Who’s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond

Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

(2021) Haoxi Wu et al.   DEVELOPMENTAL CELL

An Arf/Rab cascade controls the growth and invasiveness of glioblastoma

(2021) Gopinath Kulasekaran et al.   JOURNAL OF CELL BIOLOGY

Membrane Protein Quality Control Mechanisms in the Endo-Lysosome System

(2021) Richa Sardana et al.   TRENDS IN CELL BIOLOGY

Mechanisms of nonvesicular lipid transport

(2021) Karin M. Reinisch et al.   JOURNAL OF CELL BIOLOGY

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

(2021) Shirley Tremel et al.   Nature Communications

De novo formation of early endosomes during Rab5 to Rab7 transition

(2021) Frode Miltzow Skjeldal et al.   JOURNAL OF CELL SCIENCE

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly

(2021) Natalya Leneva et al.   Science Advances

Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1

(2021) Antonio Galindo et al.   EMBO JOURNAL

Structural basis of TRAPPIII‐mediated Rab1 activation

(2021) Aaron MN Joiner et al.   EMBO JOURNAL

SKIP ‐ HOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport

(2020) Marlieke LM Jongsma et al.   EMBO JOURNAL

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stochastic activation and bistability in a Rab GTPase regulatory network

(2020) Urban Bezeljak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved and regulated mechanism drives endosomal Rab transition

(2020) Lars Langemeyer et al.   eLife

Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

(2020) Amy H. Ponsford et al.   Autophagy

The Lysosome at the Intersection of Cellular Growth and Destruction

(2020) Hijai R. Shin et al.   DEVELOPMENTAL CELL

A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function

(2020) Lena Dehnen et al.   JOURNAL OF CELL SCIENCE

A non-linear system patterns Rab5 GTPase on the membrane

(2020) Alice Cezanne et al.   eLife

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Rab5-dependent autophagosome closure by ESCRT

(2019) Fan Zhou et al.   JOURNAL OF CELL BIOLOGY

ARF GTPases and their GEFs and GAPs: concepts and challenges

(2019) Elizabeth Sztul et al.   MOLECULAR BIOLOGY OF THE CELL

The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases

(2019) Shanna L. Bowman et al.   TRAFFIC

Structure of membrane tethers and their role in fusion

(2019) Christian Ungermann et al.   TRAFFIC

Correlative single-molecule localization microscopy and electron tomography reveals endosome nanoscale domains

(2019) Christian Franke et al.   TRAFFIC

Ypt/Rab GTPases and their TRAPP GEFs at the Golgi

(2019) Zhanna Lipatova et al.   FEBS LETTERS

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

(2019) Arunas Kvainickas et al.   JOURNAL OF CELL BIOLOGY

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Budding Yeast Has a Minimal Endomembrane System

(2018) Kasey J. Day et al.   DEVELOPMENTAL CELL

Mechanisms of lysosomal positioning and movement

(2018) Birol Cabukusta et al.   TRAFFIC

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

(2018) Jieqiong Gao et al.   eLife

Endosomal Rab cycles regulate Parkin-mediated mitophagy

(2018) Koji Yamano et al.   eLife

A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles

(2018) Jieqiong Gao et al.   JOURNAL OF CELL BIOLOGY

TBC1D5 controls the GTPase cycle of Rab7b

(2018) Marita Borg Distefano et al.   JOURNAL OF CELL SCIENCE

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography

(2018) Oleksiy Kovtun et al.   NATURE

Endosomal trafficking of yeast membrane proteins

(2018) Kamilla M. E. Laidlaw et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endosomal Sorting: Architecture of the Retromer Coat

(2018) Boris Simonetti et al.   CURRENT BIOLOGY

A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF

(2018) Laura L. Thomas et al.   DEVELOPMENTAL CELL

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies

(2018) Yoshihiko Kuchitsu et al.   Cells

A guanine nucleotide exchange factor (GEF) limits Rab GTPase–driven membrane fusion

(2017) Lars Langemeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide conversion in endocytosis and the endolysosomal system

(2017) Alexander Wallroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases

(2017) Falko Riedel et al.   JOURNAL OF CELL BIOLOGY

The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway

(2017) Laura L. Thomas et al.   JOURNAL OF CELL BIOLOGY

Rab2 promotes autophagic and endocytic lysosomal degradation

(2017) Péter Lőrincz et al.   JOURNAL OF CELL BIOLOGY

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes

(2017) Rituraj Marwaha et al.   JOURNAL OF CELL BIOLOGY

The VPS34 PI3K negatively regulates RAB-5 during endosome maturation

(2017) Fiona Law et al.   JOURNAL OF CELL SCIENCE

Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux

(2017) Laura Pontano Vaites et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments

(2017) Margaret A. Gustafson et al.   MOLECULAR BIOLOGY OF THE CELL

A cascade of multiple proteins and lipids catalyzes membrane fusion

(2017) William Wickner et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

(2017) Stephan Kiontke et al.   Nature Communications

A Rab5 GTPase module is important for autophagosome closure

(2017) Fan Zhou et al.   PLoS Genetics

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

(2017) Naonobu Fujita et al.   eLife

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis

(2016) Laura L. Thomas et al.   JOURNAL OF CELL BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

(2016) Danièle Stalder et al.   MOLECULAR BIOLOGY OF THE CELL

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

Spatiotemporal Resolution of Rab9 and CI-MPR Dynamics in the Endocytic Pathway

(2016) Ana Kucera et al.   TRAFFIC

Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond

(2016) Kerstin Klinkert et al.   TRAFFIC

The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase

(2016) Brian C Richardson et al.   eLife

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy

(2015) J. Xu et al.   EMBO REPORTS

Phosphorylation-dependent Regulation of Connecdenn/DENND1 Guanine Nucleotide Exchange Factors

(2015) Gopinath Kulasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

(2015) Rik van der Kant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells

(2015) Sayaka Yasuda et al.   JOURNAL OF CELL SCIENCE

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

(2015) D. Khatter et al.   JOURNAL OF CELL SCIENCE

Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation

(2015) S. Ka lin et al.   JOURNAL OF CELL SCIENCE

Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes

(2015) Bjorn D. M. Bean et al.   MOLECULAR BIOLOGY OF THE CELL

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum

(2015) Ying Li et al.   Scientific Reports

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Protein Delivery to Vacuole Requires SAND Protein-Dependent Rab GTPase Conversion for MVB-Vacuole Fusion

(2014) Manoj K. Singh et al.   CURRENT BIOLOGY

Four GTPases Differentially Regulate the Sec7 Arf-GEF to Direct Traffic at the trans-Golgi Network

(2014) Caitlin M. McDonold et al.   DEVELOPMENTAL CELL

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion

(2014) T. A. M. Bharat et al.   EMBO REPORTS

Quality control at the plasma membrane: One mechanism does not fit all

(2014) Markus Babst   JOURNAL OF CELL BIOLOGY

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes

(2014) M. Cabrera et al.   JOURNAL OF CELL SCIENCE

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature

(2014) Yading Ling et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3

(2014) Gus Lawrence et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis

(2014) Y. Cui et al.   PLANT CELL

Rab5 Isoforms Orchestrate a “Division of Labor” in the Endocytic Network; Rab5C Modulates Rac-Mediated Cell Motility

(2014) Pin-I Chen et al.   PLoS One

Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling

(2014) Juanfei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

(2014) Enrico D. Perini et al.   TRAFFIC

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

(2014) Zhe Zhang et al.   eLife

Guanine Nucleotide Exchange Factors (GEFs) Have a Critical but Not Exclusive Role in Organelle Localization of Rab GTPases

(2013) Margarita Cabrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RabGEFs are a major determinant for specific Rab membrane targeting

(2013) Julia Blümer et al.   JOURNAL OF CELL BIOLOGY

Rab GTPases and membrane identity: Causal or inconsequential?

(2013) Francis A. Barr   JOURNAL OF CELL BIOLOGY

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

(2013) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners

(2013) D. Stalder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor

(2012) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

The Sec7 Arf-GEF Is Recruited to the trans-Golgi Network by Positive Feedback

(2012) Brian C. Richardson et al.   DEVELOPMENTAL CELL

Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells

(2012) Andrea Linford et al.   DEVELOPMENTAL CELL

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release

(2012) Jörg Malsam et al.   EMBO JOURNAL

Rab5 Proteins Regulate Activation and Localization of Target of Rapamycin Complex 1

(2012) Dave Bridges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration

(2012) P. D. Allaire et al.   JOURNAL OF CELL SCIENCE

Rab11 regulates exocytosis of recycling vesicles at the plasma membrane

(2012) Senye Takahashi et al.   JOURNAL OF CELL SCIENCE

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation

(2012) Ting-Ting Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes

(2012) B. Sot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p

(2010) Emi Mizuno-Yamasaki et al.   DEVELOPMENTAL CELL

Rab7b controls trafficking from endosomes to the TGN

(2010) C. Progida et al.   JOURNAL OF CELL SCIENCE

The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome

(2010) Henning J. kleine Balderhaar et al.   JOURNAL OF CELL SCIENCE

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

Coordination of Rab8 and Rab11 in primary ciliogenesis

(2010) A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab5 Isoforms Differentially Regulate the Trafficking and Degradation of Epidermal Growth Factor Receptors

(2009) Pin-I Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Lipid Requirements for SNARE- and SNARE Chaperone-dependent Membrane Fusion

(2009) Joji Mima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

RabGDI Displacement by DrrA from Legionella Is a Consequence of Its Guanine Nucleotide Exchange Activity

(2009) Stefan Schoebel et al.   MOLECULAR CELL

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein

(2008) Miyuki Sato et al.   EMBO JOURNAL

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

(2008) Tim Bergbrede et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

(2008) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Membrane identity and GTPase cascades regulated by toggle and cut-out switches

(2008) Perla Del Conte-Zerial et al.   Molecular Systems Biology