Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer

(2018) Karen K. L. Chan et al.   Cancer Cell International

Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy

(2018) Xiao-Yan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

(2018) Huiling Lai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?

(2018) Lynn Roy et al.   Cancers

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation

(2018) Lok Hei Chan et al.   Cell Reports

Cancer Associated Fibroblasts: Naughty Neighbors That Drive Ovarian Cancer Progression

(2018) Subramanyam Dasari et al.   Cancers

Biological Pathways Involved in Tumor Angiogenesis and Bevacizumab Based Anti-Angiogenic Therapy with Special References to Ovarian Cancer

(2017) Vera Loizzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the tumour microenvironment in ovarian cancer

(2016) Jean M. Hansen et al.   EUROPEAN JOURNAL OF CANCER

Focal Adhesion Kinase and Wnt Signaling Regulate Human Ductal Carcinoma In Situ Stem Cell Activity and Response to Radiotherapy

(2015) Kathryn E. Williams et al.   STEM CELLS

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

(2015) Sang-A Park et al.   Scientific Reports

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

(2015) Ravi Thakur et al.   Scientific Reports

Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells

(2015) Abir Mukherjee et al.   NEOPLASIA

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulators in ovarian cancer

(2014) Karen Kar-Loen Chan et al.   JOURNAL OF ENDOCRINOLOGY

β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids

(2014) S Condello et al.   ONCOGENE

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

(2014) I. M. Shapiro et al.   Science Translational Medicine

Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition

(2013) Benoît Thibault et al.   CANCER AND METASTASIS REVIEWS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

(2013) Elizabeth J. Sullivan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer

(2013) J. M. Balko et al.   CANCER RESEARCH

Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration

(2012) Christine A. Caneba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A novel miR-155/miR-143 cascade controls glycolysis by regulatinghexokinase 2in breast cancer cells

(2012) Shuai Jiang et al.   EMBO JOURNAL

Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 study

(2012) John Farley et al.   LANCET ONCOLOGY

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers

(2012) M K Y Siu et al.   ONCOGENE

Expression of urokinase plasminogen activator and plasminogen activator inhibitor type-1 in ovarian cancer and its clinical significance

(2012) WEI ZHANG et al.   ONCOLOGY REPORTS

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

(2011) Kristina Goetze   INTERNATIONAL JOURNAL OF ONCOLOGY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Identification of Metabolites in the Normal Ovary and Their Transformation in Primary and Metastatic Ovarian Cancer

(2011) Miranda Y. Fong et al.   PLoS One

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-  and integrin/focal adhesion kinase (FAK) signaling

(2011) M. Schober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis

(2010) H. A. Kenny et al.   CLINICAL CANCER RESEARCH

CADPE Inhibits PMA-Stimulated Gastric Carcinoma Cell Invasion and Matrix Metalloproteinase-9 Expression by FAK/MEK/ERK-Mediated AP-1 Activation

(2010) H. Han et al.   MOLECULAR CANCER RESEARCH

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

(2010) M. K. Y. Siu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH