Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis

Heme as a Target for Therapeutic Interventions

(2017) Stephan Immenschuh et al.   Frontiers in Pharmacology

DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC

(2016) Patricia C. Liaw et al.   BLOOD REVIEWS

Early Detection of Disseminated Intravascular Coagulation During Septic Shock

(2016) Xavier Delabranche et al.   CRITICAL CARE MEDICINE

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

Phosphatidylserine externalization and procoagulant activation of erythrocytes induced byPseudomonas aeruginosavirulence factor pyocyanin

(2016) Syed M. Qadri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials

(2016) Y. Umemura et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3In Vitro

(2016) Toshiaki Iba et al.   MICROCIRCULATION

Antithrombin: anti-inflammatory properties and clinical applications

(2016) Roman M. Sniecinski et al.   THROMBOSIS AND HAEMOSTASIS

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

(2016) Susanne Pfeiler et al.   HAEMATOLOGICA

von Willebrand factor propeptide: biology and clinical utility

(2015) S. L. Haberichter   BLOOD

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Present and future of anticoagulant therapy using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation: a perspective from Japan

(2015) Toshiaki Iba et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis

(2015) K. Yamakawa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI

(2015) Ana Carolina P. Souza et al.   KIDNEY INTERNATIONAL

The role of platelets in the recruitment of leukocytes during vascular disease

(2015) G. Ed Rainger et al.   PLATELETS

Coagulation in Patients with Severe Sepsis

(2015) Tom Poll et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

ADAMTS-13 in Critically Ill Patients With Septic Syndromes and Noninfectious Systemic Inflammatory Response Syndrome

(2015) Jesús Aibar et al.   SHOCK

The role of platelets in inflammation

(2015) Robert Storey et al.   THROMBOSIS AND HAEMOSTASIS

Triggers, Inhibitors, Mechanisms, and Significance of Eryptosis: The Suicidal Erythrocyte Death

(2015) Elisabeth Lang et al.   Biomed Research International

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

An Increase in Mean Platelet Volume from Baseline Is Associated with Mortality in Patients with Severe Sepsis or Septic Shock

(2015) Chan Ho Kim et al.   PLoS One

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Erythrocyte and Leukocyte: Two Partners in Bacteria Killing

(2014) Hayk A. Minasyan   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytosis of Staphylococcus aureus by Human Neutrophils Prevents Macrophage Efferocytosis and Induces Programmed Necrosis

(2014) M. C. Greenlee-Wacker et al.   JOURNAL OF IMMUNOLOGY

Beta (β)-antithrombin activity in children and adults: implications for heparin therapy in infants and children

(2014) V. Karlaftis et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiology of severe sepsis in Japanese intensive care units: A prospective multicenter study

(2013) Hiroshi Ogura et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the red cell membrane in thrombin generation

(2013) Matthew F. Whelihan et al.   THROMBOSIS RESEARCH

Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

(2012) Maurits L. van Montfoort et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Role of microparticles in sepsis

(2012) V.L. Reid et al.   BRITISH JOURNAL OF ANAESTHESIA

Leukocyte-Derived Microparticles in Vascular Homeostasis

(2012) Anne Angelillo-Scherrer   CIRCULATION RESEARCH

Damage- and Pathogen-Associated Molecular Patterns and Alarmins: Keys to Sepsis?

(2012) S. Denk et al.   EUROPEAN SURGICAL RESEARCH

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging role of neutrophils in thrombosis—the journey of TF through NETs

(2012) Konstantinos Kambas et al.   Frontiers in Immunology

Beyond Thrombosis

(2011) Jason N. Katz et al.   CHEST

Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)

(2011) Rithwik Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation-Associated Autophagy-Related Programmed Necrotic Death of Human Neutrophils Characterized by Organelle Fusion Events

(2011) C. C. Mihalache et al.   JOURNAL OF IMMUNOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potential

(2010) B. F. Becker et al.   CARDIOVASCULAR RESEARCH

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Platelets and innate immunity

(2009) John W. Semple et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats*

(2009) Satar Mortaza et al.   CRITICAL CARE MEDICINE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells

(2008) A. Shibamiya et al.   BLOOD

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE

Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor

(2008) C. L. Bockmeyer et al.   HAEMATOLOGICA