Caspase-11 signaling enhances graft-versus-host disease

LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation

(2018) José Carlos Santos et al.   EMBO JOURNAL

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease

(2017) Jérôme Legoff et al.   NATURE MEDICINE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

(2016) Yusuke Shono et al.   Science Translational Medicine

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

(2014) D Demon et al.   Mucosal Immunology

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage

(2014) Lukas Schwab et al.   NATURE MEDICINE

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

(2011) Motoko Koyama et al.   NATURE MEDICINE

The Protective Role of Host Toll-Like Receptor-4 in Acute Graft-Versus-Host Disease

(2010) Takehito Imado et al.   TRANSPLANTATION

Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors

(2009) O. Penack et al.   BLOOD