Multiple Roles of the Small GTPase Rab7

Autophagic lysosomal reformation depends on mTOR reactivation in H2O2-induced autophagy

(2016) Jiqian Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

(2016) Swapnil Rohidas Shinde et al.   Nature Communications

Role of Intermediate Filaments in Vesicular Traffic

(2016) Azzurra Margiotta et al.   Cells

Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria

(2015) Fumika Koyano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex

(2015) Jeffrey P Bombardier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles

(2015) Nicolas Jaé et al.   FEBS LETTERS

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

The HabcDomain of the SNARE Vam3 Interacts with the HOPS Tethering Complex to Facilitate Vacuole Fusion

(2015) Anna Lürick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity

(2015) Rik van der Kant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mon1–Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells

(2015) Sayaka Yasuda et al.   JOURNAL OF CELL SCIENCE

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

(2015) D. Khatter et al.   JOURNAL OF CELL SCIENCE

HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation

(2015) J. Inoue et al.   JOURNAL OF CELL SCIENCE

Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line

(2015) Anna Mascia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PTEN Functions by Recruitment to Cytoplasmic Vesicles

(2015) Adam Naguib et al.   MOLECULAR CELL

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

(2015) Lena Wartosch et al.   TRAFFIC

Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages

(2015) Pallavi Chandra et al.   Scientific Reports

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

RAB7 Controls Melanoma Progression by Exploiting a Lineage-Specific Wiring of the Endolysosomal Pathway

(2014) Direna Alonso-Curbelo et al.   CANCER CELL

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

(2014) Konstantinos Palikaras et al.   EXPERIMENTAL GERONTOLOGY

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

(2014) Agne Kazlauskaite et al.   FEBS Journal

Structural Identification of the Vps18 β-Propeller Reveals a Critical Role in the HOPS Complex Stability and Function

(2014) Heide Behrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit

(2014) M. De Luca et al.   JOURNAL OF CELL SCIENCE

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles

(2014) H. Arlt et al.   JOURNAL OF CELL SCIENCE

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes

(2014) M. Cabrera et al.   JOURNAL OF CELL SCIENCE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities

(2014) Che-Hong Chen et al.   PHYSIOLOGICAL REVIEWS

Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression

(2014) Joshua J. Steffan et al.   PLoS One

Overexpression of a Vesicle Trafficking Gene, OsRab7, Enhances Salt Tolerance in Rice

(2014) Xiaojue Peng et al.   TheScientificWorldJOURNAL

Molecular Insights into Rab7-Mediated Endosomal Recruitment of Core Retromer: Deciphering the Role of Vps26 and Vps35

(2014) Amulya Priya et al.   TRAFFIC

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking

(2014) Xiaosi Lin et al.   Scientific Reports

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

(2014) Koji Yamano et al.   eLife

Vimentin phosphorylation and assembly are regulated by the small GTPase Rab7a

(2013) Laura Cogli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

(2013) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Rab7 Is Functionally Required for Selective Cargo Sorting at the Early Endosome

(2013) Emmanuelle Girard et al.   TRAFFIC

Charcot–Marie–Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin

(2012) Laura Cogli et al.   ACTA NEUROPATHOLOGICA

GTPase Networks in Membrane Traffic

(2012) Emi Mizuno-Yamasaki et al.   Annual Review of Biochemistry

Functional analysis of the protein phosphatase activity of PTEN

(2012) Xiaoqun Catherine Zhang et al.   BIOCHEMICAL JOURNAL

Molecular basis of Charcot–Marie–Tooth type 2B disease

(2012) Cecilia Bucci et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Rab7 Silencing Prevents  -Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy

(2012) S. A. Mousa et al.   DIABETES

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes

(2012) Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation

(2012) Ting-Ting Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Erratum: Illuminating the functional and structural repertoire of human TBC/RABGAPs

(2012) Marieke A. M. Frasa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

(2012) C. Brocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charcot–Marie–Tooth disease and intracellular traffic

(2012) Cecilia Bucci et al.   PROGRESS IN NEUROBIOLOGY

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

(2012) P. Tibarewal et al.   Science Signaling

Dynamics of Rab7b-Dependent Transport of Sorting Receptors

(2012) Cinzia Progida et al.   TRAFFIC

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Neuronal Autophagy: A Housekeeper or a Fighter in Neuronal Cell Survival?

(2012) Jin-A Lee   Experimental Neurobiology

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Mitochondria Autophagy in Yeast

(2011) Tomotake Kanki et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

TBC proteins: GAPs for mammalian small GTPase Rab?

(2011) Mitsunori Fukuda   BIOSCIENCE REPORTS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities

(2011) JO Agola et al.   CLINICAL GENETICS

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis

(2011) William H. Hoffman et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Phosphorylation of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and Its Vesicle-associated Membrane Protein 7 (VAMP7)-dependent Trafficking Facilitate Cell Invasion and Migration

(2011) Karla C. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal

(2011) Tuanlao Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction

(2011) Sho W. Suzuki et al.   PLoS One

Fission of Tubular Endosomes Triggers Endosomal Acidification and Movement

(2011) Kumi Mesaki et al.   PLoS One

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

CMT2B-associated Rab7 mutants inhibit neurite outgrowth

(2010) Laura Cogli et al.   ACTA NEUROPATHOLOGICA

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Endosome–lysosome fusion: Figure 1

(2010) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial aldehyde dehydrogenase and cardiac diseases

(2010) Che-Hong Chen et al.   CARDIOVASCULAR RESEARCH

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Rab7: Role of its protein interaction cascades in endo-lysosomal traffic

(2010) Tuanlao Wang et al.   CELLULAR SIGNALLING

Perturbation of Cullin Deneddylation via Conditional Csn8 Ablation Impairs the Ubiquitin–Proteasome System and Causes Cardiomyocyte Necrosis and Dilated Cardiomyopathy in Mice

(2010) Huabo Su et al.   CIRCULATION RESEARCH

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers

(2010) J. J. Steffan et al.   JOURNAL OF CELL SCIENCE

Rab7b controls trafficking from endosomes to the TGN

(2010) C. Progida et al.   JOURNAL OF CELL SCIENCE

The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome

(2010) Henning J. kleine Balderhaar et al.   JOURNAL OF CELL SCIENCE

The mood stabilizer valproic acid improves defective neurite formation caused by charcot-marie-tooth disease-associated mutant Rab7 through the JNK signaling pathway

(2010) Junji Yamauchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes

(2010) Nobumichi Furuta et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking

(2010) Takeshi Kawauchi et al.   NEURON

Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro

(2010) Meagan Barclay et al.   NEUROSCIENCE LETTERS

IGF-I stimulates Rab7-RILP interaction during neuronal autophagy

(2010) Mona Bains et al.   NEUROSCIENCE LETTERS

Rab GTPases implicated in inherited and acquired disorders

(2010) Shreya Mitra et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Rab7 and the CMT2B disease

(2009) Laura Cogli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Intermediate vimentin filaments and their role in intracellular organelle distribution

(2009) A. A. Minin et al.   BIOCHEMISTRY-MOSCOW

Vps-C complexes: gatekeepers of endolysosomal traffic

(2009) Daniel P Nickerson et al.   CURRENT OPINION IN CELL BIOLOGY

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

(2009) Brett A. McCray et al.   HUMAN MOLECULAR GENETICS

Insulin-like Growth Factor-I Prevents the Accumulation of Autophagic Vesicles and Cell Death in Purkinje Neurons by Increasing the Rate of Autophagosome-to-lysosome Fusion and Degradation

(2009) Mona Bains et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic properties of intermediate filaments during organelle transport

(2009) L. Chang et al.   JOURNAL OF CELL SCIENCE

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Introducing intermediate filaments: from discovery to disease

(2009) John E. Eriksson et al.   JOURNAL OF CLINICAL INVESTIGATION

Intermediate filaments: primary determinants of cell architecture and plasticity

(2009) Harald Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Rab7 Activation by Growth Factor Withdrawal Contributes to the Induction of Apoptosis

(2009) Kimberly Romero Rosales et al.   MOLECULAR BIOLOGY OF THE CELL

A Genomic Screen for Yeast Mutants Defective in Selective Mitochondria Autophagy

(2009) Tomotake Kanki et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes

(2009) V. Soppina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thiazolidinediones Induce Rab7-RILP-MAPK-Dependent Juxtanuclear Lysosome Aggregation and Reduce Tumor Cell Invasion

(2009) Joshua J. Steffan et al.   TRAFFIC

Characterization of the Rab7K157N mutant protein associated with Charcot–Marie-Tooth type 2B

(2008) Azzurra De Luca et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Long QT Syndrome–Associated Mutations in KCNQ1 and KCNE1 Subunits Disrupt Normal Endosomal Recycling of I Ks Channels

(2008) Guiscard Seebohm et al.   CIRCULATION RESEARCH

Intermediate filaments: versatile building blocks of cell structure

(2008) Robert D Goldman et al.   CURRENT OPINION IN CELL BIOLOGY

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease

(2008) M. R. Spinosa et al.   JOURNAL OF NEUROSCIENCE

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Neuronal intermediate filament expression in rat dorsal root ganglia sensory neurons: An in vivo and in vitro study

(2008) M. Fornaro et al.   NEUROSCIENCE

Ndel1 Promotes Axon Regeneration via Intermediate Filaments

(2008) Cory Toth et al.   PLoS One

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES