Rab2 promotes autophagic and endocytic lysosomal degradation

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy

(2017) Naonobu Fujita et al.   eLife

RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs

(2016) Hiroaki Kajiho et al.   EMBO REPORTS

Improved reconstitution of yeast vacuole fusion with physiological SNARE concentrations reveals an asymmetric Rab(GTP) requirement

(2016) Michael Zick et al.   MOLECULAR BIOLOGY OF THE CELL

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes

(2016) Zheng Wang et al.   MOLECULAR CELL

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

MiniCORVET is a Vps8-containing early endosomal tether in Drosophila

(2016) Péter Lőrincz et al.   eLife

An antibody toolkit for the study of membrane traffic inDrosophila melanogaster

(2016) Falko Riedel et al.   Biology Open

The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

(2015) D. Khatter et al.   JOURNAL OF CELL SCIENCE

Cellular functions of Rab GTPases at a glance

(2015) Y. Zhen et al.   JOURNAL OF CELL SCIENCE

How and why to study autophagy in Drosophila: It’s more than just a garbage chute

(2015) Péter Nagy et al.   METHODS

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila

(2015) Tamás Maruzs et al.   TRAFFIC

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Toward a Comprehensive Map of the Effectors of Rab GTPases

(2014) Alison K. Gillingham et al.   DEVELOPMENTAL CELL

Assays to monitor autophagy in Drosophila

(2014) Caroline Mauvezin et al.   METHODS

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

(2014) Szabolcs Takáts et al.   MOLECULAR BIOLOGY OF THE CELL

Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity duringDrosophilaWing Development

(2014) Péter Lőrincz et al.   Biomed Research International

Tethering complexes in the endocytic pathway: CORVET and HOPS

(2013) Jachen A. Solinger et al.   FEBS Journal

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module

(2013) Gábor Glatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

(2013) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function

(2013) Smita Cherry et al.   eLife

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

(2012) Karolina Pircs et al.   PLoS One

The HOPS Proteins hVps41 and hVps39 Are Required for Homotypic and Heterotypic Late Endosome Fusion

(2012) Maaike S. Pols et al.   TRAFFIC

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation

(2010) P. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAB2A: A Major Subacrosomal Protein of Bovine Spermatozoa Implicated in Acrosomal Biogenesis1

(2008) Jeremi R. Mountjoy et al.   BIOLOGY OF REPRODUCTION

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE