Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen–host interactions

(2020) Julia Sanchez‐Garrido et al.   CELLULAR MICROBIOLOGY

LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

(2020) Wenbo Li et al.   Frontiers in Immunology

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

(2020) Michal P. Wandel et al.   NATURE IMMUNOLOGY

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction

(2019) Jinsu An et al.   Scientific Reports

Intracellular Lipopolysaccharide Sensing as a Potential Therapeutic Target for Sepsis

(2019) Anja Pfalzgraff et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Detecting lipopolysaccharide in the cytosol of mammalian cells: Lessons from MD-2/TLR4

(2019) Jason H. Barker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PmrC (EptA) and CptA Negatively Affect Outer Membrane Vesicle Production in Citrobacter rodentium

(2019) Anshul Sinha et al.   JOURNAL OF BACTERIOLOGY

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

(2019) Yunhao Tan et al.   CELL

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity

(2019) Chunfu Yang et al.   mBio

TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model

(2019) Huaping Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A DedA Family Membrane Protein Is Required for Burkholderia thailandensis Colistin Resistance

(2019) Pradip R. Panta et al.   Frontiers in Microbiology

LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation

(2018) José Carlos Santos et al.   EMBO JOURNAL

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity

(2018) José Carlos Santos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis

(2018) Yu-Lei Gao et al.   MEDIATORS OF INFLAMMATION

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics

(2018) Florian Adanitsch et al.   Chemical Science

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

(2018) Brice Lagrange et al.   Nature Communications

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

(2018) Sarah Louise Latty et al.   eLife

Dual Role of Toll-like Receptors in Human and Experimental Asthma Models

(2018) Amin Zakeri et al.   Frontiers in Immunology

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection

(2018) Kathrin Krause et al.   Autophagy

Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei

(2018) Michael H. Norris et al.   INFECTION AND IMMUNITY

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation

(2018) Alessio Borio et al.   ChemMedChem

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

The TLR4-TRIF pathway can protect against the development of experimental allergic asthma

(2017) Karim H. Shalaby et al.   IMMUNOLOGY

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

(2017) Xiao Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence

(2017) Peng Li et al.   NATURE

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

(2017) Eric M. Feeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge

(2017) Patrick Younan et al.   mBio

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

(2017) Ryan Finethy et al.   mBio

Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

(2017) Anthony S. Piro et al.   mBio

A Type III Effector NleF from EHEC Inhibits Epithelial Inflammatory Cell Death by Targeting Caspase-4

(2017) Ting Song et al.   Biomed Research International

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Mechanisms of outer membrane vesicle entry into host cells

(2016) Eloise J. O'Donoghue et al.   CELLULAR MICROBIOLOGY

Sepsis—The Final Common Pathway to Death From Multiple Organ Failure in Infection

(2016) Niranjan Kissoon et al.   CRITICAL CARE MEDICINE

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

(2016) Brooke A. Napier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

(2016) M A Pallett et al.   Mucosal Immunology

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

S. Typhimurium strategies to resist killing by cationic antimicrobial peptides

(2015) Susana Matamouros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

Chemical Synthesis ofBurkholderiaLipid A Modified with Glycosyl Phosphodiester-Linked 4-Amino-4-deoxy-β-L-arabinose and Its Immunomodulatory Potential

(2015) Ralph Hollaus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

(2015) Jieling Yang et al.   CURRENT OPINION IN IMMUNOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate ofBurkholderia cenocepacia

(2015) Flaviana Di Lorenzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

(2015) Huan Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LPS modification promotes maintenance of Yersinia pestis in fleas

(2015) Kari L. Aoyagi et al.   MICROBIOLOGY-SGM

Toll-like receptor signalling through macromolecular protein complexes

(2015) Clare E. Bryant et al.   MOLECULAR IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Molecular Regulation of Toll-like Receptors in Asthma and COPD

(2015) Li Zuo et al.   Frontiers in Physiology

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

WildCARDs: Inflammatory caspases directly detect LPS

(2014) Jon Alan Hagar et al.   CELL RESEARCH

Fusion ofLegionella pneumophilaouter membrane vesicles with eukaryotic membrane systems is a mechanism to deliver pathogen factors to host cell membranes

(2014) Jens Jäger et al.   CELLULAR MICROBIOLOGY

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

(2014) Jose Antonio Garate et al.   Innate Immunity

Modulation of Endotoxicity ofShigellaGeneralized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

(2014) Omar Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of the MD-2/TLR4 Interface Required for Signaling by Lipid IVa

(2014) C. Walsh et al.   JOURNAL OF IMMUNOLOGY

Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling

(2014) P. Rallabhandi et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Human Caspase-4 in Endotoxin Sensitivity

(2014) Y. Kajiwara et al.   JOURNAL OF IMMUNOLOGY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformationally Constrained Lipid A Mimetics for Exploration of Structural Basis of TLR4/MD-2 Activation by Lipopolysaccharide

(2013) Daniel Artner et al.   ACS Chemical Biology

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

(2013) Taira Kobayashi et al.   Cell Host & Microbe

Chemistry and Biology of the Potent Endotoxin from aBurkholderia dolosaClinical Isolate from a Cystic Fibrosis Patient

(2013) Flaviana Di Lorenzo et al.   CHEMBIOCHEM

The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity

(2013) Jana K. Eckert et al.   IMMUNITY

Metabolic labeling to characterize the overall composition of Francisella lipid A and LPS grown in broth and in human phagocytes

(2013) Jason H Barker et al.   Innate Immunity

Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses

(2013) Yukari Fujimoto et al.   Molecular BioSystems

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Survey of Innate Immune Responses to Burkholderia pseudomallei in Human Blood Identifies a Central Role for Lipopolysaccharide

(2013) Narisara Chantratita et al.   PLoS One

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating the innate immune response by combinatorial engineering of endotoxin

(2013) Brittany D. Needham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Endotoxins from Within

(2013) J. C. Kagan   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Phosphate Groups of Lipid A Are Essential for Salmonella enterica Serovar Typhimurium Virulence and Affect Innate and Adaptive Immunity

(2012) Qingke Kong et al.   INFECTION AND IMMUNITY

Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses

(2012) Duangjit Kanistanon et al.   INFECTION AND IMMUNITY

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

(2012) Prajwal Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket

(2012) S. L. Kelley et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPS remodeling is an evolved survival strategy for bacteria

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of lipid A profiles fromShigella flexnerivariant X lipopolysaccharide

(2012) Adriana C. Casabuono et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica

(2012) Adeline M. Hajjar et al.   PLoS Pathogens

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

A variety of novel lipid A structures obtained from Francisella tularensis live vaccine strain

(2011) Ashley S Beasley et al.   Innate Immunity

Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions

(2011) J. Meng et al.   JOURNAL OF IMMUNOLOGY

Role of TLR signaling in Francisella tularensis -LPS-induced, antibody-mediated protection against Francisella tularensis challenge

(2011) Leah E. Cole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

3-Deoxy-d-manno-octulosonic Acid (Kdo) Hydrolase Identified inFrancisella tularensis,Helicobacter pylori, andLegionella pneumophila

(2010) Sabina Chalabaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A two-component Kdo hydrolase in the inner membrane of Francisella novicida

(2010) Jinshi Zhao et al.   MOLECULAR MICROBIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis

(2010) Sarah A. Ngugi et al.   VACCINE

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Undecaprenyl Phosphate-β-d-Galactosamine inFrancisella novicidaand Its Function in Lipid A Modification†

(2009) Xiaoyuan Wang et al.   BIOCHEMISTRY

Immunomodulatory Effects of Yersinia pestis Lipopolysaccharides on Human Macrophages

(2009) M. Matsuura et al.   Clinical and Vaccine Immunology

Structural and Biological Diversity of Lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis

(2009) V. Novem et al.   Clinical and Vaccine Immunology

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

A sensitive liquid chromatography/mass spectrometry-based assay for quantitation of amino-containing moieties in lipid A

(2009) Thomas F. Kalhorn et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

(2009) Jennifer M. Bomberger et al.   PLoS Pathogens

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

(2008) C. R. Casella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics

(2008) David Johnson   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

(2008) Anthony De Soyza et al.   Innate Immunity

Glucosamine Found as a Substituent of Both Phosphate Groups in Bordetella Lipid A Backbones: Role of a BvgAS-Activated ArnT Ortholog

(2008) N. Marr et al.   JOURNAL OF BACTERIOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

(2008) Duangjit Kanistanon et al.   PLoS Pathogens