Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β42 in Neuron-Microglia Co-Culture Models

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration

(2018) Claudia Saraceno et al.   JOURNAL OF ALZHEIMERS DISEASE

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

Pro-resolving mediator maresin 1 ameliorates pain hypersensitivity in a rat spinal nerve ligation model of neuropathic pain

(2018) Jie Gao et al.   Journal of Pain Research

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

(2018) T. Yang et al.   BRITISH JOURNAL OF ANAESTHESIA

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

Gene networks in neurodegenerative disorders

(2017) Daniela Recabarren et al.   LIFE SCIENCES

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

(2017) Jong Kil Lee et al.   MOLECULES

Endothelin-1 Induces Degeneration of Cultured Motor Neurons Through a Mechanism Mediated by Nitric Oxide and PI3K/Akt Pathway

(2017) S. D’Antoni et al.   NEUROTOXICITY RESEARCH

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

(2017) Jesmond Dalli et al.   Frontiers in Immunology

Amyloid-β Peptides Stimulate the Expression of the p75NTR Neurotrophin Receptor in SHSY5Y Human Neuroblastoma Cells and AD Transgenic Mice

(2017) Balu Chakravarthy et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D -galactose/AlCl 3 inducing rats model of Alzheimer’s disease

(2016) Hongyan Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

The rise and fall of insulin signaling in Alzheimer’s disease

(2016) B. Chami et al.   METABOLIC BRAIN DISEASE

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

(2016) YUJIE WANG et al.   Molecular Medicine Reports

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid

(2015) Komal Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

Human milk proresolving mediators stimulate resolution of acute inflammation

(2015) H Arnardottir et al.   Mucosal Immunology

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

(2015) Levi B. Wood et al.   Scientific Reports

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

p38 MAPK: A Potential Target of Chronic Pain

(2014) X. Lin et al.   CURRENT MEDICINAL CHEMISTRY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

The roles of protein kinases in learning and memory

(2013) K. P. Giese et al.   LEARNING & MEMORY

7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1

(2013) Ki Cheon Kim et al.   Biomed Research International

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Caspase-3 activation as a bifurcation point between plasticity and cell death

(2012) Shikha Snigdha et al.   Neuroscience Bulletin

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

(2011) Shi Zhang et al.   Journal of Neuroinflammation

p75NTR Regulates A  Deposition by Increasing A  Production But Inhibiting A  Aggregation with Its Extracellular Domain

(2011) Y.-J. Wang et al.   JOURNAL OF NEUROSCIENCE

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Soluble βamyloid1-42: a critical player in producing behavioural and biochemical changes evoking depressive-related state?

(2010) M Colaianna et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

ERK in Learning and Memory: A Review of Recent Research

(2010) Sheng Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The p38 mitogen-activated protein kinase pathway—A potential target for intervention in infarction, hypertrophy, and heart failure

(2010) Michael S. Marber et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neurodegeneration and the neuroimmune system

(2010) Joseph El Khoury   NATURE MEDICINE

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Involvement of phosphoinositide 3-kinase γ in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1–40 peptide in mice

(2009) Giselle F. Passos et al.   BRAIN BEHAVIOR AND IMMUNITY

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

(2009) Nathalie Koning et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

p75NTR Antagonistic Cyclic Peptide Decreases the Size of β Amyloid-Induced Brain Inflammation

(2008) Mina Yaar et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY