Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification

Hemadsorption

(2021) Salvatore Lucio Cutuli et al.   Current Opinion in Anesthesiology

Toll-Like Receptors in Acute Kidney Injury

(2021) Cristina Vázquez-Carballo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock

(2021) Hisataka Shoji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Thrombomodulin in Reducing Lethality and Suppressing Neutrophil Extracellular Trap Formation in the Lungs and Liver in a Lipopolysaccharide-Induced Murine Septic Shock Model

(2021) Yu Kato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies

(2021) Ramy S. Gabarin et al.   Journal of Innate Immunity

Reconsidering adsorption in hemodialysis: is it just an epiphenomenon? A narrative review

(2021) Nans Florens et al.   JOURNAL OF NEPHROLOGY

Comparison of myoglobin clearance in three types of blood purification modalities

(2021) Shinya Suzuki et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Association of plasma level of high-mobility group box-1 with necroptosis and sepsis outcomes

(2021) Hongseok Yoo et al.   Scientific Reports

Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis

(2021) Zhaoyuan Chen et al.   Frontiers in Cellular and Infection Microbiology

Targeting Neutrophils in Sepsis: From Mechanism to Translation

(2021) Xiaofei Shen et al.   Frontiers in Pharmacology

Dysregulated Immunity and Immunotherapy after Sepsis

(2021) Dijoia B. Darden et al.   Journal of Clinical Medicine

Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury

(2021) Chao Deng et al.   ACTA PHARMACOLOGICA SINICA

New insights into lipopolysaccharide inactivation mechanisms in sepsis

(2021) Eréndira Guadalupe Pérez-Hernández et al.   BIOMEDICINE & PHARMACOTHERAPY

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

(2021) Rajendra Karki et al.   TRENDS IN IMMUNOLOGY

Can the cytokine adsorber CytoSorb® help to mitigate cytokine storm and reduce mortality in critically ill patients? A propensity score matching analysis

(2021) Christina Scharf et al.   Annals of Intensive Care

GLYCOCALYX IN ENDOTOXEMIA AND SEPSIS

(2020) Michael S. Goligorsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial Responses in Sepsis

(2020) Jérémie Joffre et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

In vitro Evaluation of Linezolid and Doripenem Clearance with Different Hemofilters

(2020) Toshihisa Hiraiwa et al.   BLOOD PURIFICATION

Recent Advances in Lipopolysaccharide Recognition Systems

(2020) Lalita Mazgaeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

Immunotherapy in sepsis - brake or accelerate?

(2020) Folkert Steinhagen et al.   PHARMACOLOGY & THERAPEUTICS

The effects of sepsis on endothelium and clinical implications

(2020) Elena V Dolmatova et al.   CARDIOVASCULAR RESEARCH

TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

(2020) Yao Wang et al.   CELL PROLIFERATION

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

(2020) Jean‐Marc Cavaillon et al.   EMBO Molecular Medicine

Involvement of ionic interactions in cytokine adsorption of polyethyleneimine-coated polyacrylonitrile and polymethyl methacrylate membranes in vitro

(2020) Kazuhiro Moriyama et al.   JOURNAL OF ARTIFICIAL ORGANS

Adsorption kinetics of high mobility group box 1 protein in a polyacrylonitrile hemofiltration membrane

(2020) Tomoyuki Nakamura et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways

(2020) Alla Zamyatina et al.   Frontiers in Immunology

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Hemoadsorption therapy in the critically ill: solid base but clinical haze

(2019) Patrick M. Honoré et al.   Annals of Intensive Care

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes

(2019) Bozhi Ye et al.   Drug Design Development and Therapy

Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

(2019) Anja Pfalzgraff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Histidine‐rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF‐κB and MAPK signal pathway

(2019) Shangze Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis

(2019) Congqing Wu et al.   IMMUNITY

The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

(2019) Naijun Miao et al.   KIDNEY INTERNATIONAL

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Cytokine removal in human septic shock: Where are we and where are we going?

(2019) Patrick M. Honore et al.   Annals of Intensive Care

Blood Purification and Mortality in Sepsis and Septic Shock

(2019) Alessandro Putzu et al.   ANESTHESIOLOGY

High Mobility Group Box-1 (HMGB1): A potential target in therapeutics

(2019) Eyaldeva C. Vijayakumar et al.   CURRENT DRUG TARGETS

Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

(2019) Sadudee Peerapornratana et al.   KIDNEY INTERNATIONAL

Sepsis: Inflammation Is a Necessary Evil

(2019) Christina Nedeva et al.   Frontiers in Cell and Developmental Biology

Blood Purification Techniques for Sepsis and Septic AKI

(2019) Thibaut Girardot et al.   SEMINARS IN NEPHROLOGY

The Pathogenesis of Sepsis and Potential Therapeutic Targets

(2019) Min Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Caspase-11 signaling enhances graft-versus-host disease

(2019) Yanyan Lu et al.   Nature Communications

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure

(2019) Xinyu Yang et al.   IMMUNITY

In Vitro Study of Endotoxin Adsorption by a Polymyxin B-Immobilized Fiber Column

(2018) Chizuru Yamashita et al.   BLOOD PURIFICATION

Neutrophils as effectors of vascular inflammation

(2018) Diego Gómez-Moreno et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

Paradigms of acute kidney injury in the intensive care setting

(2018) John A. Kellum et al.   Nature Reviews Nephrology

Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads

(2018) Maryann C. Gruda et al.   PLoS One

Neutrophil Activation During Septic Shock

(2018) Laure Stiel et al.   SHOCK

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

(2018) Anthony Bonavia et al.   BLOOD PURIFICATION

A Double-Blind Randomized Controlled Trial of High Cutoff Versus Standard Hemofiltration in Critically Ill Patients With Acute Kidney Injury

(2018) Rafidah Atan et al.   CRITICAL CARE MEDICINE

Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis

(2018) Toshiaki Iba et al.   THROMBOSIS RESEARCH

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation

(2018) Eui Ho Kim et al.   CELL DEATH AND DIFFERENTIATION

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level

(2018) R. Phillip Dellinger et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Derangement of the endothelial glycocalyx in sepsis

(2018) Toshiaki Iba et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical study of blood purification therapy in critical care in Japan: results from the survey research of the Japan Society for Blood Purification in Critical Care in 2013

(2017) Toshiaki Arimura et al.   JOURNAL OF ARTIFICIAL ORGANS

Neutrophil dysregulation during sepsis: an overview and update

(2017) Xiao-Fei Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis

(2017) T. Iba et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal replacement therapy intensity for acute kidney injury and recovery to dialysis independence: a systematic review and individual patient data meta-analysis

(2017) Ying Wang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: A randomized controlled trial

(2017) Dirk Schädler et al.   PLoS One

Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling

(2016) Franziska Kopp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Innate cell communication kick-starts pathogen-specific immunity

(2016) Amariliz Rivera et al.   NATURE IMMUNOLOGY

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Immune Cell Phenotype and Function in Sepsis

(2016) Thomas Rimmelé et al.   SHOCK

Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious

(2016) Fabiane Sônego et al.   Frontiers in Immunology

Caspase-11: arming the guards against bacterial infection

(2015) Irma Stowe et al.   IMMUNOLOGICAL REVIEWS

Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial

(2015) Didier M. Payen et al.   INTENSIVE CARE MEDICINE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Novel Blood Purification System for Regulating Excessive Immune Reactions in Severe Sepsis and Septic Shock: An Ex Vivo Pilot Study

(2015) Yoshitaka Hara et al.   THERAPEUTIC APHERESIS AND DIALYSIS

In Vitro Evaluation of High Mobility Group Box 1 Protein Removal with Various Membranes for Continuous Hemofiltration

(2015) Miho Yumoto et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Continuous Hemodiafiltration with a Cytokine-Adsorbing Hemofilter in Patients with Septic Shock: A Preliminary Report

(2014) Hidetoshi Shiga et al.   BLOOD PURIFICATION

The systemic immune response to trauma: an overview of pathophysiology and treatment

(2014) Janet M Lord et al.   LANCET

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Newly Designed CRRT Membranes for Sepsis and SIRS—A Pragmatic Approach for Bedside Intensivists Summarizing the More Recent Advances

(2013) Patrick M. Honore et al.   ASAIO JOURNAL

High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial

(2013) Olivier Joannes-Boyau et al.   INTENSIVE CARE MEDICINE

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis study failure highlights need for trial design rethink

(2013) Man Tsuey Tse   NATURE REVIEWS DRUG DISCOVERY

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Continuous Hemodiafiltration with a Cytokine-Adsorbing Hemofilter for Sepsis

(2012) Hiroyuki Hirasawa et al.   BLOOD PURIFICATION

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

HMGB1 Increases Permeability of the Endothelial Cell Monolayer via RAGE and Src Family Tyrosine Kinase Pathways

(2011) Wenchang Huang et al.   INFLAMMATION

Interleukin-6 in Sepsis and Capillary Leakage Syndrome

(2011) Alexander Krüttgen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cellulose Acetate Beads Activate the Complement System but Inactivate the Anaphylatoxins Generated

(2010) Yuji Takeda et al.   ARTIFICIAL ORGANS

The mode of actions of the Adacolumn therapeutic leucocytapheresis in patients with inflammatory bowel disease: a concise review

(2010) H. Hanai et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sepsis and Endothelial Permeability

(2010) Warren L. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock

(2009) Dinna N. Cruz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Are the synergistic effects of high-volume haemofiltration and enhanced adsorption the missing key in sepsis modulation?

(2008) O. Joannes-Boyau et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

THE ROLE OF NEUTROPHILS IN SEVERE SEPSIS

(2008) José C. Alves-Filho et al.   SHOCK