Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release

Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

(2012) Jae-Yeol Kim et al.   EMBO JOURNAL

Phosphatidylinositol 4,5-Bisphosphate Increases Ca2+Affinity of Synaptotagmin-1 by 40-fold

(2012) Geert van den Bogaart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Alters Synaptotagmin 1 Membrane Docking and Drives Opposing Bilayers Closer Together

(2011) Weiwei Kuo et al.   BIOCHEMISTRY

Complexin Maintains Vesicles in the Primed State in C. elegans

(2011) Robert J. Hobson et al.   CURRENT BIOLOGY

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

(2011) Zhao Wang et al.   JOURNAL OF CELL BIOLOGY

Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle Fusion In Vivo

(2011) B. E. Paddock et al.   JOURNAL OF NEUROSCIENCE

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

(2011) Feng Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

(2011) M. Kyoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modification of Cognitive Performance in Schizophrenia by Complexin 2 Gene Polymorphisms

(2010) Martin Begemann et al.   ARCHIVES OF GENERAL PSYCHIATRY

Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix

(2010) Xiaofei Yang et al.   NEURON

A fast, single-vesicle fusion assay mimics physiological SNARE requirements

(2010) Erdem Karatekin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Ca2+-Dependent Stimulation of Vesicle Fusion by Membrane-Anchored Synaptotagmin 1

(2010) H. K. Lee et al.   SCIENCE

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

A role of complexin-lipid interactions in membrane fusion

(2009) Florian Seiler et al.   FEBS LETTERS

Tilting the Balance between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis

(2009) Mingshan Xue et al.   NEURON

The carboxy-terminal domain of complexin I stimulates liposome fusion

(2009) Jörg Malsam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion

(2009) C. G. Giraudo et al.   SCIENCE

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

How Does Synaptotagmin Trigger Neurotransmitter Release?

(2008) Edwin R. Chapman   Annual Review of Biochemistry

Synaptotagmin Perturbs the Structure of Phospholipid Bilayers†

(2008) Victor Shahin et al.   BIOCHEMISTRY

Membrane traffic in the secretory pathway

(2008) J. Malsam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Distinct Domains of Complexins Bind SNARE Complexes and Clamp Fusionin Vitro

(2008) Claudio G. Giraudo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotagmin C2B Domain Regulates Ca2+-triggered Fusionin Vitro

(2008) Jon D. Gaffaney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

(2008) Michael C Chicka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptic vesicle fusion

(2008) Josep Rizo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin and Ca2+ stimulate SNARE-mediated membrane fusion

(2008) Tae-Young Yoon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming

(2008) H. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system

(2008) M. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

(2004) Yuan Cheng et al.   PROTEIN SCIENCE