A guanine nucleotide exchange factor (GEF) limits Rab GTPase–driven membrane fusion

Multivalent Rab interactions determine tether-mediated membrane fusion

(2017) Anna Lürick et al.   MOLECULAR BIOLOGY OF THE CELL

GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis

(2016) Laura L. Thomas et al.   JOURNAL OF CELL BIOLOGY

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers

(2016) Megan K. Dennis et al.   JOURNAL OF CELL BIOLOGY

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

Single-filament kinetic studies provide novel insights into regulation of actin-based motility

(2016) Shashank Shekhar et al.   MOLECULAR BIOLOGY OF THE CELL

Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion

(2015) Amy Orr et al.   MOLECULAR BIOLOGY OF THE CELL

FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum

(2015) Ying Li et al.   Scientific Reports

Protein Delivery to Vacuole Requires SAND Protein-Dependent Rab GTPase Conversion for MVB-Vacuole Fusion

(2014) Manoj K. Singh et al.   CURRENT BIOLOGY

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes

(2014) M. Cabrera et al.   JOURNAL OF CELL SCIENCE

Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis

(2014) Y. Cui et al.   PLANT CELL

A distinct tethering step is vital for vacuole membrane fusion

(2014) Michael Zick et al.   eLife

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

(2014) Lars Langemeyer et al.   eLife

RabGEFs are a major determinant for specific Rab membrane targeting

(2013) Julia Blümer et al.   JOURNAL OF CELL BIOLOGY

Rab GTPases and membrane identity: Causal or inconsequential?

(2013) Francis A. Barr   JOURNAL OF CELL BIOLOGY

BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor

(2012) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

Phosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion

(2012) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

(2012) L. K. Oesterlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

(2012) C. Brocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis

(2011) Paola C. Zucchi et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p

(2010) Emi Mizuno-Yamasaki et al.   DEVELOPMENTAL CELL

HOPS Initiates Vacuole Docking by Tethering Membranes before trans-SNARE Complex Assembly

(2010) Christopher M. Hickey et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

Coordination of Rab8 and Rab11 in primary ciliogenesis

(2010) A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA

(2010) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defined Subunit Arrangement and Rab Interactions Are Required for Functionality of the HOPS Tethering Complex

(2010) Clemens W. Ostrowicz et al.   TRAFFIC

Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA

(2009) Hye-Young Suh et al.   EMBO JOURNAL

RabGDI Displacement by DrrA from Legionella Is a Consequence of Its Guanine Nucleotide Exchange Activity

(2009) Stefan Schoebel et al.   MOLECULAR CELL

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components

(2009) C. Stroupe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones

(2008) Joji Mima et al.   EMBO JOURNAL