Mechanisms of nonvesicular lipid transport

Transmembrane phospholipid translocation mediated by Atg9 is involved in autophagosome formation

(2021) Minami Orii et al.   JOURNAL OF CELL BIOLOGY

The endoplasmic reticulum-mitochondria encounter structure: coordinating lipid metabolism across membranes

(2020) Benoît Kornmann   BIOLOGICAL CHEMISTRY

LetB Structure Reveals a Tunnel for Lipid Transport across the Bacterial Envelope

(2020) Georgia L. Isom et al.   CELL

Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

(2020) PeiQi Li et al.   JOURNAL OF CELL BIOLOGY

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

Osh6 requires Ist2 for localization to the ER-PM contacts and efficient phosphatidylserine transport

(2020) Juan Martín D'Ambrosio et al.   JOURNAL OF CELL SCIENCE

ER membranes exhibit phase behavior at sites of organelle contact

(2020) Christopher King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

Phospholipid ebb and flow makes mitochondria go

(2020) Michelle Grace Acoba et al.   JOURNAL OF CELL BIOLOGY

Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

(2020) Carlos M. Guardia et al.   Cell Reports

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins

(2019) Xeni Miliara et al.   Nature Communications

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of unidirectional export of lipopolysaccharide to the cell surface

(2019) Tristan W. Owens et al.   NATURE

Structural basis of lipopolysaccharide extraction by the LptB2FGC complex

(2019) Yanyan Li et al.   NATURE

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking

(2019) Romain Da Costa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis

(2019) Taki Nishimura et al.   MOLECULAR CELL

TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion

(2019) Zhenyuan Tang et al.   Cell Reports

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

(2019) Mikael B.L. Winkler et al.   CELL

Tricalbins Contribute to Cellular Lipid Flux and Form Curved ER-PM Contacts that Are Bridged by Rod-Shaped Structures

(2019) Patrick C. Hoffmann et al.   DEVELOPMENTAL CELL

Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity

(2019) Javier Collado et al.   DEVELOPMENTAL CELL

Integrated regulation of the phosphatidylinositol cycle and phosphoinositide‐driven lipid transport at er‐pm contact sites

(2019) Joshua G. Pemberton et al.   TRAFFIC

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

(2019) Maximilian Schütter et al.   CELL

Exchange of water for sterol underlies sterol egress from a StARkin domain

(2019) George Khelashvili et al.   eLife

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Genetically encoded lipid biosensors

(2018) Rachel C. Wills et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex

(2018) Xiaofeng Qi et al.   SCIENCE

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2)

(2018) Huan Wang et al.   MOLECULAR CELL

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

(2018) Louise H. Wong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Greasing the Wheels of Lipid Biology with Chemical Tools

(2018) Timothy W. Bumpus et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipid exchange at ER-mitochondria contact sites: a puzzle falling into place with quite a few pieces missing

(2018) Carmelina Petrungaro et al.   CURRENT OPINION IN CELL BIOLOGY

Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets

(2017) Norito Tamura et al.   FEBS LETTERS

The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria

(2017) Paola Sperandeo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle

(2017) Aby Grabon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling

(2017) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites

(2017) Arun T. John Peter et al.   JOURNAL OF CELL BIOLOGY

The Vps13p–Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion

(2017) Mithu De et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER

(2017) Muthukumar Kannan et al.   JOURNAL OF LIPID RESEARCH

Speed Limits for Nonvesicular Intracellular Sterol Transport

(2017) Jeremy S. Dittman et al.   TRENDS IN BIOCHEMICAL SCIENCES

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Structure of human Niemann–Pick C1 protein

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

(2016) Antonella Chiapparino et al.   PROGRESS IN LIPID RESEARCH

TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy inDictyosteliumand human HeLa cells

(2015) Sandra Muñoz-Braceras et al.   Autophagy

APP controls the formation of PI(3,5)P2 vesicles through its binding of the PIKfyve complex

(2015) Heather Currinn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Arabidopsis TRIGALACTOSYLDIACYLGLYCEROL5 Interacts with TGD1, TGD2, and TGD4 to Facilitate Lipid Transfer from the Endoplasmic Reticulum to Plastids

(2015) Jilian Fan et al.   PLANT CELL

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes

(2015) Joachim Moser von Filseck et al.   Nature Communications

Molecular probes to visualize the location, organization and dynamics of lipids

(2014) M. Maekawa et al.   JOURNAL OF CELL SCIENCE

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae

(2013) K. Suzuki et al.   JOURNAL OF CELL SCIENCE

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

TGD1, -2, and -3 Proteins Involved in Lipid Trafficking Form ATP-binding Cassette (ABC) Transporter with Multiple Substrate-binding Proteins

(2012) Rebecca L. Roston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae

(2012) C. Voss et al.   JOURNAL OF CELL SCIENCE

VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae

(2012) Jae-Sook Park et al.   JOURNAL OF CELL SCIENCE

Effect of tension and curvature on the chemical potential of lipids in lipid aggregates

(2012) Andrea Grafmüller et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

TGD4 involved in endoplasmic reticulum-to-chloroplast lipid trafficking is a phosphatidic acid binding protein

(2012) Zhen Wang et al.   PLANT JOURNAL

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

STARD4 abundance regulates sterol transport and sensing

(2011) Bruno Mesmin et al.   MOLECULAR BIOLOGY OF THE CELL

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Binding and release of cholesterol in the Osh4 protein of yeast

(2008) Rishi P. Singh et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS