The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway

Inhibition of Bruton’s Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer’s Disease

(2019) James Keaney et al.   Journal of Neuroimmune Pharmacology

Activation of NF-κB in B cell receptor signaling through Bruton’s tyrosine kinase-dependent phosphorylation of IκB-α

(2019) Marilena Pontoriero et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis

(2018) Amelia Bercusson et al.   BLOOD

Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice

(2018) J. Hu et al.   BRITISH JOURNAL OF ANAESTHESIA

Inhibitor of Bruton's tyrosine kinases, PCI-32765, decreases pro-inflammatory mediators' production in high glucose-induced macrophages

(2018) Zhe Fan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Different effects of immune stimulation on chronic unpredictable mild stress-induced anxiety- and depression-like behaviors depending on timing of stimulation

(2018) Jiangyan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide improves hepatic inflammation in diabetic db/db mice

(2018) Xiaolei Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes

(2018) Dong Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Blood-Brain Barrier Disruption Induced Cognitive Impairment Is Associated With Increase of Inflammatory Cytokine

(2018) Jieli Geng et al.   Frontiers in Aging Neuroscience

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice

(2018) Hye Yeon Nam et al.   Journal of Neuroinflammation

TLR7 (Toll-Like Receptor 7) Facilitates Heme Scavenging Through the BTK (Bruton Tyrosine Kinase)–CRT (Calreticulin)–LRP1 (Low-Density Lipoprotein Receptor–Related Protein-1)–Hx (Hemopexin) Pathway in Murine Intracerebral Hemorrhage

(2018) Gaiqing Wang et al.   STROKE

Inhibition of BTK protects lungs from trauma-hemorrhagic shock-induced injury in rats

(2017) Xinwei Liu et al.   Molecular Medicine Reports

Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses

(2017) Chi-Ho Lee et al.   MOLECULAR NEUROBIOLOGY

FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice

(2017) Qingzhi Wang et al.   MOLECULAR NEUROBIOLOGY

Preface for the Mary C. McKenna Honorary Issue of Neurochemical Research

(2017) Arne Schousboe   NEUROCHEMICAL RESEARCH

Geniposide ameliorates cognitive deficits by attenuating the cholinergic defect and amyloidosis in middle-aged Alzheimer model mice

(2017) Chunhui Zhao et al.   NEUROPHARMACOLOGY

Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats

(2017) Chunyu Ma et al.   PHARMACEUTICAL BIOLOGY

Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling

(2016) Cristina Lao-Peregrín et al.   ADDICTION BIOLOGY

Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways

(2016) Xiaolei Hu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells

(2016) Fanghe Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice

(2016) Junming Wang et al.   METABOLIC BRAIN DISEASE

Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice

(2016) Chun Teng Zhang et al.   NEUROTOXICOLOGY

Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde

(2016) Akshay Jawale et al.   PHYTOMEDICINE

Insulin resistance and Parkinson’s disease: A new target for disease modification?

(2016) D. Athauda et al.   PROGRESS IN NEUROBIOLOGY

Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway

(2016) Chunhui Zhao et al.   PLoS One

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

(2015) Zhujun Yin et al.   BEHAVIOURAL BRAIN RESEARCH

Bruton’s Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice

(2015) James B. Case et al.   JOURNAL OF IMMUNOLOGY

Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats

(2015) Xianchu Liu et al.   METABOLIC BRAIN DISEASE

Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages

(2015) Chisato Sakuma et al.   MOLECULAR IMMUNOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106

(2014) Rehan Zafar Paracha et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Geniposide Ameliorates Learning Memory Deficits, Reduces Tau Phosphorylation and Decreases Apoptosis via GSK3β Pathway in Streptozotocin-Induced Alzheimer Rat Model

(2013) Chong Gao et al.   BRAIN PATHOLOGY

Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis

(2012) Jianhui Liu et al.   TOXICOLOGY IN VITRO

Psychological and quality of life changes in patients using GLP-1 analogues

(2011) Paul Grant et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Reduced Diabetes in btk-Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-Insulin IgH Chain Transgene

(2009) P. L. Kendall et al.   JOURNAL OF IMMUNOLOGY