Nrf2 Activation Protects Mouse Beta Cells from Glucolipotoxicity by Restoring Mitochondrial Function and Physiological Redox Balance

Glucose Acutely Reduces Cytosolic and Mitochondrial H2O2 in Rat Pancreatic Beta Cells

(2018) Jean-Philippe Deglasse et al.   ANTIOXIDANTS & REDOX SIGNALING

Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2/ARE pathway in vitro and in vivo

(2018) Chen-guang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

(2017) Chethan Sampath et al.   FOOD CHEMISTRY

Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells

(2017) Morgana Barroso Oquendo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

(2017) Joshua A. David et al.   Journal of Diabetes Research

Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor

(2017) Nicolai M. Doliba et al.   Molecular Metabolism

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Real-time imaging of intracellular hydrogen peroxide in pancreatic islets

(2016) A. Neal et al.   BIOCHEMICAL JOURNAL

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway

(2016) Daniel A Cunha et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of Periostin Prevents High Glucose-Induced Mitochondrial Apoptosis in Human Umbilical Vein Endothelial Cells via Activation of Nrf2/HO-1 Signaling

(2016) Zhi-ying Zhong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells

(2015) Armin Edalat et al.   DIABETOLOGIA

Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreaticβ-Cell Damage

(2015) Jingqi Fu et al.   Oxidative Medicine and Cellular Longevity

The Effect of Nrf2 Pathway Activation on Human Pancreatic Islet Cells

(2015) Yuichi Masuda et al.   PLoS One

Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes

(2014) Y. J. Lee et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

(2014) Wenjuan Li et al.   FEBS LETTERS

TCF2 Attenuates FFA-Induced Damage in Islet β-Cells by Regulating Production of Insulin and ROS

(2014) Xiaojuan Quan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

(2013) Baggavalli P Somesh et al.   BMC CELL BIOLOGY

Nrf2 Protects Pancreatic  -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice

(2013) Y. Yagishita et al.   DIABETES

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of the Saturated Nonesterified Fatty Acid Palmitate in Beta Cell Dysfunction

(2012) Michael Maris et al.   JOURNAL OF PROTEOME RESEARCH

Redox Homeostasis in Pancreatic Cells

(2012) Petr Ježek et al.   Oxidative Medicine and Cellular Longevity

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets

(2011) Maria Fernanda Graciano et al.   Islets

Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate

(2011) Gyeong Ryul Ryu et al.   Diabetes & Metabolism Journal

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Low-Level Arsenic Impairs Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells: Involvement of Cellular Adaptive Response to Oxidative Stress

(2010) Jingqi Fu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Oxidative stress and beta-cell dysfunction

(2010) Gisela Drews et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

(2009) Jingbo Pi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES