Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations
Published 2015 View Full Article
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Title
Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations
Authors
Keywords
Proteasomes, Hyperexpression techniques, Amyotrophic lateral sclerosis, Cell death, HeLa cells, Proteolysis, Transfection, Point mutation
Journal
PLoS One
Volume 10, Issue 6, Pages e0130162
Publisher
Public Library of Science (PLoS)
Online
2015-06-16
DOI
10.1371/journal.pone.0130162
References
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Related references
Note: Only part of the references are listed.- ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1
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- Ubiquilin-1 Overexpression Increases the Lifespan and Delays Accumulation of Huntingtin Aggregates in the R6/2 Mouse Model of Huntington's Disease
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- Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype
- (2012) Matthis Synofzik et al. NEUROBIOLOGY OF AGING
- Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death
- (2011) Janet Ugolino et al. HUMAN MOLECULAR GENETICS
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
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- Ubiquilin at a crossroads in protein degradation pathways
- (2010) Cara Rothenberg et al. Autophagy
- PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
- (2009) Elsa-Noah N'Diaye et al. EMBO REPORTS
- Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD
- (2009) Precious J. Lim et al. JOURNAL OF CELL BIOLOGY
- Herp enhances ER-associated protein degradation by recruiting ubiquilins
- (2008) Tae-Yeon Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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