophysiology of Cough
- (2014) Brendan J. Canning et al. CHEST
- Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial
- (2014) Saifudin Khalid et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
- (2014) Lorena Riol-Blanco et al. NATURE
- Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma
- (2014) Hector G. Ortega et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Robust High Throughput Platform to Generate Functional Recombinant Monoclonal Antibodies Using Rabbit B Cells from Peripheral Blood
- (2014) Stefan Seeber et al. PLoS One
- Exploring the Effects of Omalizumab in Allergic Asthma
- (2013) Nicola A. Hanania et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Transient receptor potential (TRP) channels in the airway: role in airway disease
- (2013) M S Grace et al. BRITISH JOURNAL OF PHARMACOLOGY
- One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions
- (2013) Giovanni Cardone et al. JOURNAL OF STRUCTURAL BIOLOGY
- In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model
- (2013) Eva Nyman et al. Journal of Pain Research
- Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice
- (2012) Valérie Hox et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- TRPA1: A Gatekeeper for Inflammation
- (2012) Diana M. Bautista et al. Annual Review of Physiology
- IgE and mast cells in allergic disease
- (2012) Stephen J Galli et al. NATURE MEDICINE
- Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
- (2012) Isaac M Chiu et al. NATURE NEUROSCIENCE
- Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation
- (2012) Romina Nassini et al. PLoS One
- G-protein coupled receptors regulating cough
- (2011) Sarah A Maher et al. CURRENT OPINION IN PHARMACOLOGY
- Lebrikizumab Treatment in Adults with Asthma
- (2011) Jonathan Corren et al. NEW ENGLAND JOURNAL OF MEDICINE
- Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
- (2011) Jun Chen et al. PAIN
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose–petrosal ganglion complex
- (2010) Aki Hondoh et al. BRAIN RESEARCH
- Mechanisms of Dyspnea
- (2010) Nausherwan K. Burki et al. CHEST
- Interrupting the cough reflex in asthma
- (2010) Jaclyn A Smith Current Opinion in Allergy and Clinical Immunology
- Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos
- (2010) Marina Gertsenstein et al. PLoS One
- T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma
- (2009) Prescott G. Woodruff et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Ligands, their receptors and … plasma membranes
- (2009) G. Vauquelin et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
- (2009) A. I. Caceres et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity
- (2008) G. A. Mostafa et al. ALLERGY
- TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus
- (2008) Shaoyong Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Hypertonic saline cough provocation test with salbutamol pre-treatment: evidence for sensorineural dysfunction in asthma
- (2008) H. O. Koskela et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases
- (2008) Bret F. Bessac et al. FASEB JOURNAL
- TRPA1 is a major oxidant sensor in murine airway sensory neurons
- (2008) Bret F. Bessac et al. JOURNAL OF CLINICAL INVESTIGATION
- Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs
- (2008) Christina Nassenstein et al. JOURNAL OF PHYSIOLOGY-LONDON
- Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels
- (2008) K. Nagatomo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using guinea pigs in studies relevant to asthma and COPD
- (2008) Brendan J. Canning et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
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