Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders
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Title
Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders
Authors
Keywords
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Journal
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-07-02
DOI
10.1007/s12035-021-02472-0
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Note: Only part of the references are listed.- Biglycan protects human neuroblastoma cells from nitric oxide-induced death by inhibiting AMPK-mTOR mediated autophagy and intracellular ROS level
- (2020) Sujuan Chen et al. BIOTECHNOLOGY LETTERS
- Autophagy in Parkinson's Disease
- (2020) Xu Hou et al. JOURNAL OF MOLECULAR BIOLOGY
- Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
- (2020) Olga Corti et al. JOURNAL OF NEUROCHEMISTRY
- MicroRNAs: Game Changers in the Regulation of α-Synuclein in Parkinson’s Disease
- (2019) Liang Zhao et al. Parkinsons Disease
- Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
- (2019) Fiona Limanaqi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Cleaning Crew: The Pursuit of Autophagy in Parkinson’s Disease
- (2019) Pathik Parekh et al. ACS Chemical Neuroscience
- Neuroprotective effects of memantine via enhancement of autophagy
- (2019) Kazuoki Hirano et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease
- (2019) Kai-Jung Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The vicious cycle between α ‐synuclein aggregation and autophagic‐lysosomal dysfunction
- (2019) Giovanni Bellomo et al. MOVEMENT DISORDERS
- Astrocytes autophagy in aging and neurodegenerative disorders
- (2019) Jun-Ling Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo
- (2018) Monika Kustermann et al. Autophagy
- Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly
- (2018) Salinee Jantrapirom et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease
- (2018) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy
- (2018) Xiaodan Guo et al. NEUROPHARMACOLOGY
- Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates
- (2018) Jing Sun et al. Cell Death & Disease
- Autophagy: The Last Defense against Cellular Nutritional Stress
- (2018) Long He et al. Advances in Nutrition
- Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective
- (2018) S. N. Suresh et al. Frontiers in Molecular Neuroscience
- Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum
- (2018) Yanan Luan et al. Frontiers in Neuroscience
- Life, death and autophagy
- (2018) Johnna Doherty et al. NATURE CELL BIOLOGY
- A role for autophagy in Huntington's disease
- (2018) Katherine R. Croce et al. NEUROBIOLOGY OF DISEASE
- Glycyrrhizic Acid Alleviates 6-Hydroxydopamine and Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells Through Modulating Autophagy
- (2018) Guangyi Yang et al. NEUROCHEMICAL RESEARCH
- E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
- (2018) Jia-qing Yan et al. MOLECULES
- The role of neurovascular unit damage in the occurrence and development of Alzheimer’s disease
- (2018) Xin Liu et al. REVIEWS IN THE NEUROSCIENCES
- Autophagy impairment in Parkinson’s disease
- (2017) Cansu Karabiyik et al. Essays in Biochemistry
- Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease
- (2017) Min Huang et al. EXPERIMENTAL GERONTOLOGY
- Detection of long repeat expansions from PCR-free whole-genome sequence data
- (2017) Egor Dolzhenko et al. GENOME RESEARCH
- Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
- (2017) Ainhoa Plaza-Zabala et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Seeking new anti-cancer agents from autophagy-regulating natural products
- (2017) Fang Hua et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
- (2017) Michael C. Chang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Polyglutamine tracts regulate beclin 1-dependent autophagy
- (2017) Avraham Ashkenazi et al. NATURE
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome–lysosome fusion
- (2017) Victor Bustos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS
- (2017) Noam D. Rudnick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease
- (2017) Khaled S. Abd-Elrahman et al. Science Signaling
- Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy
- (2017) Shu Zhang et al. Cell Death & Disease
- Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
- (2017) Ismael Al-Ramahi et al. eLife
- Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
- (2017) Prasad Tammineni et al. eLife
- mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease
- (2017) Khaled S. Abd-Elrahman et al. Science Signaling
- Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function
- (2017) Chul Ju Hwang et al. Redox Biology
- Amyloid-β1-42 Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in U87 and SH-SY5Y Cells
- (2017) Hongmei Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Mammalian Autophagy: How Does It Work?
- (2016) Carla F. Bento et al. Annual Review of Biochemistry
- Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes
- (2016) Marta Pajares et al. Autophagy
- Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
- (2016) Alice Goode et al. Autophagy
- Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2
- (2016) Mayuko Osaka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Alzheimer's disease genes and autophagy
- (2016) Seung-Yong Yoon et al. BRAIN RESEARCH
- Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
- (2016) Chantal Sellier et al. EMBO JOURNAL
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation
- (2016) Sung Min Son et al. JOURNAL OF ALZHEIMERS DISEASE
- Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions
- (2016) Tiffany W. Todd et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage
- (2016) Bangqing Yuan et al. MOLECULAR NEUROBIOLOGY
- Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease
- (2016) Kunie Ando et al. NEUROBIOLOGY OF DISEASE
- Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro
- (2016) Carolin Walter et al. NEUROPHARMACOLOGY
- Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linkedUBQLN2mutations
- (2016) Nhat T. T. Le et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
- (2016) Andrew S. Moore et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
- (2016) Faxiang Li et al. Nature Communications
- Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson’s disease model
- (2016) Jia Liu et al. Oncotarget
- Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies
- (2016) Maria Jimenez-Sanchez et al. Cold Spring Harbor Perspectives in Medicine
- Role of Chaperone-Mediated Autophagy Dysfunctions in the Pathogenesis of Parkinson’s Disease
- (2016) Gessica Sala et al. Frontiers in Molecular Neuroscience
- Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria
- (2015) Yvette C Wong et al. Autophagy
- Role of autophagy in metabolic syndrome-associated heart disease
- (2015) Sidney Y. Ren et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Autophagy: A housekeeper in cardiorenal metabolic health and disease
- (2015) Guanghong Jia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Autophagy and cell reprogramming
- (2015) Shuo Wang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Autophagy in stem and progenitor cells
- (2015) Carlo Rodolfo et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity
- (2015) Malte Butzlaff et al. HUMAN MOLECULAR GENETICS
- Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis
- (2015) Vinod Sundaramoorthy et al. HUMAN MOLECULAR GENETICS
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment
- (2015) Sylvia E. Perez et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- (2015) F.-L. Tang et al. JOURNAL OF NEUROSCIENCE
- Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation
- (2015) Yi-Sheng Hou et al. MOLECULAR AND CELLULAR BIOLOGY
- Neferine Attenuates the Protein Level and Toxicity of Mutant Huntingtin in PC-12 Cells via Induction of Autophagy
- (2015) Vincent Wong et al. MOLECULES
- Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
- (2015) Jihoon Nah et al. MOLECULES AND CELLS
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
- (2015) Rushika M. Perera et al. NATURE
- Huntingtin functions as a scaffold for selective macroautophagy
- (2015) Yan-Ning Rui et al. NATURE CELL BIOLOGY
- Compromised autophagy and neurodegenerative diseases
- (2015) Fiona M. Menzies et al. NATURE REVIEWS NEUROSCIENCE
- Huntington Disease
- (2015) Praveen Dayalu et al. NEUROLOGIC CLINICS
- The autophagy-lysosomal pathway
- (2015) Daniel L. Kenney et al. NEUROLOGY
- Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy
- (2015) Valerie Uytterhoeven et al. NEURON
- Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model
- (2015) Y. Li et al. NEUROSCIENCE
- Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations
- (2015) Lydia Chang et al. PLoS One
- Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein
- (2015) Kiri Kilpatrick et al. PLoS One
- MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
- (2015) Diego Ploper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy in Huntington disease and huntingtin in autophagy
- (2015) Dale D.O. Martin et al. TRENDS IN NEUROSCIENCES
- Chaperone-mediated autophagy: roles in neuroprotection
- (2015) Zhibiao Cai et al. Neuroscience Bulletin
- Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
- (2015) Junghyun Lim et al. PLoS Genetics
- VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo
- (2015) Alyssa E Johnson et al. eLife
- Alpha-synuclein degradation by autophagic pathways: A potential key to Parkinson’s Disease pathogenesis
- (2014) Maria Xilouri et al. Autophagy
- A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy
- (2014) Randy Singh Atwal et al. Autophagy
- Altered macroautophagy in the spinal cord of SOD1 mutant mice
- (2014) Liang Li et al. Autophagy
- MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
- (2014) Xiaojie Zhang et al. Autophagy
- 1,25-Dyhydroxyvitamin D3 attenuates rotenone-induced neurotoxicity in SH-SY5Y cells through induction of autophagy
- (2014) Wooyoung Jang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson’s disease
- (2014) Karen E. Murphy et al. BRAIN
- Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
- (2014) Dun-Sheng Yang et al. BRAIN
- Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease
- (2014) Ludovic Collin et al. BRAIN
- Autophagy in cancer stem/progenitor cells
- (2014) Yi-Hui Lin et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition
- (2014) Michael A. Mandell et al. DEVELOPMENTAL CELL
- Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions
- (2014) Hedieh Shahpasandzadeh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
- (2014) Y. C. Wong et al. JOURNAL OF NEUROSCIENCE
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1
- (2014) Hannah C. Dooley et al. MOLECULAR CELL
- Oxidative Stress and Autophagic Alteration in Brainstem of SOD1-G93A Mouse Model of ALS
- (2014) Ting An et al. MOLECULAR NEUROBIOLOGY
- Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
- (2014) Virginie Buggia-Prévot et al. Molecular Neurodegeneration
- VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
- (2014) Emiko Miura et al. NEUROBIOLOGY OF DISEASE
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- (2014) J. A. Martina et al. Science Signaling
- Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52
- (2014) Chulman Jo et al. Nature Communications
- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
- (2014) Eszter Zavodszky et al. Nature Communications
- PICALM modulates autophagy activity and tau accumulation
- (2014) Kevin Moreau et al. Nature Communications
- Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
- (2014) Sandra Tenreiro et al. PLoS Genetics
- In vivo axonal transport deficits in a mouse model of fronto-temporal dementia
- (2014) Tabassum Majid et al. NeuroImage-Clinical
- Phosphorylation of serine 349 of p62 in Alzheimer’s disease brain
- (2014) Kunikazu Tanji et al. Acta Neuropathologica Communications
- Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer’s brains
- (2013) Kunie Ando et al. ACTA NEUROPATHOLOGICA
- Protein aggregation in amyotrophic lateral sclerosis
- (2013) Anna M. Blokhuis et al. ACTA NEUROPATHOLOGICA
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
- (2013) Karen Castillo et al. Autophagy
- Autophagy in stem cells
- (2013) Jun-Lin Guan et al. Autophagy
- Crosstalk between apoptosis, necrosis and autophagy
- (2013) Vassiliki Nikoletopoulou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
- (2013) Maria Xilouri et al. BRAIN
- SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status
- (2013) Yuewei Sheng et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
- (2013) Tian-Fang Jiang et al. Journal of Neuroimmune Pharmacology
- Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice
- (2013) Jing Du et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Induction of Autophagy by a Novel Small Molecule Improves Aβ Pathology and Ameliorates Cognitive Deficits
- (2013) Cheng Chu et al. PLoS One
- Polo-like kinase 2 regulates selective autophagic -synuclein clearance and suppresses its toxicity in vivo
- (2013) A. Oueslati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy
- (2013) Y. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- α-Synuclein oligomers and clinical implications for Parkinson disease
- (2012) Lorraine V. Kalia et al. ANNALS OF NEUROLOGY
- Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
- (2012) Véronique Schaeffer et al. BRAIN
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- The role of ALFY in selective autophagy
- (2012) P Isakson et al. CELL DEATH AND DIFFERENTIATION
- Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders
- (2012) Maria Xilouri et al. CNS & Neurological Disorders-Drug Targets
- Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
- (2012) Julia Romanov et al. EMBO JOURNAL
- Neuronal autophagy and neurodegenerative diseases
- (2012) Jin H. Son et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems
- (2012) Haiqun Jia et al. HUMAN MOLECULAR GENETICS
- TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
- (2012) Manohar Pilli et al. IMMUNITY
- ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex
- (2012) Endalkachew Ashenafi Alemu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
- (2012) I. Ahmed et al. JOURNAL OF NEUROSCIENCE
- Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of -Synuclein and LRRK2 in the Brain
- (2012) L. G. Friedman et al. JOURNAL OF NEUROSCIENCE
- Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome
- (2012) David A. Tumbarello et al. NATURE CELL BIOLOGY
- Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein
- (2012) Dan-Mei Lan et al. NEUROCHEMICAL RESEARCH
- The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
- (2012) Lin Qi et al. PLoS One
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chaperone-mediated autophagy: a unique way to enter the lysosome world
- (2012) Susmita Kaushik et al. TRENDS IN CELL BIOLOGY
- Autophagy and Neuronal Cell Death in Neurological Disorders
- (2012) R. A. Nixon et al. Cold Spring Harbor Perspectives in Biology
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
- (2011) Antje S. Löffler et al. Autophagy
- Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis
- (2011) Xiaojie Zhang et al. Autophagy
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
- (2011) Diego L. Medina et al. DEVELOPMENTAL CELL
- Microautophagy of Cytosolic Proteins by Late Endosomes
- (2011) Ranjit Sahu et al. DEVELOPMENTAL CELL
- CSPα knockout causes neurodegeneration by impairing SNAP-25 function
- (2011) Manu Sharma et al. EMBO JOURNAL
- A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway
- (2011) Yuan Tian et al. FASEB JOURNAL
- IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux
- (2011) Huikyong Lee et al. HUMAN MOLECULAR GENETICS
- Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
- (2011) Michela Palmieri et al. HUMAN MOLECULAR GENETICS
- Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism
- (2011) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis
- (2011) Shoichi Sasaki JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Pathological roles of α-synuclein in neurological disorders
- (2011) Kostas Vekrellis et al. LANCET NEUROLOGY
- Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
- (2011) Gen Matsumoto et al. MOLECULAR CELL
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
- (2011) Peter M. Andersen et al. Nature Reviews Neurology
- Clinical diagnosis and management of amyotrophic lateral sclerosis
- (2011) Orla Hardiman et al. Nature Reviews Neurology
- Neuronal Autophagy as a Mediator of Life and Death
- (2011) Julien Puyal et al. NEUROSCIENTIST
- Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
- (2011) Yuncheng Wu et al. NEUROSIGNALS
- Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits
- (2011) Smita Majumder et al. PLoS One
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- (2011) P. Wild et al. SCIENCE
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
- (2010) Gyungah Jun ARCHIVES OF NEUROLOGY
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- A comprehensive glossary of autophagy-related molecules and processes
- (2010) Daniel J. Klionsky et al. Autophagy
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- The Beclin 1 interactome
- (2010) Congcong He et al. CURRENT OPINION IN CELL BIOLOGY
- Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation
- (2010) Valérie Vingtdeux et al. FASEB JOURNAL
- Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
- (2010) C. Rose et al. HUMAN MOLECULAR GENETICS
- The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
- (2010) Valeria Crippa et al. HUMAN MOLECULAR GENETICS
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases
- (2010) Maurizio Renna et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97
- (2010) G. P. Ritson et al. JOURNAL OF NEUROSCIENCE
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
- (2010) Maria Filimonenko et al. MOLECULAR CELL
- Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
- (2010) Peter O Bauer et al. NATURE BIOTECHNOLOGY
- Autophagy in mammalian development and differentiation
- (2010) Noboru Mizushima et al. NATURE CELL BIOLOGY
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
- (2010) Jose A. Rodríguez-Navarro et al. NEUROBIOLOGY OF DISEASE
- Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
- (2010) Troy T. Rohn et al. NEUROBIOLOGY OF DISEASE
- Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
- (2010) Janel O. Johnson et al. NEURON
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice
- (2010) Shuqiu Zheng et al. PLoS Genetics
- Autophagy protects neuron from Aβ-induced cytotoxicity
- (2009) Shih-Ya Hung et al. Autophagy
- A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
- (2009) Carol A. Mercer et al. Autophagy
- Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
- (2009) Hyunkyung Jeong et al. CELL
- Autophagy in disease: a double-edged sword with therapeutic potential
- (2009) Wim Martinet et al. CLINICAL SCIENCE
- Molecular pathogenesis of Parkinson disease: insights from genetic studies
- (2009) Thomas Gasser EXPERT REVIEWS IN MOLECULAR MEDICINE
- XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
- (2009) C. Hetz et al. GENES & DEVELOPMENT
- Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
- (2009) Yipeng Wang et al. HUMAN MOLECULAR GENETICS
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
- (2009) Jozsef Gal et al. JOURNAL OF NEUROCHEMISTRY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
- (2009) Vladimir Kirkin et al. MOLECULAR CELL
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
- (2009) Teresa L M Thurston et al. NATURE IMMUNOLOGY
- Fifteen-year quest for microphthalmia-associated transcription factor target genes
- (2009) Yann Cheli et al. Pigment Cell & Melanoma Research
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
- (2009) Maria Xilouri et al. PLoS One
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
- (2009) Valerie Cullen et al. Molecular Brain
- Huntington's disease: from pathology and genetics to potential therapies
- (2008) Sara Imarisio et al. BIOCHEMICAL JOURNAL
- Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†
- (2008) Daniel Sevlever et al. BIOCHEMISTRY
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Mechanisms of neurodegeneration in Huntington’s disease
- (2008) Joana M. Gil et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Huntington’s disease: degradation of mutant huntingtin by autophagy
- (2008) Sovan Sarkar et al. FEBS Journal
- Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
- (2008) Tomohiro Kabuta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
- (2008) Fiona Pickford et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- (2008) Andrea Williams et al. Nature Chemical Biology
- Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
- (2008) H.-L. Feng et al. NEUROSCIENCE
- Lithium delays progression of amyotrophic lateral sclerosis
- (2008) F. Fornai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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