SKIP ‐ HOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport

USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7

(2019) Aysegul Sapmaz et al.   Nature Communications

Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex

(2018) Matthew N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy

(2018) Job Fermie et al.   TRAFFIC

A guanine nucleotide exchange factor (GEF) limits Rab GTPase–driven membrane fusion

(2017) Lars Langemeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability

(2017) Jing Pu et al.   JOURNAL OF CELL BIOLOGY

The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes

(2017) Rituraj Marwaha et al.   JOURNAL OF CELL BIOLOGY

Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos

(2017) Miho Oka et al.   JOURNAL OF CELL SCIENCE

The EGFR odyssey – from activation to destruction in space and time

(2017) Jeroen Bakker et al.   JOURNAL OF CELL SCIENCE

Automated tilt series alignment and tomographic reconstruction in IMOD

(2017) David N. Mastronarde et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function

(2017) Jacques Neefjes et al.   TRENDS IN CELL BIOLOGY

Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy

(2016) Daphne M. van Elsland et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphoinositides in Control of Membrane Dynamics

(2016) Kay O. Schink et al.   Annual Review of Cell and Developmental Biology

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Lysosomal signaling in control of degradation pathways

(2016) Lukas A Huber et al.   CURRENT OPINION IN CELL BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus

(2016) Nadia Jaber et al.   JOURNAL OF CELL SCIENCE

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

IVA cloning: A single-tube universal cloning system exploiting bacterial In Vivo Assembly

(2016) Javier García-Nafría et al.   Scientific Reports

PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection

(2015) David G. McEwan et al.   Cell Host & Microbe

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

(2015) Rik van der Kant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

(2015) D. Khatter et al.   JOURNAL OF CELL SCIENCE

Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole

(2015) Meenakshi Rana et al.   MOLECULAR BIOLOGY OF THE CELL

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of the cytoskeleton and molecular motors in endosomal dynamics

(2014) Elizabeth Granger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

The role of membrane-trafficking small GTPases in the regulation of autophagy

(2013) C. F. Bento et al.   JOURNAL OF CELL SCIENCE

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

(2012) Kenta Onoue et al.   JOURNAL OF CELL SCIENCE

Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan

(2012) Sara Sigismund et al.   PHYSIOLOGICAL REVIEWS

Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages

(2012) Amra Mrakovic et al.   TRAFFIC

TBC proteins: GAPs for mammalian small GTPase Rab?

(2011) Mitsunori Fukuda   BIOSCIENCE REPORTS

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

(2011) Salil Garg et al.   IMMUNITY

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases

(2011) Mark P.A. Luna-Vargas et al.   JOURNAL OF STRUCTURAL BIOLOGY

A new approach to improve the quality of ultrathin cryo-sections; its use for immunogold EM and correlative electron cryo-tomography

(2011) Erik Bos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence

(2010) Eigen R. Peralta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular bodies: co-ordinated progression to maturity

(2008) Philip G Woodman et al.   CURRENT OPINION IN CELL BIOLOGY

E2F in vivo binding specificity: Comparison of consensus versus nonconsensus binding sites

(2008) A. Rabinovich et al.   GENOME RESEARCH

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE