Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions

PLK2 Modulates α-Synuclein Aggregation in Yeast and Mammalian Cells

(2013) Elisa Basso et al.   MOLECULAR NEUROBIOLOGY

SUMO and Parkinson’s Disease

(2013) Katrin Eckermann   NEUROMOLECULAR MEDICINE

In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain

(2013) M. Bergeron et al.   NEUROSCIENCE

Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

(2013) A. Oueslati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants

(2012) Mauro Salvi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sumoylation in neurodegenerative diseases

(2012) Petranka Krumova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context

(2012) Vicente Sancenon et al.   HUMAN MOLECULAR GENETICS

Aggregate Clearance of α-Synuclein inSaccharomyces cerevisiaeDepends More on Autophagosome and Vacuole Function Than on the Proteasome

(2012) Doris Petroi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

(2012) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses

(2011) Qi Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokine-induced Paracrystals Prolong the Activity of Signal Transducers and Activators of Transcription (STAT) and Provide a Model for the Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO)

(2011) Mathias Droescher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein fate is determined by USP9X-regulated monoubiquitination

(2011) R. Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Wss1 Is a SUMO-Dependent Isopeptidase That Interacts Genetically with the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase

(2010) J. R. Mullen et al.   MOLECULAR AND CELLULAR BIOLOGY

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of α-synuclein in HEK293 cells

(2009) Masahiro Sakamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Yeast unfolds the road map toward α-synuclein-induced cell death

(2009) V Franssens et al.   CELL DEATH AND DIFFERENTIATION

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

(2009) Alexandre Janer et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Ubiquitin-like Modifier (SUMO) Modification of the Androgen Receptor Attenuates Polyglutamine-mediated Aggregation

(2009) Sarmistha Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein S129 Phosphorylation Mutants Do Not Alter Nigrostriatal Toxicity in a Rat Model of Parkinson Disease

(2009) Nikolaus R. McFarland et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phosphorylation Does Not Prompt, Nor Prevent, the Formation of  -synuclein Toxic Species in a Rat Model of Parkinson's Disease

(2008) S. Azeredo da Silveira et al.   HUMAN MOLECULAR GENETICS

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein

(2008) Elisa A. Waxman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The phosphorylation state of Ser-129 in human  -synuclein determines neurodegeneration in a rat model of Parkinson disease

(2008) O. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA