Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

(2012) Meret Nora Gaugler et al.   ACTA NEUROPATHOLOGICA

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants

(2012) Mauro Salvi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

(2012) Vicente Sancenon et al.   HUMAN MOLECULAR GENETICS

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)

(2012) Onur Cizmecioglu et al.   JOURNAL OF CELL SCIENCE

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human  -Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

(2012) A. Oueslati et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

(2012) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

(2012) A L McCormack et al.   Cell Death & Disease

Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease

(2011) Jinxia Zhou et al.   ACTA NEUROPATHOLOGICA

Plk2 regulated centriole duplication is dependent on its localization to the centrosome and a functional polo-box domain

(2011) Onur Cizmecioglu et al.   CELL CYCLE

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes

(2011) Naomi P. Visanji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Authentically Phosphorylated  -Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease

(2011) H. Sato et al.   JOURNAL OF NEUROSCIENCE

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

(2011) Kea Joo Lee et al.   NEURON

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

Phosphorylated α-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

(2010) Youhei Machiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation

(2010) Danielle M Evers et al.   NATURE NEUROSCIENCE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication

(2010) Annekatrin Krause et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of α-synuclein in HEK293 cells

(2009) Masahiro Sakamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis

(2009) Kai-Yin Chau et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease

(2009) Nikolaus R. McFarland et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

(2009) Julien Dusonchet et al.   NEUROBIOLOGY OF DISEASE

Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice

(2009) H. Schell et al.   NEUROSCIENCE

Phosphorylation Does Not Prompt, Nor Prevent, the Formation of  -synuclein Toxic Species in a Rat Model of Parkinson's Disease

(2008) S. Azeredo da Silveira et al.   HUMAN MOLECULAR GENETICS

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

(2008) D. P. Seeburg et al.   JOURNAL OF NEUROSCIENCE

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity

(2008) Daniel P. Seeburg et al.   NEURON