Mechanisms and treatment of organ failure in sepsis

Intraabdominal Hypertension, Abdominal Compartment Syndrome, and the Open Abdomen

(2018) William Kirke Rogers et al.   CHEST

Novel Interventions

(2018) Jean-Louis Vincent et al.   CRITICAL CARE CLINICS

Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine

(2018) Can Ince et al.   INTENSIVE CARE MEDICINE

Renal perfusion in sepsis: from macro- to microcirculation

(2017) Emiel Hendrik Post et al.   KIDNEY INTERNATIONAL

Salmonella- induced inflammasome activation in humans

(2017) Damien Bierschenk et al.   MOLECULAR IMMUNOLOGY

Metabolic reprogramming and tolerance during sepsis-induced AKI

(2017) Hernando Gómez et al.   Nature Reviews Nephrology

Angiotensin II for the Treatment of Vasodilatory Shock

(2017) Ashish Khanna et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis

(2017) Alexandre Kanashiro et al.   PHARMACOLOGICAL RESEARCH

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial

(2017) Geoff Bellingan et al.   Trials

Influence of Microbes on Neutrophil Life and Death

(2017) Scott D. Kobayashi et al.   Frontiers in Cellular and Infection Microbiology

The Role of Autophagy in Critical Illness-induced Liver Damage

(2017) Steven E. Thiessen et al.   Scientific Reports

Positive fluid balance as a major predictor of clinical outcome of patients with sepsis/septic shock after ICU discharge

(2016) Evgeni Brotfain et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Lung–Kidney Cross-Talk in the Critically Ill Patient

(2016) Faeq Husain-Syed et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apoptosis-induced lymphopenia in sepsis and other severe injuries

(2016) Thibaut Girardot et al.   APOPTOSIS

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

Ubiquitin signaling in immune responses

(2016) Hongbo Hu et al.   CELL RESEARCH

The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness

(2016) Nathan J. Klingensmith et al.   CRITICAL CARE CLINICS

Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

(2016)   INTENSIVE CARE MEDICINE

Vagal Modulation of the Inflammatory Response in Sepsis

(2016) Da-Wei Wang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis

(2016) Lonneke A. van Vught et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

(2016) Matthew J. Delano et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnostic Utility of Different Blood Components in Gene Expression Analysis of Sepsis

(2016) David M. Maslove et al.   SHOCK

Danger in the Intensive Care Unit

(2016) Kim Timmermans et al.   SHOCK

Immune Cell Phenotype and Function in Sepsis

(2016) Thomas Rimmelé et al.   SHOCK

Mitochondrial Function in Sepsis

(2016) Nishkantha Arulkumaran et al.   SHOCK

The microbiome and critical illness

(2016) Robert P Dickson   Lancet Respiratory Medicine

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

(2015) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The coagulopathy of acute sepsis

(2015) Jeff Simmons et al.   Current Opinion in Anesthesiology

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Mcl-1 is vital for neutrophil survival

(2015) Mark P. Murphy et al.   IMMUNOLOGIC RESEARCH

Bacterial recognition pathways that lead to inflammasome activation

(2015) Kelly M. Storek et al.   IMMUNOLOGICAL REVIEWS

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI

(2015) Ana Carolina P. Souza et al.   KIDNEY INTERNATIONAL

Catecholamine Use is Associated With Enterocyte Damage in Critically Ill Patients

(2015) Gaël Piton et al.   SHOCK

Prevention and treatment of sepsis-induced acute kidney injury: an update

(2015) Patrick M. Honore et al.   Annals of Intensive Care

The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients

(2014) Maya Hites et al.   ADVANCED DRUG DELIVERY REVIEWS

MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury

(2014) Praveen Mannam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Small Acute Increases in Serum Creatinine Are Associated with Decreased Long-Term Survival in the Critically Ill

(2014) Adam Linder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of ghrelin on sepsis-induced acute kidney injury: one step forward

(2014) Akef Khowailed et al.   Clinical and Experimental Nephrology

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Myocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment

(2014) Elio Antonucci et al.   JOURNAL OF CRITICAL CARE

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Revisiting caspases in sepsis

(2014) M Aziz et al.   Cell Death & Disease

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change?

(2013) Jenneke Leentjens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Enterocyte Damage in Critically Ill Patients Is Associated With Shock Condition and 28-Day Mortality*

(2013) Gaël Piton et al.   CRITICAL CARE MEDICINE

Microcirculatory Alterations in Patients With Severe Sepsis

(2013) Daniel De Backer et al.   CRITICAL CARE MEDICINE

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fluid management for the prevention and attenuation of acute kidney injury

(2013) John R. Prowle et al.   Nature Reviews Nephrology

Circulatory Shock

(2013) Jean-Louis Vincent et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

(2013) Vincent C. Tam   SEMINARS IN IMMUNOLOGY

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Redefining the gut as the motor of critical illness

(2013) Rohit Mittal et al.   TRENDS IN MOLECULAR MEDICINE

The role of mitochondrial dysfunction in sepsis-induced multi-organ failure

(2013) Mervyn Singer   Virulence

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

(2013) Daniel De Backer et al.   Virulence

Fluid Management and Use of Diuretics in Acute Kidney Injury

(2012) Annie-Claire Nadeau-Fredette et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

The Adult Respiratory Distress Syndrome Cognitive Outcomes Study

(2012) Mark E. Mikkelsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness*

(2012) Jan Gunst et al.   CRITICAL CARE MEDICINE

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Notice

(2012)   Kidney International Supplements

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis

(2011) Sarah L. Tressel et al.   EMBO Molecular Medicine

Microdialysis-assessed interstitium alterations during sepsis: relationship to stage, infection, and pathogen

(2011) Petros Kopterides et al.   INTENSIVE CARE MEDICINE

Acute intestinal failure in critically ill patients: is plasma citrulline the right marker?

(2011) Gaël Piton et al.   INTENSIVE CARE MEDICINE

Drug dosing consideration in patients with acute and chronic kidney disease—a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)

(2011) Gary R. Matzke et al.   KIDNEY INTERNATIONAL

Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis

(2010) Jane E. Carré et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute respiratory distress syndrome, mechanical ventilation, and right ventricular function

(2010) Koceila Bouferrache et al.   Current Opinion in Critical Care

Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside

(2010) B. Levy et al.   INTENSIVE CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy

(2010) Sang Won Park et al.   LABORATORY INVESTIGATION

Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection

(2009) Fabiano Pinheiro da Silva et al.   APOPTOSIS

Soluble Thrombomodulin Protects Ischemic Kidneys

(2009) A. A. Sharfuddin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain

(2008) M. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy

(2008) Christina L. Klein et al.   KIDNEY INTERNATIONAL

THE PROTECTIVE EFFECT OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY AGAINST SEPTIC SHOCK IN RATS

(2008) Xue-Min Song et al.   SHOCK