Unfolded protein response is involved in geniposide-regulating glucose-stimulated insulin secretion in INS-1 cells

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

(2018) Carrie R. Sowers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of proinsulin misfolding on β-cell dynamics, differentiation and function in diabetes

(2018) Yael Riahi et al.   DIABETES OBESITY & METABOLISM

Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells

(2017) L.X. Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Unfolded protein response: Pro-survival clock sUPRession

(2017) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

5′-AMP-activated protein kinase plays an essential role in geniposide-regulated glucose-stimulated insulin secretion in rat pancreatic INS-1 β cells

(2016) Yanan Hao et al.   Journal of Natural Medicines

Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells

(2016) C. Y. Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes

(2015) Esperanza Irles et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Thioredoxin-Interacting Protein Stimulates Its Own Expression via a Positive Feedback Loop

(2014) Junqin Chen et al.   MOLECULAR ENDOCRINOLOGY

Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes

(2013) Mitsuhiro Okamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrating insulin secretion and ER stress in pancreatic β-cells

(2012) Katleen Lemaire et al.   NATURE CELL BIOLOGY

Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis

(2012) Jianhui Liu et al.   TOXICOLOGY IN VITRO

Glucagon-like peptide 1 receptor plays a critical role in geniposide-regulated insulin secretion in INS-1 cells

(2011) Li-xia Guo et al.   ACTA PHARMACOLOGICA SINICA

ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells

(2011) June Woo Lee et al.   MOLECULES AND CELLS

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

(2010) W. A. Chutkow et al.   DIABETES

PERK in beta cell biology and insulin biogenesis

(2010) Douglas R. Cavener et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein

(2009) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of TXNIP protects β-cells against glucotoxicity: Figure 1

(2008) Anath Shalev   BIOCHEMICAL SOCIETY TRANSACTIONS

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

(2008) Junqin Chen et al.   FASEB JOURNAL

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY