Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Geniposide Suppresses Interleukin-1β-Induced Inflammation and Apoptosis in Rat Chondrocytes via the PI3K/Akt/NF-κB Signaling Pathway

(2017) Tianlong Pan et al.   INFLAMMATION

Anti-inflammatory mechanism of ulinastatin: Inhibiting the hyperpermeability of vascular endothelial cells induced by TNF-α via the RhoA/ROCK signal pathway

(2017) Fu Wei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint

(2017) Seiji Yokota et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis

(2017) Yong Tan et al.   MEDIATORS OF INFLAMMATION

NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis

(2017) Ya-ru Liu et al.   MOLECULAR IMMUNOLOGY

Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

(2017) Rong Wang et al.   PHYTOTHERAPY RESEARCH

Immune Tolerance Effect in Mesenteric Lymph Node Lymphocytes of Geniposide on Adjuvant Arthritis Rats

(2017) Zheng-Rong Zhang et al.   PHYTOTHERAPY RESEARCH

IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy

(2017) Eun Kyung Kim et al.   Cell Death & Disease

EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway

(2017) Ruolan Dong et al.   Oncotarget

Dasatinib inhibits actin fiber reorganization and promotes endothelial cell permeability through RhoA-ROCK pathway

(2017) Swapan K. Dasgupta et al.   Cancer Medicine

Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-κB Activation

(2017) Yuanyuan Zhuang et al.   Frontiers in Pharmacology

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK

(2017) Yawen Ni et al.   PLoS One

Effect of Qianghuo Erhuang Decoction on T Regulatory and T Helper 17 Cells in Treatment of Adjuvant-induced Arthritis in Rats

(2017) Can Qian et al.   Scientific Reports

Sinomenine alleviates high glucose-induced renal glomerular endothelial hyperpermeability by inhibiting the activation of RhoA/ROCK signaling pathway

(2016) Qingqiao Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine induces dedifferentiation by actin cytoskeleton reorganization via phosphoinositide 3-kinase/Akt and p38 kinase pathways in rabbit articular chondrocytes

(2016) Seon-Mi Yu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy

(2016) Finny Monickaraj et al.   FASEB JOURNAL

Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFкB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats

(2016) Ramamoorthi Ganesan et al.   IMMUNOLOGIC RESEARCH

Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

(2016) Qing-Zhu Kong et al.   MEDIATORS OF INFLAMMATION

β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase

(2016) Shibo Zou et al.   Pharmacological Reports

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

(2015) Roba M. Talaat et al.   CYTOKINE

Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin fromNaja naja atra

(2015) Cao-Xin Chen et al.   Evidence-based Complementary and Alternative Medicine

Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated autoimmune arthritis

(2015) Yan Chang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interferon-Gamma Increases Endothelial Permeability by Causing Activation of p38 MAP Kinase and Actin Cytoskeleton Alteration

(2015) Chin Theng Ng et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Determination of geniposide in adjuvant arthritis rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry method and its application to oral bioavailability and plasma protein binding ability studies

(2015) Jian Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor- 1 toward Fibroblast-like Synovial Cells

(2015) T. Suzuki et al.   JOURNAL OF RHEUMATOLOGY

The impact of biological therapy on regulatory T cells in rheumatoid arthritis

(2015) R. Byng-Maddick et al.   RHEUMATOLOGY

Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus

(2015) Guang Fu Dong et al.   Journal of Immunology Research

Role of T Lymphocytes in the Development of Rheumatoid Arthritis. Implications for Treatment

(2014) Erik Lubberts   CURRENT PHARMACEUTICAL DESIGN

Effects and mechanisms of Geniposide on rats with adjuvant arthritis

(2014) Miao-Miao Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

p38MAPK, Rho/ROCK and PKC pathways are involved in influenza-induced cytoskeletal rearrangement and hyperpermeability in PMVEC via phosphorylating ERM

(2014) Chenyue Zhang et al.   VIRUS RESEARCH

NADPH Oxidase Complex-Derived Reactive Oxygen Species, the Actin Cytoskeleton, and Rho GTPases in Cell Migration

(2013) Alanna Stanley et al.   ANTIOXIDANTS & REDOX SIGNALING

Brief Report: Association of Genetic Variants in theIL4andIL4RGenes With the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts

(2013) A. Krabben et al.   ARTHRITIS AND RHEUMATISM

A meta-analysis of the role of p38 mitogen-activated protein kinase inhibitors in patients with active rheumatoid arthritis

(2013) Lan Li et al.   CLINICAL RHEUMATOLOGY

The fibroblast as a therapeutic target in rheumatoid arthritis

(2013) Andrew Filer   CURRENT OPINION IN PHARMACOLOGY

Sex- and age-specific incidence of autoimmune rheumatic diseases in the Chinese population: A Taiwan population-based study

(2013) Lai-Chu See et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Alternative p38 MAPKs Are Essential for Collagen-Induced Arthritis

(2013) Gabriel Criado et al.   Arthritis & Rheumatology

RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response

(2012) Jiping Wang et al.   Cardiovascular Diabetology

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

(2012) Aron Chakera et al.   Clinical & Developmental Immunology

Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models

(2012) Yunhe Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Geniposide, an Iridoid Glucoside Derived fromGardenia jasminoides, Protects against Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2012) Yang Xiaofeng et al.   PLANTA MEDICA

Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA

(2012) Youjun Xiao et al.   RHEUMATOLOGY INTERNATIONAL

Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis

(2011) M. Connolly et al.   ANNALS OF THE RHEUMATIC DISEASES

Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells

(2011) Daiji Kawanami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY