Geniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway

TCF7L2 is a master regulator of insulin production and processing

(2014) Yuedan Zhou et al.   HUMAN MOLECULAR GENETICS

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

(2013) Cassandra Koole et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

(2013) Mark I. McCarthy et al.   Cell Metabolism

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

(2012) L. Shu et al.   DIABETOLOGIA

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets indb/dbmice

(2012) Gyeong-Min Do et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis

(2012) Jianhui Liu et al.   TOXICOLOGY IN VITRO

Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

(2011) Li-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

FTY720 Normalizes Hyperglycemia by Stimulating β-Cellin VivoRegeneration indb/dbMice through Regulation of Cyclin D3 and p57KIP2

(2011) Zhengshan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Cell-protective effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice

(2011) Seung Jin Han et al.   JOURNAL OF ENDOCRINOLOGY

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Blockade of JAK2 activity suppressed accumulation of β-catenin in leukemic cells

(2010) Ya-Chen Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transforming growth factor-β induces epithelial to mesenchymal transition and suppresses the proliferation and transdifferentiation of cultured human pancreatic duct cells

(2010) Jeong-Ah Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cdk4 Regulates Recruitment of Quiescent β-Cells and Ductal Epithelial Progenitors to Reconstitute β-Cell Mass

(2010) Ji-Hyeon Lee et al.   PLoS One

Beta cell regeneration in human pancreas

(2010) Roberto Gianani   Seminars in Immunopathology

β-Cell regeneration: the pancreatic intrinsic faculty

(2010) Renaud Desgraz et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin

(2009) Shao-yu Wu et al.   ACTA PHARMACOLOGICA SINICA

Neonatal growth and regeneration of β-cells are regulated by the Wnt/β-catenin signaling in normal and diabetic rats

(2009) Florence Figeac et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emerging therapies for metabolic diseases—the focus is on diabetes and obesity

(2009) Thomas E Hughes   CURRENT OPINION IN CHEMICAL BIOLOGY

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Mechanisms of KGF Mediated Signaling in Pancreatic Duct Cell Proliferation and Differentiation

(2009) Benjamin Uzan et al.   PLoS One

β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma

(2008) Shuang Yan et al.   CANCER LETTERS

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus

(2008) Tianru Jin et al.   MOLECULAR ENDOCRINOLOGY

Wnt signaling: relevance to β-cell biology and diabetes

(2008) Hannah J. Welters et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM